Significance of uncoupling protein 3 in mitochondrial function upon mid- and long-term dietary high-fat exposure

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Abstract

Uncoupling protein 3 (UCP3) may reduce mitochondrial ROS production, and thereby protect against mitochondrial dysfunction in skeletal muscle. UCP3 has been suggested to specifically fulfill this role under high-fat conditions. Here we show that UCP3 knockout mice indeed have elevated mitochondrial ROS production after short-term (8 weeks) high-fat feeding. After 26 weeks of high-fat feeding, UCP3 knockout mice exhibited reduced mitochondrial function as measured ex vivo in isolated mitochondria. In conclusion, these data suggest that UCP3 may have a role in the protection of mitochondria against lipid-induced mitochondrial dysfunction, but only after long-term exposure to high-fat. 

Original languageEnglish
Pages (from-to)4010-4017
Number of pages8
JournalFebs Letters
Volume585
Issue number24
DOIs
Publication statusPublished - 15 Dec 2011

Keywords

  • UCP3
  • ROS
  • Mitochondria
  • Mild uncoupling
  • Lipotoxicity
  • SKELETAL-MUSCLE MITOCHONDRIA
  • ACID OXIDATION
  • ROS PRODUCTION
  • MICE
  • OVEREXPRESSION
  • METABOLISM
  • LIPOTOXICITY
  • RESPIRATION
  • DYSFUNCTION

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