Sex hormone-binding globulin and thrombin generation in women using hormonal contraception

Justine Hugon-Rodin; Martine Alhenc-Gelas; H. Coenraad Hemker; Sylvie Brailly-Tabard; Anne Guiochon-Mantel; Genevieve Plu-Bureau; Pierre-Yves Scarabin

doi:10.1080/1354750X.2016.1204010

Sex hormone-binding globulin and thrombin generation in women using hormonal contraception

Justine Hugon-Rodin^*
, Martine Alhenc-Gelas
, H. Coenraad Hemker
, Sylvie Brailly-Tabard
, Anne Guiochon-Mantel
, Genevieve Plu-Bureau
, Pierre-Yves Scarabin

^*Corresponding author for this work

Biochemie

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objectives: We investigated the impact of serum sex hormone-binding globulin (SHBG) on thrombin generation (TG) in women according to hormonal contraception.

Patients and methods: A cross-sectional study of SHBG and TG measured via calibrated automated thrombography was conducted in 150 healthy women, including 75 users of combined oral contraceptives (COC), 22 users of progestin-only contraceptives (POC) and 53 nonusers.

Results: COC but not POC-users had significantly higher SHBG levels compared with nonusers. In hormonal contraceptive users, SHBG was positively associated with both activated protein C (APC) resistance and baseline TG, and protein S and prothrombin were important mediators.

Conclusion: These data provide further evidence that SHBG may be used as a biomarker in assessing prothrombotic profile of hormonal contraception.

Original language	English
Pages (from-to)	81-85
Number of pages	5
Journal	Biomarkers
Volume	22
Issue number	1
DOIs	https://doi.org/10.1080/1354750X.2016.1204010
Publication status	Published - 2017

Keywords

Biomarkers
hemostasis
prothrombotic
PROGESTIN-ONLY CONTRACEPTION
COMBINED ORAL-CONTRACEPTIVES
PROTEIN-C RESISTANCE
VENOUS THROMBOEMBOLISM
SURROGATE MARKER
RISK
PLASMA
METAANALYSIS
COAGULATION
THERAPY

Access to Document

10.1080/1354750X.2016.1204010

Cite this

@article{4cc3a9f64e6543e4b35c3ad47787f958,

title = "Sex hormone-binding globulin and thrombin generation in women using hormonal contraception",

abstract = "Objectives: We investigated the impact of serum sex hormone-binding globulin (SHBG) on thrombin generation (TG) in women according to hormonal contraception.Patients and methods: A cross-sectional study of SHBG and TG measured via calibrated automated thrombography was conducted in 150 healthy women, including 75 users of combined oral contraceptives (COC), 22 users of progestin-only contraceptives (POC) and 53 nonusers.Results: COC but not POC-users had significantly higher SHBG levels compared with nonusers. In hormonal contraceptive users, SHBG was positively associated with both activated protein C (APC) resistance and baseline TG, and protein S and prothrombin were important mediators.Conclusion: These data provide further evidence that SHBG may be used as a biomarker in assessing prothrombotic profile of hormonal contraception.",

keywords = "Biomarkers, hemostasis, prothrombotic, PROGESTIN-ONLY CONTRACEPTION, COMBINED ORAL-CONTRACEPTIVES, PROTEIN-C RESISTANCE, VENOUS THROMBOEMBOLISM, SURROGATE MARKER, RISK, PLASMA, METAANALYSIS, COAGULATION, THERAPY",

author = "Justine Hugon-Rodin and Martine Alhenc-Gelas and Hemker, \{H. Coenraad\} and Sylvie Brailly-Tabard and Anne Guiochon-Mantel and Genevieve Plu-Bureau and Pierre-Yves Scarabin",

year = "2017",

doi = "10.1080/1354750X.2016.1204010",

language = "English",

volume = "22",

pages = "81--85",

journal = "Biomarkers",

issn = "1354-750X",

publisher = "Routledge/Taylor \& Francis Group",

number = "1",

}

TY - JOUR

T1 - Sex hormone-binding globulin and thrombin generation in women using hormonal contraception

AU - Hugon-Rodin, Justine

AU - Alhenc-Gelas, Martine

AU - Hemker, H. Coenraad

AU - Brailly-Tabard, Sylvie

AU - Guiochon-Mantel, Anne

AU - Plu-Bureau, Genevieve

AU - Scarabin, Pierre-Yves

PY - 2017

Y1 - 2017

N2 - Objectives: We investigated the impact of serum sex hormone-binding globulin (SHBG) on thrombin generation (TG) in women according to hormonal contraception.Patients and methods: A cross-sectional study of SHBG and TG measured via calibrated automated thrombography was conducted in 150 healthy women, including 75 users of combined oral contraceptives (COC), 22 users of progestin-only contraceptives (POC) and 53 nonusers.Results: COC but not POC-users had significantly higher SHBG levels compared with nonusers. In hormonal contraceptive users, SHBG was positively associated with both activated protein C (APC) resistance and baseline TG, and protein S and prothrombin were important mediators.Conclusion: These data provide further evidence that SHBG may be used as a biomarker in assessing prothrombotic profile of hormonal contraception.

AB - Objectives: We investigated the impact of serum sex hormone-binding globulin (SHBG) on thrombin generation (TG) in women according to hormonal contraception.Patients and methods: A cross-sectional study of SHBG and TG measured via calibrated automated thrombography was conducted in 150 healthy women, including 75 users of combined oral contraceptives (COC), 22 users of progestin-only contraceptives (POC) and 53 nonusers.Results: COC but not POC-users had significantly higher SHBG levels compared with nonusers. In hormonal contraceptive users, SHBG was positively associated with both activated protein C (APC) resistance and baseline TG, and protein S and prothrombin were important mediators.Conclusion: These data provide further evidence that SHBG may be used as a biomarker in assessing prothrombotic profile of hormonal contraception.

KW - Biomarkers

KW - hemostasis

KW - prothrombotic

KW - PROGESTIN-ONLY CONTRACEPTION

KW - COMBINED ORAL-CONTRACEPTIVES

KW - PROTEIN-C RESISTANCE

KW - VENOUS THROMBOEMBOLISM

KW - SURROGATE MARKER

KW - RISK

KW - PLASMA

KW - METAANALYSIS

KW - COAGULATION

KW - THERAPY

U2 - 10.1080/1354750X.2016.1204010

DO - 10.1080/1354750X.2016.1204010

M3 - Article

SN - 1354-750X

VL - 22

SP - 81

EP - 85

JO - Biomarkers

JF - Biomarkers

IS - 1

ER -

Sex hormone-binding globulin and thrombin generation in women using hormonal contraception

Abstract

Keywords

Access to Document

Fingerprint

Cite this