TY - JOUR
T1 - Serum Matrix Metalloproteinases and Left Atrial Remodeling-The Hoorn Study
AU - Linssen, Pauline B. C.
AU - Brunner-La Rocca, Hans-Peter
AU - Schalkwijk, Casper G.
AU - Beulens, Joline W. J.
AU - Elders, Petra J. M.
AU - Van der Heijden, Amber A.
AU - Slieker, Roderick C.
AU - Stehouwer, Coen D. A.
AU - Henry, Ronald M. A.
N1 - Funding Information:
Conflicts of Interest: P. Linssen, C. Schalkwijk, P. Elders, A van der Heijden, R. Slieker, C. Stehouwer, and R. Henry have nothing to disclose. Dr. H.-P. Brunner-La Rocca reports unrestricted research grants from Roche Diagnostics, Vifor and Novartis and serves as member of the advisory board of Roche Diagnostics, Vifor and Novartis outside the submitted work. J. Beulens is supported by a ZonMw VIDI-grant (grant number 91718304).
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/7/2
Y1 - 2020/7/2
N2 - Extracellular matrix protein turnover may play an important role in left atrial (LA) remodelling. The aim is to investigate the associations between matrix metalloproteinase (MMPs), tissue inhibitor of metalloproteinase (TIMP-1) and LA volume index (LAVI) and if these associations are independent of TIMP-1 levels. Participants from The Hoorn Study, a population-based cohort study (n= 674), underwent echocardiography. Serum MMPs (i.e., MMP-1, MMP-2, MMP-3, MMP-9, and MMP-10) and TIMP-1 levels were measured with ELISA. Multiple linear regression analyses were used. MMP-1 levels were not associated with LAVI. Higher MMP-2 levels were associated with larger LAVI (regression coefficient per SD increase in MMP (95% CI); 0.03 (0.01; 0.05). Higher MMP-3 and MMP-9 levels were associated with smaller LAVI; -0.04 (-0.07; -0.01) and -0.04 (-0.06; -0.02) respectively. Only in women were higher MMP-10 levels associated with larger LAVI; 0.04 (0.00; 0.07,p-interaction 0.04). Additionally, only in women were higher TIMP-1 levels associated with smaller LAVI; -0.05 (-0.09; -0.01,p-interaction 0.03). The associations between MMPs and LAVI were independent of TIMP-1 levels. In conclusion, serum MMPs are associated with LAVI, independent of CVD risk factors and TIMP-1 levels. In addition, these associations differ according to sex and within MMP subgroups. This shows that the role of MMPs in LA remodelling is complex.
AB - Extracellular matrix protein turnover may play an important role in left atrial (LA) remodelling. The aim is to investigate the associations between matrix metalloproteinase (MMPs), tissue inhibitor of metalloproteinase (TIMP-1) and LA volume index (LAVI) and if these associations are independent of TIMP-1 levels. Participants from The Hoorn Study, a population-based cohort study (n= 674), underwent echocardiography. Serum MMPs (i.e., MMP-1, MMP-2, MMP-3, MMP-9, and MMP-10) and TIMP-1 levels were measured with ELISA. Multiple linear regression analyses were used. MMP-1 levels were not associated with LAVI. Higher MMP-2 levels were associated with larger LAVI (regression coefficient per SD increase in MMP (95% CI); 0.03 (0.01; 0.05). Higher MMP-3 and MMP-9 levels were associated with smaller LAVI; -0.04 (-0.07; -0.01) and -0.04 (-0.06; -0.02) respectively. Only in women were higher MMP-10 levels associated with larger LAVI; 0.04 (0.00; 0.07,p-interaction 0.04). Additionally, only in women were higher TIMP-1 levels associated with smaller LAVI; -0.05 (-0.09; -0.01,p-interaction 0.03). The associations between MMPs and LAVI were independent of TIMP-1 levels. In conclusion, serum MMPs are associated with LAVI, independent of CVD risk factors and TIMP-1 levels. In addition, these associations differ according to sex and within MMP subgroups. This shows that the role of MMPs in LA remodelling is complex.
KW - matrix metalloproteinase (MMPs)
KW - tissue inhibitor of matrix metalloproteinases (TIMP-1)
KW - LA-volume index
KW - diastolic dysfunction
KW - echocardiography
KW - HEART-FAILURE
KW - CHAMBER QUANTIFICATION
KW - EUROPEAN-ASSOCIATION
KW - TISSUE INHIBITORS
KW - AMERICAN-SOCIETY
KW - VOLUME INDEX
KW - RISK
KW - INFLAMMATION
KW - POPULATION
KW - MATRIX-METALLOPROTEINASE-9
U2 - 10.3390/ijms21144944
DO - 10.3390/ijms21144944
M3 - Article
C2 - 32668720
SN - 1661-6596
VL - 21
JO - International journal of molecular sciences
JF - International journal of molecular sciences
IS - 14
M1 - 4944
ER -