Self-reported long-term antiretroviral adherence: A longitudinal study among HIV infected pregnant women in Mpumalanga, South Africa

Shandir Ramlagan; Violeta J. Rodriguez; Karl Peltzer; Robert A. C. Ruiter; Deborah L. Jones; Sibusiso Sifunda

doi:10.1007/s10461-019-02563-z

Self-reported long-term antiretroviral adherence: A longitudinal study among HIV infected pregnant women in Mpumalanga, South Africa

Shandir Ramlagan^*, Violeta J. Rodriguez, Karl Peltzer, Robert A. C. Ruiter, Deborah L. Jones, Sibusiso Sifunda

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We evaluate the impact of a multi-session cognitive behavioral prevention of mother to child transmission (PMTCT) intervention on antiretroviral therapy (ART) adherence. A total of 683 women were enrolled into a randomized control trial conducted at twelve community health centres (CHCs) in Mpumalanga Province. Participants were randomized to Standard Care or Enhanced PMTCT Intervention (EI). EI received three group and three individual intervention sessions. EI impact was ascertained on ART adherence (baseline vs 12 months post-partum). Women in the intervention groups were less likely to remain stable with regards to ART adherence over time compared to the control groups. In predicting if women become adherent over time, the intervention condition had no impact. However, the intervention condition was significantly positively associated with change to non-adherence. The enhanced cognitive-behavioral PMTCT intervention did not show any improvement in relation to maternal ART adherence relative to standard PMTCT care.

Original language	English
Pages (from-to)	2576-2587
Number of pages	12
Journal	Aids and Behavior
Volume	23
Issue number	9
DOIs	https://doi.org/10.1007/s10461-019-02563-z
Publication status	Published - Sept 2019

Keywords

ART adherence
Maternal
Pregnancy
South Africa
Randomized Control Trial
POSTNATAL DEPRESSION
NECESSITY
THERAPY
POSTPARTUM
VIOLENCE
BELIEFS
STIGMA
SCALE

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Cite this

@article{5d8d445f2f1f4cb3a743e4c7b9395b02,

title = "Self-reported long-term antiretroviral adherence: A longitudinal study among HIV infected pregnant women in Mpumalanga, South Africa",

abstract = "We evaluate the impact of a multi-session cognitive behavioral prevention of mother to child transmission (PMTCT) intervention on antiretroviral therapy (ART) adherence. A total of 683 women were enrolled into a randomized control trial conducted at twelve community health centres (CHCs) in Mpumalanga Province. Participants were randomized to Standard Care or Enhanced PMTCT Intervention (EI). EI received three group and three individual intervention sessions. EI impact was ascertained on ART adherence (baseline vs 12 months post-partum). Women in the intervention groups were less likely to remain stable with regards to ART adherence over time compared to the control groups. In predicting if women become adherent over time, the intervention condition had no impact. However, the intervention condition was significantly positively associated with change to non-adherence. The enhanced cognitive-behavioral PMTCT intervention did not show any improvement in relation to maternal ART adherence relative to standard PMTCT care.",

keywords = "ART adherence, Maternal, Pregnancy, South Africa, Randomized Control Trial, POSTNATAL DEPRESSION, NECESSITY, THERAPY, POSTPARTUM, VIOLENCE, BELIEFS, STIGMA, SCALE",

author = "Shandir Ramlagan and Rodriguez, {Violeta J.} and Karl Peltzer and Ruiter, {Robert A. C.} and Jones, {Deborah L.} and Sibusiso Sifunda",

note = "Publisher Copyright: {\textcopyright} 2019, The Author(s).",

year = "2019",

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T1 - Self-reported long-term antiretroviral adherence

T2 - A longitudinal study among HIV infected pregnant women in Mpumalanga, South Africa

AU - Ramlagan, Shandir

AU - Rodriguez, Violeta J.

AU - Peltzer, Karl

AU - Ruiter, Robert A. C.

AU - Jones, Deborah L.

AU - Sifunda, Sibusiso

PY - 2019/9

Y1 - 2019/9

N2 - We evaluate the impact of a multi-session cognitive behavioral prevention of mother to child transmission (PMTCT) intervention on antiretroviral therapy (ART) adherence. A total of 683 women were enrolled into a randomized control trial conducted at twelve community health centres (CHCs) in Mpumalanga Province. Participants were randomized to Standard Care or Enhanced PMTCT Intervention (EI). EI received three group and three individual intervention sessions. EI impact was ascertained on ART adherence (baseline vs 12 months post-partum). Women in the intervention groups were less likely to remain stable with regards to ART adherence over time compared to the control groups. In predicting if women become adherent over time, the intervention condition had no impact. However, the intervention condition was significantly positively associated with change to non-adherence. The enhanced cognitive-behavioral PMTCT intervention did not show any improvement in relation to maternal ART adherence relative to standard PMTCT care.

AB - We evaluate the impact of a multi-session cognitive behavioral prevention of mother to child transmission (PMTCT) intervention on antiretroviral therapy (ART) adherence. A total of 683 women were enrolled into a randomized control trial conducted at twelve community health centres (CHCs) in Mpumalanga Province. Participants were randomized to Standard Care or Enhanced PMTCT Intervention (EI). EI received three group and three individual intervention sessions. EI impact was ascertained on ART adherence (baseline vs 12 months post-partum). Women in the intervention groups were less likely to remain stable with regards to ART adherence over time compared to the control groups. In predicting if women become adherent over time, the intervention condition had no impact. However, the intervention condition was significantly positively associated with change to non-adherence. The enhanced cognitive-behavioral PMTCT intervention did not show any improvement in relation to maternal ART adherence relative to standard PMTCT care.

KW - ART adherence

KW - Maternal

KW - Pregnancy

KW - South Africa

KW - Randomized Control Trial

KW - POSTNATAL DEPRESSION

KW - NECESSITY

KW - THERAPY

KW - POSTPARTUM

KW - VIOLENCE

KW - BELIEFS

KW - STIGMA

KW - SCALE

U2 - 10.1007/s10461-019-02563-z

DO - 10.1007/s10461-019-02563-z

M3 - Article

SN - 1090-7165

VL - 23

SP - 2576

EP - 2587

JO - Aids and Behavior

JF - Aids and Behavior

IS - 9

ER -