Simple Clinical Risk Score Identifies Patients with Serrated Polyps in Routine Practice

Large, proximal or dysplastic (LPD) serrated polyps (SPs) need accurate endoscopic recognition and removal as these might progress to colorectal Herewith, we examined the risk factors for having >/=1 LPD SP. We validated a simple SP risk score as a potential tool for improving their detection. We reviewed clinical, endoscopic and histologic features of study of patients undergoing elective colonoscopy (derivation cohort). A self-administered questionnaire was obtained. We conducted logistic analyses to identify independent risk factors for having >/=1 LPD SP and incorporated significant variables into a clinical score. We the performance of the SP score in a validation cohort. We examined 2244 in the derivation and 2402 patients in the validation cohort; 6.3% and >/=1 LPD SP, respectively. Independent risk factors for LPD SPs were age years (OR 2.2, 95% CI 1.3 - 3.8, p=0.004), personal history of SPs (OR CI 1.3 - 4.9, p=0.005), current smoking (OR 2.2, 95% CI 1.4 - 3.6, non-daily/no aspirin use (OR 1.8, 95% CI 1.1 - 3.0, p=0.016). In the cohort, a SP score >/=5 points was associated with a 3.0 fold increased LPD SPs, compared to patients with a score <5 points. In the present >50 years, a personal history of SPs, current smoking and non-daily/no use were independent risk factors for having LPD SPs. The SP score might endoscopist in the detection of such lesions.