Short-chain fatty acids: the link between gut microbiota and metabolic health

Research output: ThesisDoctoral ThesisInternal

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Global obesity rates are increasing more and more. Short-chain fatty acids, the end products of fermentation of indigestible carbohydrates by intestinal bacteria, can influence metabolism and therefore play a role in the development of obesity and diabetes. The studies described in this dissertation show that the administration of short-chain fatty acids to the colon of overweight men increases energy expenditure and fat metabolism and reduces appetite and inflammation. The increase in the number of short-chain fatty acids in the colon by food intake can vitally contribute to the treatment or prevention of obesity and diabetes.
Original languageEnglish
Awarding Institution
  • Maastricht University
  • Blaak, Ellen, Supervisor
  • Jocken, Johan, Co-Supervisor
  • Lenaerts, Kaatje, Co-Supervisor
Award date23 Sept 2016
Place of PublicationMaastricht
Publication statusPublished - 2016


  • obesity
  • gut microbiota
  • dietary fibers
  • short-chain fatty acids
  • human metabolism

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