Short- and Long-term exercise induced alterations in haemostasis: a review of the literature

Jelle J. Posthuma*, Paola E. J. van der Meijden, Hugo ten Cate, Henri M. H. Spronk

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Although regular exercise is beneficial for health, exercise-related thrombotic events, such as venous thromboembolism and myocardial infarctions, are occasionally observed. These events are characterized by a prothrombotic condition in which interactions between coagulation factors, the vessel wall and the fibrinolytic system play an important role. Apparently, various durations and intensities of exercise have different effects on haemostasis and especially high intensity exercise tends to increase the risk of thrombotic events. However, the mechanisms behind this have not been entirely established. In this review we provide an overview of the various effects of the different intensities and durations of exercise on haemostasis. Overall, the haemostatic profile is mainly affected by the intensity of exercise; and is more pronounced after high (>80%) compared to low intensity (
Original languageEnglish
Pages (from-to)171-178
JournalBlood Reviews
Issue number3
Publication statusPublished - May 2015


  • Exercise
  • Haemostasis
  • Platelets
  • Cardiovascular diseases
  • Blood coagulation

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