Severity of pulmonary involvement and F-18-FDG PET activity in sarcoidosis

Remy L. M. Mostard; Johny A. Verschakelen; Marinus J. P. G. van Kroonenburgh; Patty J. Nelemans; Petal A. H. M. Wijnen; Stefan Voo; Marjolein Drent

doi:10.1016/j.rmed.2012.11.011

Severity of pulmonary involvement and F-18-FDG PET activity in sarcoidosis

Remy L. M. Mostard, Johny A. Verschakelen, Marinus J. P. G. van Kroonenburgh, Patty J. Nelemans, Petal A. H. M. Wijnen, Stefan Voo, Marjolein Drent^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Assessing inflammatory activity is useful in the management of persistent symptomatic sarcoidosis patients. F-18-FDG PET (PET) has been shown to be a sensitive technique to assess inflammatory activity in sarcoidosis. The aim of this study was to evaluate whether the severity of pulmonary involvement is associated with PET activity in persistent symptomatic sarcoidosis patients. Methods: Over a 5-year period, relevant clinical data including laboratory and lung function test results were gathered from the medical records of 95 sarcoidosis patients with persistent disabling symptoms who underwent both a PET and HRCT. HRCT scans were classified using a semiquantitative scoring system and PET findings as positive or negative, respectively. Results: PET was positive in 77/95 patients, of whom 56 demonstrated pulmonary PET-positivity. HRCT scores were high (7.1 +/- 3.6) in patients with positive pulmonary PET findings (n = 56) compared to patients with negative pulmonary PET findings (n = 39; 3.0 +/- 2.9; p

Original language	English
Pages (from-to)	439-447
Journal	Respiratory Medicine
Volume	107
Issue number	3
DOIs	https://doi.org/10.1016/j.rmed.2012.11.011
Publication status	Published - Mar 2013

Keywords

Sarcoidosis
HRCT
PET
FDG
Lung function
Inflammatory activity

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10.1016/j.rmed.2012.11.011Licence: Free access - publisher

Cite this

@article{977b0dd0952f4e8099768a599fe45ff2,

title = "Severity of pulmonary involvement and F-18-FDG PET activity in sarcoidosis",

abstract = "Background: Assessing inflammatory activity is useful in the management of persistent symptomatic sarcoidosis patients. F-18-FDG PET (PET) has been shown to be a sensitive technique to assess inflammatory activity in sarcoidosis. The aim of this study was to evaluate whether the severity of pulmonary involvement is associated with PET activity in persistent symptomatic sarcoidosis patients. Methods: Over a 5-year period, relevant clinical data including laboratory and lung function test results were gathered from the medical records of 95 sarcoidosis patients with persistent disabling symptoms who underwent both a PET and HRCT. HRCT scans were classified using a semiquantitative scoring system and PET findings as positive or negative, respectively. Results: PET was positive in 77/95 patients, of whom 56 demonstrated pulmonary PET-positivity. HRCT scores were high (7.1 +/- 3.6) in patients with positive pulmonary PET findings (n = 56) compared to patients with negative pulmonary PET findings (n = 39; 3.0 +/- 2.9; p",

keywords = "Sarcoidosis, HRCT, PET, FDG, Lung function, Inflammatory activity",

author = "Mostard, {Remy L. M.} and Verschakelen, {Johny A.} and {van Kroonenburgh}, {Marinus J. P. G.} and Nelemans, {Patty J.} and Wijnen, {Petal A. H. M.} and Stefan Voo and Marjolein Drent",

year = "2013",

month = mar,

doi = "10.1016/j.rmed.2012.11.011",

language = "English",

volume = "107",

pages = "439--447",

journal = "Respiratory Medicine",

issn = "0954-6111",

publisher = "Elsevier Saunders",

number = "3",

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TY - JOUR

T1 - Severity of pulmonary involvement and F-18-FDG PET activity in sarcoidosis

AU - Mostard, Remy L. M.

AU - Verschakelen, Johny A.

AU - van Kroonenburgh, Marinus J. P. G.

AU - Nelemans, Patty J.

AU - Wijnen, Petal A. H. M.

AU - Voo, Stefan

AU - Drent, Marjolein

PY - 2013/3

Y1 - 2013/3

N2 - Background: Assessing inflammatory activity is useful in the management of persistent symptomatic sarcoidosis patients. F-18-FDG PET (PET) has been shown to be a sensitive technique to assess inflammatory activity in sarcoidosis. The aim of this study was to evaluate whether the severity of pulmonary involvement is associated with PET activity in persistent symptomatic sarcoidosis patients. Methods: Over a 5-year period, relevant clinical data including laboratory and lung function test results were gathered from the medical records of 95 sarcoidosis patients with persistent disabling symptoms who underwent both a PET and HRCT. HRCT scans were classified using a semiquantitative scoring system and PET findings as positive or negative, respectively. Results: PET was positive in 77/95 patients, of whom 56 demonstrated pulmonary PET-positivity. HRCT scores were high (7.1 +/- 3.6) in patients with positive pulmonary PET findings (n = 56) compared to patients with negative pulmonary PET findings (n = 39; 3.0 +/- 2.9; p

AB - Background: Assessing inflammatory activity is useful in the management of persistent symptomatic sarcoidosis patients. F-18-FDG PET (PET) has been shown to be a sensitive technique to assess inflammatory activity in sarcoidosis. The aim of this study was to evaluate whether the severity of pulmonary involvement is associated with PET activity in persistent symptomatic sarcoidosis patients. Methods: Over a 5-year period, relevant clinical data including laboratory and lung function test results were gathered from the medical records of 95 sarcoidosis patients with persistent disabling symptoms who underwent both a PET and HRCT. HRCT scans were classified using a semiquantitative scoring system and PET findings as positive or negative, respectively. Results: PET was positive in 77/95 patients, of whom 56 demonstrated pulmonary PET-positivity. HRCT scores were high (7.1 +/- 3.6) in patients with positive pulmonary PET findings (n = 56) compared to patients with negative pulmonary PET findings (n = 39; 3.0 +/- 2.9; p

KW - Sarcoidosis

KW - HRCT

KW - PET

KW - FDG

KW - Lung function

KW - Inflammatory activity

U2 - 10.1016/j.rmed.2012.11.011

DO - 10.1016/j.rmed.2012.11.011

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SN - 0954-6111

VL - 107

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EP - 447

JO - Respiratory Medicine

JF - Respiratory Medicine

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