Severe mitral regurgitation caused by eosinophilic endocarditis

Martinus van Dongen, Dave van Kraaij, Simon Schalla, Hanspeter Brunner-La Rocca, Rob Driessen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


We describe a patient with symptoms of heart failure caused by severe mitral regurgitation. Echocardiography revealed an intracardiac mass embedding the posterior mitral valve leaflet, and cardiac magnetic resonance imaging showed two intracardiac thrombi and endomyocardial fibrosis. Eosinophil count kept rising and a mutation in the gene for platelet-derived growth factor receptor alpha was found. The combination of these findings led to the diagnosis of Loeffler's endocarditis. Treatment with prednisone and a tyrosine kinase inhibitor resulted in complete remission of the hypereosinophilia and mitral valve regurgitation was only mild at 9-month follow-up visit. .
Original languageEnglish
JournalJournal of Cardiology Cases
Issue number3
Publication statusPublished - 2014


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