Sex differences in the longitudinal relationship of low-grade inflammation and echocardiographic measures in the Hoorn and FLEMENGHO Study

Sharon Remmelzwaal*, Joline W. J. Beulens, Petra J. M. Elders, Coen D. A. Stehouwer, Zhenyu Zhang, M. Louis Handoko, Yolande Appelman, Vanessa van Empel, Stephane R. B. Heymans, Lutgarde Thijs, Jan A. Staessen, A. Johanne van Ballegooijen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background This study aimed to determine the within-person and between-persons associations of low-grade inflammation (LGI) and endothelial dysfunction (ED) with echocardiographic measures related to diastolic dysfunction (DD) in two general populations and whether these associations differed by sex.

Methods Biomarkers and echocardiographic measures were measured at both baseline and follow-up in the Hoorn Study (n = 383) and FLEMENGHO (n = 491). Individual biomarker levels were combined into either a Z-score of LGI (CRP, SAA, IL-6, IL-8, TNF-alpha and sICAM-1) or ED (sICAM-1, sVCAM-1, sE-selectin and sTM). Mixed models were used to determine within-person and between-persons associations of biomarker Z-scores with left ventricular ejection fraction (LVEF), left ventricular mass index (LVMI) and left atrial volume index (LAVI). These associations were adjusted for a-priori selected confounders.

Results Overall Z-scores for LGI or ED were not associated with echocardiographic measures. Effect modification by sex was apparent for ED with LVEF in both cohorts (P-for interaction = 0.08 and 0.06), but stratified results were not consistent. Effect modification by sex was apparent for TNF-alpha in the Hoorn Study and E-selectin in FLEMENGHO with LVEF (P-for interaction

Conclusion Our study did not show consistent associations of LGI and ED with echocardiographic measures. Some evidence of effect modification by sex was present for ED and specific biomarkers.

Original languageEnglish
Article number0251148
Number of pages14
JournalPLOS ONE
Volume16
Issue number5
DOIs
Publication statusPublished - 4 May 2021

Keywords

  • VENTRICULAR EJECTION FRACTION
  • CHRONIC HEART-FAILURE
  • DIASTOLIC DYSFUNCTION
  • REACTIVE PROTEIN
  • EUROPEAN-SOCIETY
  • TASK-FORCE
  • PREVALENCE
  • DIAGNOSIS
  • ASSOCIATION
  • ADULTS

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