Significant improvement in postoperative and 1-year mortality after colorectal cancer surgery in recent years

S. H. J. Ketelaers, R. G. Orsini, J. W. A. Burger, G. A. P. Nieuwenhuijzen, H. J. T. Rutten*

*Corresponding author for this work

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Abstract

Background: In earlier studies an association between older patients and higher morbidity and mortality after colorectal surgery is shown, especially in the first postoperative year. We conducted this study to investigate if there is improvement in postoperative morbidity and mortality in senior CRC patients over time.

Materials and methods: All patients, except those with distant metastasis, who received curative CRC surgery between 2006 and 2017 in the Catharina Hospital (Eindhoven, the Netherlands) were selected retrospectively. Differences in mortality and relative survival between different age groups (= 75 years), period of surgery (2006-2012 and 2013-2017) and type of tumor (colon and rectum) were investigated.

Results: In total 2018 patients, of whom 57.4% is male, were selected (n = 1037 colon and n = 981 rectum). 615 (30.5%) patients were >= 75 years old. For electively treated CRC patients aged >= 75 years 30-and 90-day mortality improved from 5.8% to 1.2% (p = 0.004) and 9.1% to 4.6% (p = 0.043) respectively, in favour of the latest time period. Relative one-year survival rates of all electively treated CRC patients were not significantly different between younger and older patients in the latest time period (95.5% vs. 94.3%, p = n.s.)

Conclusions: This study shows significant improvement in postoperative morbidity and mortality over time for both age and treatment groups. Relative survival rates improved especially for older patients and no significant differences were seen between both age groups. Senior CRC patients should not be withheld curative treatment based on age or comorbidities alone. (C) 2019 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

Original languageEnglish
Pages (from-to)2052-2058
Number of pages7
JournalEuropean Journal of Surgical Oncology
Volume45
Issue number11
DOIs
Publication statusPublished - Nov 2019

Keywords

  • Colon cancer
  • Rectal cancer
  • Curative surgery
  • Senior patients
  • Survival
  • Morbidity
  • ELDERLY-PATIENTS
  • RECTAL-CANCER
  • SURGICAL COMPLICATIONS
  • PREHABILITATION
  • OUTCOMES
  • CLASSIFICATION
  • PROGNOSIS
  • IMPACT
  • POPULATION
  • SURVIVAL

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