Short-term outcome in patients treated with cytoreduction and HIPEC compared to conventional colon cancer surgery

Geert A. Simkens, Vic J. Verwaal, Valery E. Lemmens, Harm J. Rutten, Ignace H. de Hingh*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is an extensive procedure with considerable morbidity. Since only few hospitals perform CRS?+?HIPEC, this might lead to confounded outcomes between hospitals when audited. This study aims to compare outcomes between peritoneally metastasized (PM) colon cancer patients treated with CRS?+?HIPEC and patients undergoing conventional colon surgery. Furthermore, the impact of CRS?+?HIPEC on the risk of postoperative complications will be assessed, probably leading to better insight into how to report on postoperative outcomes in this distinct group of patients undergoing extensive colon surgery.All patients with primary colon cancer who underwent segmental colon resection in a tertiary referral hospital between 2011 and 2014 were included in this prospective cohort study. Outcome after surgery was compared between patients who underwent additional CRS?+?HIPEC treatment or conventional surgery.Consequently, 371 patients underwent surgery, of which 43 (12%) underwent CRS?+?HIPEC. These patients were younger and healthier than patients undergoing conventional surgery. Tumor characteristics were less favorable and surgery was more extensive in CRS?+?HIPEC patients. The morbidity rate was also higher in CRS?+?HIPEC patients (70% vs 41%; P?
Original languageEnglish
Article number41
Publication statusPublished - Oct 2016


  • colonic neoplasms
  • cytoreduction surgical procedures
  • hyperthermic intraperitoneal chemotherapy
  • morbidity
  • outcome assessment
  • peritoneal neoplasms
  • postoperative complications

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