Severe seizures as a side effect of deep brain stimulation in the dorsal peduncular cortex in a rat model of depression

Milaine Roet*, Sylvana Pol, Frederic L. W. V. J. Schaper, Govert Hoogland, Ali Jahanshahi, Yasin Temel*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Deep brain stimulation (DBS) has shown to have antidepressant effects in both human trials and animal studies. However, the optimal target and the underlying therapeutic mechanisms remain to be determined. In this study, we investigated if high frequency (HF) DBS in the dorsal peduncular cortex (DPC) alleviates depressive-like behavior in an experimental model of depression. Surprisingly, HF DBS in the DPC caused acute induction of seizures in similar to 40% of animals stimulated with clinically relevant stimulation parameters. Reducing the stimulation's amplitude by 50% did not alter seizure occurrence. Electroencephalographic (EEG) recordings showed seizures up to Racine stage IV lasting up to 4 min after cessation of stimulation. We conclude that HF DBS in the DPC is not suitable for mood-related experiments in rats but could be a potential model for seizure induction. (C) 2019 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)269-275
Number of pages7
JournalEpilepsy & Behavior
Publication statusPublished - Mar 2019


  • High frequency (HF)
  • Deep brain stimulation (DBS)
  • Ventromedial prefrontal cortex (vmPFC)
  • Dorsal peduncular cortex (DPC)
  • Seizure
  • FEAR

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