TY - JOUR
T1 - Sex differences in body mass index and waist circumference trajectories and dementia risk
T2 - the HUNT4 70+study
AU - Zotcheva, Ekaterina
AU - Strand, Bjorn Heine
AU - Skirbekk, Vegard
AU - Deckers, Kay
AU - Krokstad, Steinar
AU - Livingston, Gill
AU - Singh-Manoux, Archana
AU - Selbaek, Geir
PY - 2025/4/1
Y1 - 2025/4/1
N2 - We examined associations between body mass index (BMI), waist circumference (WC), and dementia risk, and differences in BMI and WC trajectories before dementia diagnosis. We included 9,739 participants (54% women) aged 70+ from the Tr & oslash;ndelag Health Study (HUNT4 70+). BMI was measured four times (1984-2019) and WC three times (1995-2019). Dementia diagnoses were clinically assessed at HUNT4 70+ . Women and men with dementia had higher midlife BMI and WC than those without dementia. These differences diminished closer to diagnosis, especially in women. Midlife obesity in both sexes and midlife overweight, high WC, and overweight/obesity with high WC in men were linked to higher dementia risk. Lower dementia risk was observed with late-life overweight for both sexes, late-life high WC in women, late-life overweight/obesity with normal WC in men or high WC in women. Adiposity measures and their changes influence dementia risk differently in women and men.
AB - We examined associations between body mass index (BMI), waist circumference (WC), and dementia risk, and differences in BMI and WC trajectories before dementia diagnosis. We included 9,739 participants (54% women) aged 70+ from the Tr & oslash;ndelag Health Study (HUNT4 70+). BMI was measured four times (1984-2019) and WC three times (1995-2019). Dementia diagnoses were clinically assessed at HUNT4 70+ . Women and men with dementia had higher midlife BMI and WC than those without dementia. These differences diminished closer to diagnosis, especially in women. Midlife obesity in both sexes and midlife overweight, high WC, and overweight/obesity with high WC in men were linked to higher dementia risk. Lower dementia risk was observed with late-life overweight for both sexes, late-life high WC in women, late-life overweight/obesity with normal WC in men or high WC in women. Adiposity measures and their changes influence dementia risk differently in women and men.
KW - Anthropometric measures
KW - Cognitive impairment
KW - Life-course perspective
KW - Adiposity
KW - Population-based study
KW - COGNITIVE IMPAIRMENT
KW - OBESITY
KW - ASSOCIATION
KW - METAANALYSIS
KW - GENDER
KW - COHORT
KW - FAT
U2 - 10.1007/s11357-025-01660-3
DO - 10.1007/s11357-025-01660-3
M3 - Article
SN - 2509-2715
JO - Geroscience
JF - Geroscience
ER -