TY - JOUR
T1 - Shared genetic influences between dimensional ASD and ADHD symptoms during child and adolescent development
AU - Stergiakouli, Evie
AU - Smith, George Davey
AU - Martin, Joanna
AU - Skuse, David H.
AU - Viechtbauer, Wolfgang
AU - Ring, Susan M.
AU - Ronald, Angelica
AU - Evans, David E.
AU - Fisher, Simon E.
AU - Thapar, Anita
AU - St Pourcain, Beate
PY - 2017/4/4
Y1 - 2017/4/4
N2 - Background: Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) symptoms and autism spectrum disorder (ASD) symptoms have been reported. Cross-trait genetic relationships are, however, subject to dynamic changes during development. We investigated the continuity of genetic overlap between ASD and ADHD symptoms in a general population sample during childhood and adolescence. We also studied uni- and cross-dimensional trait-disorder links with respect to genetic ADHD and ASD risk.Methods: Social-communication difficulties (N = 5551, Social and Communication Disorders Checklist, SCDC) and combined hyperactive-impulsive/inattentive ADHD symptoms (N = 5678, Strengths and Difficulties Questionnaire, SDQ- ADHD) were repeatedly measured in a UK birth cohort (ALSPAC, age 7 to 17 years). Genome- wide summary statistics on clinical ASD (5305 cases; 5305 pseudo- controls) and ADHD (4163 cases; 12,040 controls/pseudo- controls) were available from the Psychiatric Genomics Consortium. Genetic trait variances and genetic overlap between phenotypes were estimated using genome-wide data.Results: In the general population, genetic influences for SCDC and SDQ-ADHD scores were shared throughout development. Genetic correlations across traits reached a similar strength and magnitude (cross- trait r(g)Conclusions: In the general population, genetic aetiologies between social-communication difficulties and ADHD symptoms are shared throughout child and adolescent development and may implicate similar biological pathways that co-vary during development. Within both the ASD and the ADHD dimension, population-based traits are also linked to clinical disorder, although much larger clinical discovery samples are required to reliably detect cross-dimensional trait-disorder relationships.
AB - Background: Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) symptoms and autism spectrum disorder (ASD) symptoms have been reported. Cross-trait genetic relationships are, however, subject to dynamic changes during development. We investigated the continuity of genetic overlap between ASD and ADHD symptoms in a general population sample during childhood and adolescence. We also studied uni- and cross-dimensional trait-disorder links with respect to genetic ADHD and ASD risk.Methods: Social-communication difficulties (N = 5551, Social and Communication Disorders Checklist, SCDC) and combined hyperactive-impulsive/inattentive ADHD symptoms (N = 5678, Strengths and Difficulties Questionnaire, SDQ- ADHD) were repeatedly measured in a UK birth cohort (ALSPAC, age 7 to 17 years). Genome- wide summary statistics on clinical ASD (5305 cases; 5305 pseudo- controls) and ADHD (4163 cases; 12,040 controls/pseudo- controls) were available from the Psychiatric Genomics Consortium. Genetic trait variances and genetic overlap between phenotypes were estimated using genome-wide data.Results: In the general population, genetic influences for SCDC and SDQ-ADHD scores were shared throughout development. Genetic correlations across traits reached a similar strength and magnitude (cross- trait r(g)Conclusions: In the general population, genetic aetiologies between social-communication difficulties and ADHD symptoms are shared throughout child and adolescent development and may implicate similar biological pathways that co-vary during development. Within both the ASD and the ADHD dimension, population-based traits are also linked to clinical disorder, although much larger clinical discovery samples are required to reliably detect cross-dimensional trait-disorder relationships.
KW - Social communication
KW - ADHD symptoms
KW - Clinical ADHD
KW - ALSPAC
KW - Genetic overlap
KW - ATTENTION-DEFICIT/HYPERACTIVITY DISORDER
KW - DEFICIT HYPERACTIVITY DISORDER
KW - AUTISM SPECTRUM DISORDER
KW - METABOTROPIC GLUTAMATE-RECEPTOR
KW - GENOME-WIDE ASSOCIATION
KW - DIFFICULTIES QUESTIONNAIRE
KW - GENERAL-POPULATION
KW - SOCIAL-COMMUNICATION
KW - TWIN SAMPLE
KW - TRAITS
UR - https://springernature.figshare.com/articles/dataset/Additional_file_2_Table_S9_of_Shared_genetic_influences_between_dimensional_ASD_and_ADHD_symptoms_during_child_and_adolescent_development/4814401/1
U2 - 10.1186/s13229-017-0131-2
DO - 10.1186/s13229-017-0131-2
M3 - Article
C2 - 28392908
SN - 2040-2392
VL - 8
JO - Molecular Autism
JF - Molecular Autism
IS - 1
M1 - 18
ER -