Abstract
Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14-15 degrees C) increased peripheral insulin sensitivity by approximately 43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake.
Original language | English |
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Pages (from-to) | 863-865 |
Number of pages | 3 |
Journal | Nature Medicine |
Volume | 21 |
Issue number | 8 |
DOIs | |
Publication status | Published - Aug 2015 |
Keywords
- BROWN ADIPOSE-TISSUE
- MITOCHONDRIAL-FUNCTION
- METABOLIC FLEXIBILITY
- ENERGY-EXPENDITURE
- GLUCOSE-UPTAKE
- THERMOGENESIS
- FAT
- HUMANS
- MUSCLE
- HOMEOSTASIS