Abstract
Type 1 diabetes is a life-threatening disease that is hallmarked by an autoimmune response against the insulin-producing ß-cells in the pancreatic islets. Currently, clinical islet transplantation is the most promising minimal invasive therapy to treat the most severe cases of type 1 diabetes. Despite great progress in islet isolation and transplantation protocols in the last two decades, most patients are required to switch back to exogeneous insulin administration after several years post-transplantation. Bioengineering approaches through encapsulation of islets, or stem cell-derived ß-cells, can be used to support cells or offer novel implantation sites that could potentially improve the outcome of clinical islet transplantation. However, the selection of biomaterials for cell delivery is challenging since the tissue response to an implant can be influenced by a wide range of biomaterial characteristics. This chapter will therefore discuss the influence of biomaterial characteristics such as chemical composition, porosity, topography, mechanical properties, degradability, and functionalization on biomaterial biocompatibility. In addition, the importance of clean fabrication techniques and selection of biomaterials that allow for non-invasive monitoring of cell grafts are highlighted.
| Original language | English |
|---|---|
| Title of host publication | Pluripotent Stem Cell Therapy for Diabetes |
| Editors | Lorenzo Piemonti, Jon Odorico, Timothy J. Kieffer, Valeria Sordi, Eelco de Koning |
| Publisher | Springer, Cham |
| Pages | 97-121 |
| Number of pages | 25 |
| Edition | 1 |
| ISBN (Electronic) | 978-3-031-41943-0 |
| ISBN (Print) | 978-3-031-41942-3 |
| DOIs | |
| Publication status | Published - 1 Jan 2024 |
Keywords
- Biodegradation
- Biofunctionalization
- Biomaterials
- clinical grade fabrication techniques
- Islet delivery device
- Islet transplantation
- Mechanical properties
- non-invasive islet monitoring
- Oxidative stress
- Porosity
- Topography