Shared genetic background between children and adults with attention deficit/hyperactivity disorder

Paula Rovira, Ditte Demontis, Cristina Sanchez-Mora, Tetyana Zayats, Marieke Klein, Nina Roth Mota, Heike Weber, Iris Garcia-Martinez, Mireia Pagerols, Laura Vilar-Ribo, Lorena Arribas, Vanesa Richarte, Montserrat Corrales, Christian Fadeuilhe, Rosa Bosch, Gemma Espanol Martin, Peter Almos, Alysa E. Doyle, Eugenio Horacio Grevet, Oliver GrimmAnne Halmoy, Martine Hoogman, Mara Hutz, Christian P. Jacob, Sarah Kittel-Schneider, Per M. Knappskog, Astri J. Lundervold, Olga Rivero, Diego Luiz Rovaris, Angelica Salatino-Oliveira, Bruna Santos da Silva, Evgeniy Svirin, Emma Sprooten, Tatyana Strekalova, Alejandro Arias-Vasquez, Edmund J. S. Sonuga-Barke, Philip Asherson, Claiton Henrique Dotto Bau, Jan K. Buitelaar, Bru Cormand, Stephen V. Faraone, Jan Haavik, Stefan E. Johansson, Jonna Kuntsi, Henrik Larsson, Klaus-Peter Lesch, Andreas Reif, Luis Augusto Rohde, Miquel Casas, Anders D. Borglum, Barbara Franke, Josep Antoni Ramos-Quiroga, Maria Soler Artigas*, Marta Ribases*, ADHD Working Group of the Psychiatric Genomics Consortium, 23andMe Research team

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

37 Citations (Web of Science)

Abstract

Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by age-inappropriate symptoms of inattention, impulsivity, and hyperactivity that persist into adulthood in the majority of the diagnosed children. Despite several risk factors during childhood predicting the persistence of ADHD symptoms into adulthood, the genetic architecture underlying the trajectory of ADHD over time is still unclear. We set out to study the contribution of common genetic variants to the risk for ADHD across the lifespan by conducting meta-analyses of genome-wide association studies on persistent ADHD in adults and ADHD in childhood separately and jointly, and by comparing the genetic background between them in a total sample of 17,149 cases and 32,411 controls. Our results show nine new independent loci and support a shared contribution of common genetic variants to ADHD in children and adults. No subgroup heterogeneity was observed among children, while this group consists of future remitting and persistent individuals. We report similar patterns of genetic correlation of ADHD with other ADHD-related datasets and different traits and disorders among adults, children, and when combining both groups. These findings confirm that persistent ADHD in adults is a neurodevelopmental disorder and extend the existing hypothesis of a shared genetic architecture underlying ADHD and different traits to a lifespan perspective.

Original languageEnglish
Pages (from-to)1617-1626
Number of pages10
JournalNeuropsychopharmacology
Volume45
Issue number10
DOIs
Publication statusPublished - Sep 2020

Keywords

  • GENOME-WIDE ASSOCIATION
  • DEFICIT HYPERACTIVITY DISORDER
  • CA2+-DEPENDENT ACTIVATOR PROTEIN
  • LD SCORE REGRESSION
  • SECRETION 2
  • ADHD
  • HERITABILITY
  • CHILDHOOD
  • SYMPTOMS
  • METAANALYSIS

Cite this