Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

M.J. Hanssen; J. Hoeks; B. Brans; A.A. van der Lans; G. Schaart; J.J. van den Driessche; J.A. Jorgensen; M.V. Boekschoten; M.K. Hesselink; B. Havekes; S. Kersten; F.M. Mottaghy; W.D. van Marken Lichtenbelt; P. Schrauwen

doi:10.1038/nm.3891

Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

M.J. Hanssen
, J. Hoeks
, B. Brans
, A.A. van der Lans
, G. Schaart
, J.J. van den Driessche
, J.A. Jorgensen
, M.V. Boekschoten
, M.K. Hesselink
, B. Havekes
, S. Kersten
, F.M. Mottaghy
, W.D. van Marken Lichtenbelt
, P. Schrauwen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14-15 degrees C) increased peripheral insulin sensitivity by approximately 43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake.

Original language	English
Pages (from-to)	863-865
Number of pages	3
Journal	Nature Medicine
Volume	21
Issue number	8
DOIs	https://doi.org/10.1038/nm.3891
Publication status	Published - Aug 2015

Keywords

BROWN ADIPOSE-TISSUE
MITOCHONDRIAL-FUNCTION
METABOLIC FLEXIBILITY
ENERGY-EXPENDITURE
GLUCOSE-UPTAKE
THERMOGENESIS
FAT
HUMANS
MUSCLE
HOMEOSTASIS

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Hanssen, M. J., Hoeks, J., Brans, B., van der Lans, A. A., Schaart, G., van den Driessche, J. J., Jorgensen, J. A., Boekschoten, M. V., Hesselink, M. K., Havekes, B., Kersten, S., Mottaghy, F. M., van Marken Lichtenbelt, W. D., & Schrauwen, P. (2015). Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus. Nature Medicine, 21(8), 863-865. https://doi.org/10.1038/nm.3891

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title = "Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus",

abstract = "Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14-15 degrees C) increased peripheral insulin sensitivity by approximately 43\% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake.",

keywords = "BROWN ADIPOSE-TISSUE, MITOCHONDRIAL-FUNCTION, METABOLIC FLEXIBILITY, ENERGY-EXPENDITURE, GLUCOSE-UPTAKE, THERMOGENESIS, FAT, HUMANS, MUSCLE, HOMEOSTASIS",

author = "M.J. Hanssen and J. Hoeks and B. Brans and \{van der Lans\}, A.A. and G. Schaart and \{van den Driessche\}, J.J. and J.A. Jorgensen and M.V. Boekschoten and M.K. Hesselink and B. Havekes and S. Kersten and F.M. Mottaghy and \{van Marken Lichtenbelt\}, W.D. and P. Schrauwen",

year = "2015",

month = aug,

doi = "10.1038/nm.3891",

language = "English",

volume = "21",

pages = "863--865",

journal = "Nature Medicine",

issn = "1078-8956",

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Hanssen, MJ, Hoeks, J, Brans, B, van der Lans, AA, Schaart, G, van den Driessche, JJ, Jorgensen, JA, Boekschoten, MV, Hesselink, MK, Havekes, B, Kersten, S, Mottaghy, FM , van Marken Lichtenbelt, WD & Schrauwen, P 2015, 'Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus', Nature Medicine, vol. 21, no. 8, pp. 863-865. https://doi.org/10.1038/nm.3891

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T1 - Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

AU - Hanssen, M.J.

AU - Hoeks, J.

AU - Brans, B.

AU - van der Lans, A.A.

AU - Schaart, G.

AU - van den Driessche, J.J.

AU - Jorgensen, J.A.

AU - Boekschoten, M.V.

AU - Hesselink, M.K.

AU - Havekes, B.

AU - Kersten, S.

AU - Mottaghy, F.M.

AU - van Marken Lichtenbelt, W.D.

AU - Schrauwen, P.

PY - 2015/8

Y1 - 2015/8

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AB - Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14-15 degrees C) increased peripheral insulin sensitivity by approximately 43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake.

KW - BROWN ADIPOSE-TISSUE

KW - MITOCHONDRIAL-FUNCTION

KW - METABOLIC FLEXIBILITY

KW - ENERGY-EXPENDITURE

KW - GLUCOSE-UPTAKE

KW - THERMOGENESIS

KW - FAT

KW - HUMANS

KW - MUSCLE

KW - HOMEOSTASIS

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DO - 10.1038/nm.3891

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SN - 1078-8956

VL - 21

SP - 863

EP - 865

JO - Nature Medicine

JF - Nature Medicine

IS - 8

ER -

Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

Abstract

Keywords

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