Sentinel node in ovarian cancer: study protocol for a phase 1 study

Marjolein Kleppe, Toon Van Gorp, Brigitte F. M. Slangen, Arnold J. Kruse, Boudewijn Brans, Ivo N. A. Pooters, Koen K. Van de Vijver, Roy F. P. M. Kruitwagen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Background: The concept of sentinel lymph node surgery is to determine whether the cancer has spread to the very first lymph node or sentinel node. If the sentinel node does not contain cancer, then there is a high likelihood that the cancer has not spread to other lymph nodes. The sentinel node technique has been proven to be effective in different types of cancer. In this study we want to determine whether a sentinel node procedure in patients with ovarian cancer is feasible when the tracers are injected into the ovarian ligaments. Methods/Design: Patients with a high likelihood of having an ovarian malignancy in whom a median laparotomy and a frozen section analysis is planned and patients with endometrial cancer in whom a staging laparotomy is planned will be included. Before starting the surgical staging procedure, blue dye and radioactive colloid will be injected into the ligamentum ovarii proprium and the ligamentum infundibulo-pelvicum. In the analysis we calculate the percentage of patients in whom it is feasible to identify sentinel nodes. Other study parameters are the anatomical localization of the sentinel node(s) and the incidence of false negative lymph nodes.
Original languageEnglish
Article number47
Publication statusPublished - 15 Feb 2013


  • Sentinel node
  • Ovarian cancer

Cite this