Sedentary Behavior and Chronic Disease: Mechanisms and Future Directions

Paddy C. Dempsey*, Chuck E. Matthews, S. Ghazaleh Dashti, Aiden R. Doherty, Audrey Bergouignan, Eline H. van Roekel, David W. Dunstan, Nicholas J. Wareham, Thomas E. Yates, Katrien Wijndaele, Brigid M. Lynch

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

409 Downloads (Pure)

Abstract

Background: Recent updates to physical activity guidelines highlight the importance of reducing sedentary time. However, at present, only general recommendations are possible (ie, "Sit less, move more"). There remains a need to investigate the strength, temporality, specificity, and dose-response nature of sedentary behavior associations with chronic disease, along with potential underlying mechanisms. Methods: Stemming from a recent research workshop organized by the Sedentary Behavior Council themed "Sedentary behaviour mechanisms-biological and behavioural pathways linking sitting to adverse health outcomes," this paper (1) discusses existing challenges and scientific discussions within this advancing area of science, (2) highlights and discusses emerging areas of interest, and (3) points to potential future directions. Results: A brief knowledge update is provided, reflecting upon current and evolving thinking/discussions, and the rapid accumulation of new evidence linking sedentary behavior to chronic disease. Research "action points" are made at the end of each section-spanning from measurement systems and analytic methods, genetic epidemiology, causal mediation, and experimental studies to biological and behavioral determinants and mechanisms. Conclusion: A better understanding of whether and how sedentary behavior is causally related to chronic disease will allow for more meaningful conclusions in the future and assist in refining clinical and public health policies/recommendations.

Original languageEnglish
Pages (from-to)52-61
Number of pages10
JournalJournal of Physical Activity & Health
Volume17
Issue number1
DOIs
Publication statusPublished - Jan 2020

Keywords

  • sitting
  • exercise
  • physical activity
  • physiology
  • epidemiology
  • cardiometabolic
  • mediation
  • measurement
  • TIME-VARYING EXPOSURES
  • PHYSICAL-ACTIVITY
  • MEDIATION ANALYSIS
  • SITTING TIME
  • ENERGY-EXPENDITURE
  • OLDER-ADULTS
  • MORTALITY
  • HEALTH
  • CONSENSUS
  • PATTERNS

Fingerprint

Dive into the research topics of 'Sedentary Behavior and Chronic Disease: Mechanisms and Future Directions'. Together they form a unique fingerprint.

Cite this