Serum beta-glucuronidase activity in a population of ex-coalminers.

N.A.M. Cobben; M. Drent; J. de Vries; E.F.M. Wouters; M.P. van Dieijen-Visser; R.F. Henderson

doi:10.1016/S0009-9120(99)00070-3

Serum beta-glucuronidase activity in a population of ex-coalminers.

N.A.M. Cobben
, M. Drent^*
, J. de Vries
, E.F.M. Wouters
, M.P. van Dieijen-Visser
, R.F. Henderson

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Department of Pulmonology, University Hospital Maastricht, The Netherlands.

BACKGROUND: The aim of this study was to investigate whether BGD activity is of additional value in the assessment of pulmonary inflammation caused by coal dust exposure. DESIGN AND METHODS: Ex-coalminers were included in this study. Forty-eight healthy male subjects, without a relevant medical history, were used as controls. RESULTS: In ex-coalminers serum BGD activity was higher compared to the control group. Moreover, ex-coalminers with a normal chest radiograph and normal serum LDH demonstrated elevated serum BGD compared to the control group. However, no relation was found in the total group of ex-coalminers between serum BGD activity and pulmonary function parameters. CONCLUSIONS: Our study adds in vivo human evidence to the already existing animal data that BGD is a potential biomarker useful in monitoring pulmonary inflammation caused by coal dust exposure.

Original language	English
Pages (from-to)	659-664
Number of pages	6
Journal	Clinical Biochemistry
Volume	32
Issue number	8
DOIs	https://doi.org/10.1016/S0009-9120(99)00070-3
Publication status	Published - 1 Jan 1999

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10.1016/S0009-9120(99)00070-3

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title = "Serum beta-glucuronidase activity in a population of ex-coalminers.",

abstract = "Department of Pulmonology, University Hospital Maastricht, The Netherlands. BACKGROUND: The aim of this study was to investigate whether BGD activity is of additional value in the assessment of pulmonary inflammation caused by coal dust exposure. DESIGN AND METHODS: Ex-coalminers were included in this study. Forty-eight healthy male subjects, without a relevant medical history, were used as controls. RESULTS: In ex-coalminers serum BGD activity was higher compared to the control group. Moreover, ex-coalminers with a normal chest radiograph and normal serum LDH demonstrated elevated serum BGD compared to the control group. However, no relation was found in the total group of ex-coalminers between serum BGD activity and pulmonary function parameters. CONCLUSIONS: Our study adds in vivo human evidence to the already existing animal data that BGD is a potential biomarker useful in monitoring pulmonary inflammation caused by coal dust exposure.",

author = "N.A.M. Cobben and M. Drent and \{de Vries\}, J. and E.F.M. Wouters and \{van Dieijen-Visser\}, M.P. and R.F. Henderson",

year = "1999",

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doi = "10.1016/S0009-9120(99)00070-3",

language = "English",

volume = "32",

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journal = "Clinical Biochemistry",

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TY - JOUR

T1 - Serum beta-glucuronidase activity in a population of ex-coalminers.

AU - Cobben, N.A.M.

AU - Drent, M.

AU - de Vries, J.

AU - Wouters, E.F.M.

AU - van Dieijen-Visser, M.P.

AU - Henderson, R.F.

PY - 1999/1/1

Y1 - 1999/1/1

N2 - Department of Pulmonology, University Hospital Maastricht, The Netherlands. BACKGROUND: The aim of this study was to investigate whether BGD activity is of additional value in the assessment of pulmonary inflammation caused by coal dust exposure. DESIGN AND METHODS: Ex-coalminers were included in this study. Forty-eight healthy male subjects, without a relevant medical history, were used as controls. RESULTS: In ex-coalminers serum BGD activity was higher compared to the control group. Moreover, ex-coalminers with a normal chest radiograph and normal serum LDH demonstrated elevated serum BGD compared to the control group. However, no relation was found in the total group of ex-coalminers between serum BGD activity and pulmonary function parameters. CONCLUSIONS: Our study adds in vivo human evidence to the already existing animal data that BGD is a potential biomarker useful in monitoring pulmonary inflammation caused by coal dust exposure.

AB - Department of Pulmonology, University Hospital Maastricht, The Netherlands. BACKGROUND: The aim of this study was to investigate whether BGD activity is of additional value in the assessment of pulmonary inflammation caused by coal dust exposure. DESIGN AND METHODS: Ex-coalminers were included in this study. Forty-eight healthy male subjects, without a relevant medical history, were used as controls. RESULTS: In ex-coalminers serum BGD activity was higher compared to the control group. Moreover, ex-coalminers with a normal chest radiograph and normal serum LDH demonstrated elevated serum BGD compared to the control group. However, no relation was found in the total group of ex-coalminers between serum BGD activity and pulmonary function parameters. CONCLUSIONS: Our study adds in vivo human evidence to the already existing animal data that BGD is a potential biomarker useful in monitoring pulmonary inflammation caused by coal dust exposure.

U2 - 10.1016/S0009-9120(99)00070-3

DO - 10.1016/S0009-9120(99)00070-3

M3 - Article

SN - 0009-9120

VL - 32

SP - 659

EP - 664

JO - Clinical Biochemistry

JF - Clinical Biochemistry

IS - 8

ER -

Serum beta-glucuronidase activity in a population of ex-coalminers.

Abstract

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