Serum BDNF Concentrations Show Strong Seasonal Variation and Correlations with the Amount of Ambient Sunlight

Marc L. Molendijk*, Judith P. M. Haffmans, Boudewijn A. A. Bus, Philip Spinhoven, Brenda W. J. H. Penninx, Jos Prickaerts, Richard C. Oude Voshaar, Bernet M. Elzinga

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

53 Citations (Web of Science)


Earlier findings show seasonality in processes and behaviors such as brain plasticity and depression that in part are regulated by Brain-Derived Neurotrophic Factor (BDNF). Based on this we investigated seasonal variation in serum BDNF concentrations in 2,851 persons who took part in the Netherlands Study of Depression and Anxiety (NESDA). Analyses by month of sampling (monthly n's >196) showed pronounced seasonal variation in serum BDNF concentrations (P
Original languageEnglish
Article numbere48046
Issue number11
Publication statusPublished - 2 Nov 2012

Cite this