Screening of Chlamydia trachomatis and Waddlia chondrophila Antibodies in Women with Tubal Factor Infertility

Wies T. M. van Dooremalen, Stephan P. Verweij, Janneke E. den Hartog, Carole Kebbi-Beghdadi, Sander Ouburg, Gilbert Greub, Servaas A. Morre, Anne Ammerdorffer*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Web of Science)

Abstract

Waddlia chondrophilais an emerging intracellular pathogen belonging to the order ofChlamydiales, and was previously associated with adverse pregnancy outcomes, as well as tubal factor infertility (TFI). In this study, we investigate the link between bothW. chondrophilaandChlamydia trachomatisIgG seropositivity and TFI. Antibodies against both bacteria were measured in 890 serum samples of women visiting a fertility clinic. After a hysterosalpingography and/or laparoscopy, they were classified as either TFI-negative (TFI-) or TFI-positive (TFI+). The total seroprevalence was 13.4% forC. trachomatisand 38.8% forW. chondrophila.C. trachomatisantibodies were present significantly more often in the TFI+ group than in the TFI- group, while forW. chondrophilano difference could be observed. In conclusion, our study confirms the association betweenC. trachomatisseropositivity and TFI, but no association was found betweenW. chondrophilaseropositivity and TFI. The high percentage ofW. chondrophilaseropositivity in all women attending a fertility clinic does, however, demonstrate the need for further research on thisChlamydia-like bacterium and its possible role in infertility.

Original languageEnglish
Article number918
Number of pages9
JournalMicroorganisms
Volume8
Issue number6
DOIs
Publication statusPublished - Jun 2020

Keywords

  • Waddlia chondrophila
  • Chlamydia trachomatis
  • tubal factor infertility
  • female reproductive health
  • serology
  • CHLAMYDIA-TRACHOMATIS
  • WADDLIA-CHONDROPHILA
  • ANTIBODIES
  • BACTERIA
  • PATHOGEN
  • BIOLOGY

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