Selective striatal neuron loss and alterations in behavior correlate with impaired striatal function in Huntington's disease transgenic rats

O. Kantor; Y. Temel; C. Holzmann; K. Raber; H.P. Nguyen; C. Cao; H.O. Turkoglu; B.P. Rutten; V. Visser-Vandewalle; H.W. Steinbusch; A. Blokland; H. Korr; O. Riess; S. von Horsten; C. Schmitz

doi:10.1016/j.nbd.2005.12.014

Selective striatal neuron loss and alterations in behavior correlate with impaired striatal function in Huntington's disease transgenic rats

O. Kantor, Y. Temel, C. Holzmann, K. Raber, H.P. Nguyen, C. Cao, H.O. Turkoglu, B.P. Rutten, V. Visser-Vandewalle, H.W. Steinbusch, A. Blokland, H. Korr, O. Riess, S. von Horsten, C. Schmitz^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by selective striatal neuron loss and motor, cognitive and affective disturbances. The present study aimed to test the hypothesis of adult-onset neuron loss in striatum and frontal cortical layer V as well as alterations in behavior pointing to impaired striatal function in a recently developed transgenic rat model of HD (tgHD rats) exhibiting enlarged ventricles, striatal atrophy and pycnotic pyramidal cells in frontal cortical layer V. High-precision design-based stereological analysis revealed a reduced mean total number of neurons in the striatum but not in frontal cortical layer V of 12-month-old tgHD rats compared with age-matched wild-type controls. No alterations in mean total numbers of striatal neurons were found in 6-month-old animals. Testing 14-month-old animals in a choice reaction time task indicated impaired striatal function of tgHD rats compared with controls.

Original language	English
Pages (from-to)	538-547
Journal	Neurobiology of Disease
Volume	22
DOIs	https://doi.org/10.1016/j.nbd.2005.12.014
Publication status	Published - 1 Jan 2006

Access to Document

10.1016/j.nbd.2005.12.014

Cite this

Kantor, O., Temel, Y., Holzmann, C., Raber, K., Nguyen, H. P., Cao, C., Turkoglu, H. O., Rutten, B. P., Visser-Vandewalle, V., Steinbusch, H. W., Blokland, A., Korr, H., Riess, O., von Horsten, S., & Schmitz, C. (2006). Selective striatal neuron loss and alterations in behavior correlate with impaired striatal function in Huntington's disease transgenic rats. Neurobiology of Disease, 22, 538-547. https://doi.org/10.1016/j.nbd.2005.12.014

Kantor, O. ; Temel, Y. ; Holzmann, C. ; Raber, K. ; Nguyen, H.P. ; Cao, C. ; Turkoglu, H.O. ; Rutten, B.P. ; Visser-Vandewalle, V. ; Steinbusch, H.W. ; Blokland, A. ; Korr, H. ; Riess, O. ; von Horsten, S. ; Schmitz, C. / Selective striatal neuron loss and alterations in behavior correlate with impaired striatal function in Huntington's disease transgenic rats. In: Neurobiology of Disease. 2006 ; Vol. 22. pp. 538-547.

@article{b77d8ef7e8634afba14b2fdc71951118,

title = "Selective striatal neuron loss and alterations in behavior correlate with impaired striatal function in Huntington's disease transgenic rats",

abstract = "Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by selective striatal neuron loss and motor, cognitive and affective disturbances. The present study aimed to test the hypothesis of adult-onset neuron loss in striatum and frontal cortical layer V as well as alterations in behavior pointing to impaired striatal function in a recently developed transgenic rat model of HD (tgHD rats) exhibiting enlarged ventricles, striatal atrophy and pycnotic pyramidal cells in frontal cortical layer V. High-precision design-based stereological analysis revealed a reduced mean total number of neurons in the striatum but not in frontal cortical layer V of 12-month-old tgHD rats compared with age-matched wild-type controls. No alterations in mean total numbers of striatal neurons were found in 6-month-old animals. Testing 14-month-old animals in a choice reaction time task indicated impaired striatal function of tgHD rats compared with controls. ",

author = "O. Kantor and Y. Temel and C. Holzmann and K. Raber and H.P. Nguyen and C. Cao and H.O. Turkoglu and B.P. Rutten and V. Visser-Vandewalle and H.W. Steinbusch and A. Blokland and H. Korr and O. Riess and {von Horsten}, S. and C. Schmitz",

year = "2006",

month = jan,

day = "1",

doi = "10.1016/j.nbd.2005.12.014",

language = "English",

volume = "22",

pages = "538--547",

journal = "Neurobiology of Disease",

issn = "0969-9961",

publisher = "Elsevier Science",

}

Kantor, O, Temel, Y, Holzmann, C, Raber, K, Nguyen, HP, Cao, C, Turkoglu, HO, Rutten, BP, Visser-Vandewalle, V, Steinbusch, HW , Blokland, A, Korr, H, Riess, O, von Horsten, S & Schmitz, C 2006, 'Selective striatal neuron loss and alterations in behavior correlate with impaired striatal function in Huntington's disease transgenic rats', Neurobiology of Disease, vol. 22, pp. 538-547. https://doi.org/10.1016/j.nbd.2005.12.014

Selective striatal neuron loss and alterations in behavior correlate with impaired striatal function in Huntington's disease transgenic rats. / Kantor, O.; Temel, Y.; Holzmann, C.; Raber, K.; Nguyen, H.P.; Cao, C.; Turkoglu, H.O.; Rutten, B.P.; Visser-Vandewalle, V.; Steinbusch, H.W.; Blokland, A.; Korr, H.; Riess, O.; von Horsten, S.; Schmitz, C.

In: Neurobiology of Disease, Vol. 22, 01.01.2006, p. 538-547.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Selective striatal neuron loss and alterations in behavior correlate with impaired striatal function in Huntington's disease transgenic rats

AU - Kantor, O.

AU - Temel, Y.

AU - Holzmann, C.

AU - Raber, K.

AU - Nguyen, H.P.

AU - Cao, C.

AU - Turkoglu, H.O.

AU - Rutten, B.P.

AU - Visser-Vandewalle, V.

AU - Steinbusch, H.W.

AU - Blokland, A.

AU - Korr, H.

AU - Riess, O.

AU - von Horsten, S.

AU - Schmitz, C.

PY - 2006/1/1

Y1 - 2006/1/1

N2 - Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by selective striatal neuron loss and motor, cognitive and affective disturbances. The present study aimed to test the hypothesis of adult-onset neuron loss in striatum and frontal cortical layer V as well as alterations in behavior pointing to impaired striatal function in a recently developed transgenic rat model of HD (tgHD rats) exhibiting enlarged ventricles, striatal atrophy and pycnotic pyramidal cells in frontal cortical layer V. High-precision design-based stereological analysis revealed a reduced mean total number of neurons in the striatum but not in frontal cortical layer V of 12-month-old tgHD rats compared with age-matched wild-type controls. No alterations in mean total numbers of striatal neurons were found in 6-month-old animals. Testing 14-month-old animals in a choice reaction time task indicated impaired striatal function of tgHD rats compared with controls.

AB - Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by selective striatal neuron loss and motor, cognitive and affective disturbances. The present study aimed to test the hypothesis of adult-onset neuron loss in striatum and frontal cortical layer V as well as alterations in behavior pointing to impaired striatal function in a recently developed transgenic rat model of HD (tgHD rats) exhibiting enlarged ventricles, striatal atrophy and pycnotic pyramidal cells in frontal cortical layer V. High-precision design-based stereological analysis revealed a reduced mean total number of neurons in the striatum but not in frontal cortical layer V of 12-month-old tgHD rats compared with age-matched wild-type controls. No alterations in mean total numbers of striatal neurons were found in 6-month-old animals. Testing 14-month-old animals in a choice reaction time task indicated impaired striatal function of tgHD rats compared with controls.

U2 - 10.1016/j.nbd.2005.12.014

DO - 10.1016/j.nbd.2005.12.014

M3 - Article

C2 - 16480885

VL - 22

SP - 538

EP - 547

JO - Neurobiology of Disease

JF - Neurobiology of Disease

SN - 0969-9961

ER -