Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

M.J. Hanssen, J. Hoeks, B. Brans, A.A. van der Lans, G. Schaart, J.J. van den Driessche, J.A. Jorgensen, M.V. Boekschoten, M.K. Hesselink, B. Havekes, S. Kersten, F.M. Mottaghy, W.D. van Marken Lichtenbelt, P. Schrauwen

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14-15 degrees C) increased peripheral insulin sensitivity by approximately 43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake.
Original languageEnglish
Pages (from-to)863-865
Number of pages3
JournalNature Medicine
Volume21
Issue number8
DOIs
Publication statusPublished - Aug 2015

Keywords

  • BROWN ADIPOSE-TISSUE
  • MITOCHONDRIAL-FUNCTION
  • METABOLIC FLEXIBILITY
  • ENERGY-EXPENDITURE
  • GLUCOSE-UPTAKE
  • THERMOGENESIS
  • FAT
  • HUMANS
  • MUSCLE
  • HOMEOSTASIS

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