Sex-Specific Relationship Between Parathyroid Hormone and Platelet Indices in Phenotypes of Heart Failure - Results From the MyoVasc Study

Bianca Dahlen, Felix Mueller, Sven-Oliver Troebs, Marc William Heidorn, Andreas Schulz, Natalie Arnold, M. Iris Hermanns, Soeren Schwuchow-Thonke, Juergen H. Prochaska, Tommaso Gori, Hugo ten Cate, Karl J. Lackner, Thomas Muenzel, Philipp S. Wild, Marina Panova-Noeva*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: Heart failure (HF) is a multifactorial syndrome with pathophysiological complexities still not fully understood. Higher mean platelet volume (MPV), a potential marker of platelet activation, and high concentrations of parathyroid hormone (PTH) have been implicated in the pathogenesis of HF.

Aim: This study aims to investigate sex-specifically the association between PTH concentrations and platelet indices in phenotypes of HF.

Methods and Results: PTH and platelet indices (MPV and platelet count) were available in 1,896 participants from the MyoVasc study in Mainz, Germany. Multivariable linear regression models, adjusted for age, sex, season, vitamin D status, cardiovascular risk factors, comorbidities, estimated glomerular filtration rate, and medication, were used to assess the associations between platelet indices and PTH. The results showed distinct sex-specific associations between PTH and platelet indices. A positive association between PTH and MPV was found in females with symptomatic HF with reduced ejection fraction (HFrEF) only [beta = 0.60 (0.19; 1.00)]. Platelet count was inversely associated with PTH in male HFrEF individuals [beta = -7.6 (-15; -0.30)] and in both males and females with HF with preserved ejection fraction (HFpEF).

Conclusion: This study reports differential, sex-specific relationships between PTH and platelet indices in HF individuals independent of vitamin D status and clinical profile. Particularly in phenotypes of symptomatic HF, distinct associations were observed, suggesting a sex-specific mechanism involved in the interaction between PTH and platelets.

Original languageEnglish
Article number682521
Number of pages10
JournalFrontiers in cardiovascular medicine
Volume8
DOIs
Publication statusPublished - 16 Jun 2021

Keywords

  • heart failure
  • MPV
  • platelet count
  • parathyroid hormone
  • heart failure with preserved ejection fraction
  • heart failure with reduced ejection fraction
  • VITAMIN-D
  • PATHOPHYSIOLOGY
  • DYSFUNCTION
  • MANAGEMENT
  • MORTALITY
  • BIOMARKER
  • DISEASE
  • RISK

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