Selection of patients for radiotherapy with protons aiming at reduction of side effects: The model-based approach

Johannes A. Langendijk*, Philippe Lambin, Dirk De Ruysscher, Joachim Widder, Mike Bos, Marcel Verheij

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

324 Citations (Web of Science)


Most new radiation techniques, have been introduced primarily to reduce the dose to normal tissues in order to prevent radiation-induced side effects. Radiotherapy with protons is such a radiation technique that due to its superior beam properties compared to photons enables better sparing of normal tissues. This paper describes a stepwise methodology to select patients for proton therapy when the primary aim is to reduce side effects. This method has been accepted by the Dutch health authorities to select patients for proton therapy. In addition, an alternative method is described in case randomised controlled trials are considered not appropriate.
Original languageEnglish
Pages (from-to)267-273
JournalRadiotherapy and Oncology
Issue number3
Publication statusPublished - Jun 2013


  • Proton therapy
  • Patient selection
  • Randomisation
  • NTCP-models

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