Similar outcome of tricuspid valve repair and replacement for isolated tricuspid infective endocarditis

Michele Di Mauro*, Giorgia Bonalumi, Ilaria Giambuzzi, Guglielmo Mario Actis Dato, Paolo Centofanti, Alessandro Della Corte, Ester Della Ratta, Diego Cugola, Maurizio Merlo, Francesco Santini, Antonio Salsano, Mauro Rinaldi, Samuel Mancuso, Giangiuseppe Cappabianca, Cesare Beghi, Carlo De Vincentiis, Andrea Biondi, Ugolino Livi, Sandro Sponga, Davide PaciniGiacomo Murana, Roberto Scrofani, Carlo Antona, Giovanni Cagnoni, Francesco Nicolini, Filippo Benassi, Michele De Bonis, Alberto Pozzoli, Marco Pano, Salvatore Nicolardi, Giosuè Falcetta, Andrea Colli, Francesco Musumeci, Riccardo Gherli, Enrico Vizzardi, Loris Salvador, Marco Picichè, Domenico Paparella, Vito Margari, Giovanni Troise, Emmanuel Villa, Yudit Dossena, Carla Lucarelli, Francesco Onorati, Giuseppe Faggian, Giovanni Mariscalco, Daniele Maselli, Fabio Barili, Alessandro Parolari, Roberto Lorusso, Italian Group of Research for Outcome in Cardiac Surgery (GIROC)

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


AIMS: To compare early and late mortality of acute isolated tricuspid valve infective endocarditis (TVIE) treated with valve repair or replacement.

METHODS: Patients who were surgically treated for TVIE from 1983 to 2018 were retrieved from the Italian Registry for Surgical Treatment of Valve and Prosthesis Infective Endocarditis. All the patients were followed up by means of phone interview or calling patient referral physicians or cardiologists. Kaplan-Meier method was used to assess late survival and survival free from TVIE recurrence with log-rank test for univariate comparison. The primary end points were early mortality (30 days after surgery) and long-term survival free from TVIE recurrence.

RESULTS: A total of 4084 patients were included in the registry. Among them, 149 patients were included in the study. Overall, 77 (51.7%) underwent TV repair and 72 (48.3%) TV replacement. Early mortality was 9% (13 patients). Expected early mortality according to EndoSCORE was 12%. The TV repair showed lower mortality and major complication rate (7% and 16%), compared with TV replacement (11% and 25%), but statistical significance was not reached. Median follow-up was 19.1 years (14.3-23.8). Late deaths were 30 and IE recurrences were 5. No difference in cardiac survival free from IE was found between the two groups after 20 years (80 ± 6% Repair Group vs 59 ± 13% Replacement Group, P = 0.3).

CONCLUSIONS: Overall results indicate that once surgically addressed, TVIE has a low recurrence rate and excellent survival, apparently regardless of the type of surgery used to treat it.

Original languageEnglish
Pages (from-to)406-413
Number of pages8
JournalJournal of Cardiovascular Medicine
Issue number6
Publication statusPublished - 1 Jun 2022


  • Cardiac Surgical Procedures/adverse effects
  • Endocarditis, Bacterial/surgery
  • Endocarditis/surgery
  • Humans
  • Treatment Outcome
  • Tricuspid Valve/diagnostic imaging
  • tricuspid valve
  • tricuspid valve replacement
  • tricuspid valve repair
  • endocarditis

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