TY - JOUR
T1 - Sex-Specific Relationship Between Parathyroid Hormone and Platelet Indices in Phenotypes of Heart Failure - Results From the MyoVasc Study
AU - Dahlen, Bianca
AU - Mueller, Felix
AU - Troebs, Sven-Oliver
AU - Heidorn, Marc William
AU - Schulz, Andreas
AU - Arnold, Natalie
AU - Hermanns, M. Iris
AU - Schwuchow-Thonke, Soeren
AU - Prochaska, Juergen H.
AU - Gori, Tommaso
AU - ten Cate, Hugo
AU - Lackner, Karl J.
AU - Muenzel, Thomas
AU - Wild, Philipp S.
AU - Panova-Noeva, Marina
PY - 2021/6/16
Y1 - 2021/6/16
N2 - Background: Heart failure (HF) is a multifactorial syndrome with pathophysiological complexities still not fully understood. Higher mean platelet volume (MPV), a potential marker of platelet activation, and high concentrations of parathyroid hormone (PTH) have been implicated in the pathogenesis of HF.Aim: This study aims to investigate sex-specifically the association between PTH concentrations and platelet indices in phenotypes of HF.Methods and Results: PTH and platelet indices (MPV and platelet count) were available in 1,896 participants from the MyoVasc study in Mainz, Germany. Multivariable linear regression models, adjusted for age, sex, season, vitamin D status, cardiovascular risk factors, comorbidities, estimated glomerular filtration rate, and medication, were used to assess the associations between platelet indices and PTH. The results showed distinct sex-specific associations between PTH and platelet indices. A positive association between PTH and MPV was found in females with symptomatic HF with reduced ejection fraction (HFrEF) only [beta = 0.60 (0.19; 1.00)]. Platelet count was inversely associated with PTH in male HFrEF individuals [beta = -7.6 (-15; -0.30)] and in both males and females with HF with preserved ejection fraction (HFpEF).Conclusion: This study reports differential, sex-specific relationships between PTH and platelet indices in HF individuals independent of vitamin D status and clinical profile. Particularly in phenotypes of symptomatic HF, distinct associations were observed, suggesting a sex-specific mechanism involved in the interaction between PTH and platelets.
AB - Background: Heart failure (HF) is a multifactorial syndrome with pathophysiological complexities still not fully understood. Higher mean platelet volume (MPV), a potential marker of platelet activation, and high concentrations of parathyroid hormone (PTH) have been implicated in the pathogenesis of HF.Aim: This study aims to investigate sex-specifically the association between PTH concentrations and platelet indices in phenotypes of HF.Methods and Results: PTH and platelet indices (MPV and platelet count) were available in 1,896 participants from the MyoVasc study in Mainz, Germany. Multivariable linear regression models, adjusted for age, sex, season, vitamin D status, cardiovascular risk factors, comorbidities, estimated glomerular filtration rate, and medication, were used to assess the associations between platelet indices and PTH. The results showed distinct sex-specific associations between PTH and platelet indices. A positive association between PTH and MPV was found in females with symptomatic HF with reduced ejection fraction (HFrEF) only [beta = 0.60 (0.19; 1.00)]. Platelet count was inversely associated with PTH in male HFrEF individuals [beta = -7.6 (-15; -0.30)] and in both males and females with HF with preserved ejection fraction (HFpEF).Conclusion: This study reports differential, sex-specific relationships between PTH and platelet indices in HF individuals independent of vitamin D status and clinical profile. Particularly in phenotypes of symptomatic HF, distinct associations were observed, suggesting a sex-specific mechanism involved in the interaction between PTH and platelets.
KW - heart failure
KW - MPV
KW - platelet count
KW - parathyroid hormone
KW - heart failure with preserved ejection fraction
KW - heart failure with reduced ejection fraction
KW - VITAMIN-D
KW - PATHOPHYSIOLOGY
KW - DYSFUNCTION
KW - MANAGEMENT
KW - MORTALITY
KW - BIOMARKER
KW - DISEASE
KW - RISK
U2 - 10.3389/fcvm.2021.682521
DO - 10.3389/fcvm.2021.682521
M3 - Article
C2 - 34222377
SN - 2297-055X
VL - 8
JO - Frontiers in Cardiovascular Medicine
JF - Frontiers in Cardiovascular Medicine
M1 - 682521
ER -