Simple Clinical Risk Score Identifies Patients with Serrated Polyps in Routine Practice

M.W.E. Bouwens, B. Winkens, E.J.A. Rondagh, A.L.C. Driessen, R.G. Riedl, A.A.M. Masclee, S. Sanduleanu

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Large, proximal or dysplastic (LPD) serrated polyps (SPs) need accurate endoscopic recognition and removal as these might progress to colorectal Herewith, we examined the risk factors for having >/=1 LPD SP. We validated a simple SP risk score as a potential tool for improving their detection. We reviewed clinical, endoscopic and histologic features of study of patients undergoing elective colonoscopy (derivation cohort). A self-administered questionnaire was obtained. We conducted logistic analyses to identify independent risk factors for having >/=1 LPD SP and incorporated significant variables into a clinical score. We the performance of the SP score in a validation cohort. We examined 2244 in the derivation and 2402 patients in the validation cohort; 6.3% and >/=1 LPD SP, respectively. Independent risk factors for LPD SPs were age years (OR 2.2, 95% CI 1.3 - 3.8, p=0.004), personal history of SPs (OR CI 1.3 - 4.9, p=0.005), current smoking (OR 2.2, 95% CI 1.4 - 3.6, non-daily/no aspirin use (OR 1.8, 95% CI 1.1 - 3.0, p=0.016). In the cohort, a SP score >/=5 points was associated with a 3.0 fold increased LPD SPs, compared to patients with a score <5 points. In the present >50 years, a personal history of SPs, current smoking and non-daily/no use were independent risk factors for having LPD SPs. The SP score might endoscopist in the detection of such lesions.
Original languageEnglish
Pages (from-to)855-863
Number of pages9
JournalCancer prevention research
Volume6
Issue number8
DOIs
Publication statusPublished - Aug 2013

Keywords

  • ISLAND METHYLATOR PHENOTYPE
  • COLORECTAL-CANCER
  • HYPERPLASTIC POLYPS
  • AVERAGE-RISK
  • COLON-CANCER
  • LIFE-STYLE
  • ADENOMATOUS POLYPS
  • CIGARETTE-SMOKING
  • BRAF MUTATIONS
  • MISS RATE

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