TY - CHAP
T1 - Semantic Harmonization Workflow of Health Data
T2 - Application in the Post-COVID Network Netherlands
AU - Hasannejadasl, Hajar
AU - Zhang, Shuxin
AU - Boxma-De Klerk, Bianca M.
AU - Bosch, Jos
AU - Cornet, Ronald
AU - van Kuijk, Sander M.J.
N1 - Publisher Copyright:
© 2026 The Authors.
PY - 2026/5/21
Y1 - 2026/5/21
N2 - Semantic interoperability in multi-source health datasets is a key barrier to data integration and reuse in biomedical research. FAIR principles promote standardization, but operationalizing them for heterogeneous clinical and patient-reported data remains challenging. We introduced a structured workflow that yields metadata-rich codebooks to support semantic interoperability. It integrates manual curation, expert-driven semantic annotation using biomedical ontologies and contextual suffixes for measurement nuances. The workflow was applied to the Post-COVID Network Netherlands (PCNN) dataset. In a representative PCNN subset, we harmonized variables across domains like demographics, COVID-19 history, and questionnaires. Mappings are designed for expert review to ensure accuracy and reproducibility.
AB - Semantic interoperability in multi-source health datasets is a key barrier to data integration and reuse in biomedical research. FAIR principles promote standardization, but operationalizing them for heterogeneous clinical and patient-reported data remains challenging. We introduced a structured workflow that yields metadata-rich codebooks to support semantic interoperability. It integrates manual curation, expert-driven semantic annotation using biomedical ontologies and contextual suffixes for measurement nuances. The workflow was applied to the Post-COVID Network Netherlands (PCNN) dataset. In a representative PCNN subset, we harmonized variables across domains like demographics, COVID-19 history, and questionnaires. Mappings are designed for expert review to ensure accuracy and reproducibility.
KW - FAIR principles
KW - health data
KW - ontology mapping
KW - Post-COVID
KW - semantic interoperability
U2 - 10.3233/SHTI260692
DO - 10.3233/SHTI260692
M3 - Chapter
VL - 336
T3 - Studies in Health Technology and Informatics
SP - 2359
EP - 2363
BT - Opening the Personal Gate between Technology and Health Care - Proceedings of MIE 2026
A2 - Hagglund, Maria
A2 - Lindskold, Lars
A2 - Lhotska, Lenka
A2 - Marceglia, Sara
A2 - Parimbelli, Enea
A2 - Sacchi, Lucia
A2 - Soda, Paolo
A2 - Stoicu-Tivadar, Lacramioara
A2 - Veltri, Pierangelo
A2 - Vizza, Patrizia
A2 - Giacomini, Mauro
A2 - Delgado, Jaime
A2 - Arvanitis, Theodoros N.
A2 - Andrikopoulou, Elisavet
A2 - Benis, Arriel
A2 - Balestra, Gabriella
A2 - Bellazzi, Riccardo
A2 - Gallos, Parisis G.
A2 - Gatta, Roberto
A2 - Giacobbe, Daniele Roberto
A2 - Giordano, Noemi
PB - IOS Press
ER -