TY - JOUR
T1 - Screening of Chlamydia trachomatis and Waddlia chondrophila Antibodies in Women with Tubal Factor Infertility
AU - van Dooremalen, Wies T. M.
AU - Verweij, Stephan P.
AU - den Hartog, Janneke E.
AU - Kebbi-Beghdadi, Carole
AU - Ouburg, Sander
AU - Greub, Gilbert
AU - Morre, Servaas A.
AU - Ammerdorffer, Anne
N1 - Funding Information:
Funding: Part of this research was supported by or in line with the following projects: Eurostars project SOL-CT (Eureka number E!11539), Globalstars project InPoChlam (Eureka number GS181005 E!13075), H2020-INNOSUP-02-2016 (739679).
Publisher Copyright:
© 2020 by the authors.
PY - 2020/6
Y1 - 2020/6
N2 - Waddlia chondrophilais an emerging intracellular pathogen belonging to the order ofChlamydiales, and was previously associated with adverse pregnancy outcomes, as well as tubal factor infertility (TFI). In this study, we investigate the link between bothW. chondrophilaandChlamydia trachomatisIgG seropositivity and TFI. Antibodies against both bacteria were measured in 890 serum samples of women visiting a fertility clinic. After a hysterosalpingography and/or laparoscopy, they were classified as either TFI-negative (TFI-) or TFI-positive (TFI+). The total seroprevalence was 13.4% forC. trachomatisand 38.8% forW. chondrophila.C. trachomatisantibodies were present significantly more often in the TFI+ group than in the TFI- group, while forW. chondrophilano difference could be observed. In conclusion, our study confirms the association betweenC. trachomatisseropositivity and TFI, but no association was found betweenW. chondrophilaseropositivity and TFI. The high percentage ofW. chondrophilaseropositivity in all women attending a fertility clinic does, however, demonstrate the need for further research on thisChlamydia-like bacterium and its possible role in infertility.
AB - Waddlia chondrophilais an emerging intracellular pathogen belonging to the order ofChlamydiales, and was previously associated with adverse pregnancy outcomes, as well as tubal factor infertility (TFI). In this study, we investigate the link between bothW. chondrophilaandChlamydia trachomatisIgG seropositivity and TFI. Antibodies against both bacteria were measured in 890 serum samples of women visiting a fertility clinic. After a hysterosalpingography and/or laparoscopy, they were classified as either TFI-negative (TFI-) or TFI-positive (TFI+). The total seroprevalence was 13.4% forC. trachomatisand 38.8% forW. chondrophila.C. trachomatisantibodies were present significantly more often in the TFI+ group than in the TFI- group, while forW. chondrophilano difference could be observed. In conclusion, our study confirms the association betweenC. trachomatisseropositivity and TFI, but no association was found betweenW. chondrophilaseropositivity and TFI. The high percentage ofW. chondrophilaseropositivity in all women attending a fertility clinic does, however, demonstrate the need for further research on thisChlamydia-like bacterium and its possible role in infertility.
KW - Waddlia chondrophila
KW - Chlamydia trachomatis
KW - tubal factor infertility
KW - female reproductive health
KW - serology
KW - CHLAMYDIA-TRACHOMATIS
KW - WADDLIA-CHONDROPHILA
KW - ANTIBODIES
KW - BACTERIA
KW - PATHOGEN
KW - BIOLOGY
U2 - 10.3390/microorganisms8060918
DO - 10.3390/microorganisms8060918
M3 - Article
C2 - 32560559
SN - 2076-2607
VL - 8
JO - Microorganisms
JF - Microorganisms
IS - 6
M1 - 918
ER -