Serum BDNF Concentrations Show Strong Seasonal Variation and Correlations with the Amount of Ambient Sunlight

Marc L. Molendijk*, Judith P. M. Haffmans, Boudewijn A. A. Bus, Philip Spinhoven, Brenda W. J. H. Penninx, Jos Prickaerts, Richard C. Oude Voshaar, Bernet M. Elzinga

*Corresponding author for this work

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Abstract

Earlier findings show seasonality in processes and behaviors such as brain plasticity and depression that in part are regulated by Brain-Derived Neurotrophic Factor (BDNF). Based on this we investigated seasonal variation in serum BDNF concentrations in 2,851 persons who took part in the Netherlands Study of Depression and Anxiety (NESDA). Analyses by month of sampling (monthly n's >196) showed pronounced seasonal variation in serum BDNF concentrations (P
Original languageEnglish
Article numbere48046
JournalPLOS ONE
Volume7
Issue number11
DOIs
Publication statusPublished - 2 Nov 2012

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