Screening for distant metastases in patients with ipsilateral breast tumor recurrence: the impact of different imaging modalities on distant recurrence-free interval

Ingrid G. M. Poodt; Robert-Jan Schipper; Bianca T. A. de Greef; Guusje Vugts; Adriana J. G. Maaskant-Braat; Frits H. Jansen; Dirk N. J. Wyndaele; Adri C. Voogd; Grard A. P. Nieuwenhuijzen; R. M. H. Roumen; E. J. T. Luiten; E. J. T. Rutgers; M. T. F. D. Vrancken-Peeters; M. Bessems; J. M. Klaase; S. Muller; A. B. Francken; T. Van Dalen; S. A. Koopal; Y. L. J. Vissers; M. L. Smidt; J. W. S. Merkus; C. M. E. Contant; P. H. Veldman; E. M. H. Linthorst-Niers; J. R. van der Sijp; O. R. Guicherit; L. B. Koppert; A. M. Bosch; L. J. A. Strobbe; M. S. Schlooz-Vries; I. E. Arntz; J. A. van Essen; J. W. D. de Waard; B. C. Vrouenraets; B. van Ooijen; Sentinel Node And Recurrent Breast Cancer (SNARB) Research Group; Marjolein Smidt

doi:10.1007/s10549-019-05205-z

Screening for distant metastases in patients with ipsilateral breast tumor recurrence: the impact of different imaging modalities on distant recurrence-free interval

Ingrid G. M. Poodt^*, Robert-Jan Schipper, Bianca T. A. de Greef, Guusje Vugts, Adriana J. G. Maaskant-Braat, Frits H. Jansen, Dirk N. J. Wyndaele, Adri C. Voogd, Grard A. P. Nieuwenhuijzen, R. M. H. Roumen, E. J. T. Luiten, E. J. T. Rutgers, M. T. F. D. Vrancken-Peeters, M. Bessems, J. M. Klaase, S. Muller, A. B. Francken, T. Van Dalen, S. A. Koopal, Y. L. J. VissersM. L. Smidt, J. W. S. Merkus, C. M. E. Contant, P. H. Veldman, E. M. H. Linthorst-Niers, J. R. van der Sijp, O. R. Guicherit, L. B. Koppert, A. M. Bosch, L. J. A. Strobbe, M. S. Schlooz-Vries, I. E. Arntz, J. A. van Essen, J. W. D. de Waard, B. C. Vrouenraets, B. van Ooijen, Sentinel Node And Recurrent Breast Cancer (SNARB) Research Group, Marjolein Smidt

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

PurposeIn patients with ipsilateral breast tumor recurrence (IBTR), the detection of distant disease determines whether the intention of the treatment is curative or palliative. Therefore, adequate preoperative staging is imperative for optimal treatment planning. The aim of this study is to evaluate the impact of conventional imaging techniques, including chest X-ray and/or CT thorax-(abdomen), liver ultrasonography(US), and skeletal scintigraphy, on the distant recurrence-free interval (DRFI) in patients with IBTR, and to compare conventional imaging with F-18-FDG PET-CT or no imaging at all.MethodsThis study was exclusively based on the information available at time of diagnoses of IBTR. To adjust for differences in baseline characteristics between the three imaging groups, a propensity score (PS) weighted method was used.ResultsOf the 495 patients included in the study, 229 (46.3%) were staged with conventional imaging, 89 patients (19.8%) were staged with F-18-FDG PET-CT, and in 168 of the patients (33.9%) no imaging was used (N=168). After a follow-up of approximately 5 years, 14.5% of all patients developed a distant recurrence as first event after IBTR. After adjusting for the PS weights, the Cox regression analyses showed that the different staging methods had no significant impact on the DRFI.ConclusionsThis study showed a wide variation in the use of imaging modalities for staging IBTR patients in the Netherlands. After using PS weighting, no statistically significant impact of the different imaging modalities on DRFI was shown. Based on these results, it is not possible to recommend staging for distant metastases using F-18-FDG PET-CT over conventional imaging techniques.

Original language	English
Pages (from-to)	419-428
Number of pages	10
Journal	Breast Cancer Research and Treatment
Volume	175
Issue number	2
DOIs	https://doi.org/10.1007/s10549-019-05205-z
Publication status	Published - Jun 2019

Keywords

Breast cancer
Ipsilateral breast tumor recurrence
Preoperative screening
Conventional imaging
F-18-FDG PET-CT
Distant metastasis
Propensity score weight
POSITRON-EMISSION-TOMOGRAPHY
SURGICAL ADJUVANT BREAST
PROPENSITY SCORE
FDG-PET
LOCOREGIONAL RECURRENCES
COMPUTED-TOMOGRAPHY
CANCER PATIENTS
SENTINEL NODE
PROGNOSIS
ACCURACY

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Poodt, I. G. M., Schipper, R.-J., de Greef, B. T. A., Vugts, G., Maaskant-Braat, A. J. G., Jansen, F. H., Wyndaele, D. N. J., Voogd, A. C., Nieuwenhuijzen, G. A. P., Roumen, R. M. H., Luiten, E. J. T., Rutgers, E. J. T., Vrancken-Peeters, M. T. F. D., Bessems, M., Klaase, J. M., Muller, S., Francken, A. B., Van Dalen, T., Koopal, S. A., ... Smidt, M. (2019). Screening for distant metastases in patients with ipsilateral breast tumor recurrence: the impact of different imaging modalities on distant recurrence-free interval. Breast Cancer Research and Treatment, 175(2), 419-428. https://doi.org/10.1007/s10549-019-05205-z

@article{04b09bb64fb14c888f244a08ebd481ca,

title = "Screening for distant metastases in patients with ipsilateral breast tumor recurrence: the impact of different imaging modalities on distant recurrence-free interval",

abstract = "PurposeIn patients with ipsilateral breast tumor recurrence (IBTR), the detection of distant disease determines whether the intention of the treatment is curative or palliative. Therefore, adequate preoperative staging is imperative for optimal treatment planning. The aim of this study is to evaluate the impact of conventional imaging techniques, including chest X-ray and/or CT thorax-(abdomen), liver ultrasonography(US), and skeletal scintigraphy, on the distant recurrence-free interval (DRFI) in patients with IBTR, and to compare conventional imaging with F-18-FDG PET-CT or no imaging at all.MethodsThis study was exclusively based on the information available at time of diagnoses of IBTR. To adjust for differences in baseline characteristics between the three imaging groups, a propensity score (PS) weighted method was used.ResultsOf the 495 patients included in the study, 229 (46.3%) were staged with conventional imaging, 89 patients (19.8%) were staged with F-18-FDG PET-CT, and in 168 of the patients (33.9%) no imaging was used (N=168). After a follow-up of approximately 5 years, 14.5% of all patients developed a distant recurrence as first event after IBTR. After adjusting for the PS weights, the Cox regression analyses showed that the different staging methods had no significant impact on the DRFI.ConclusionsThis study showed a wide variation in the use of imaging modalities for staging IBTR patients in the Netherlands. After using PS weighting, no statistically significant impact of the different imaging modalities on DRFI was shown. Based on these results, it is not possible to recommend staging for distant metastases using F-18-FDG PET-CT over conventional imaging techniques.",

keywords = "Breast cancer, Ipsilateral breast tumor recurrence, Preoperative screening, Conventional imaging, F-18-FDG PET-CT, Distant metastasis, Propensity score weight, POSITRON-EMISSION-TOMOGRAPHY, SURGICAL ADJUVANT BREAST, PROPENSITY SCORE, FDG-PET, LOCOREGIONAL RECURRENCES, COMPUTED-TOMOGRAPHY, CANCER PATIENTS, SENTINEL NODE, PROGNOSIS, ACCURACY",

author = "Poodt, {Ingrid G. M.} and Robert-Jan Schipper and {de Greef}, {Bianca T. A.} and Guusje Vugts and Maaskant-Braat, {Adriana J. G.} and Jansen, {Frits H.} and Wyndaele, {Dirk N. J.} and Voogd, {Adri C.} and Nieuwenhuijzen, {Grard A. P.} and Roumen, {R. M. H.} and Luiten, {E. J. T.} and Rutgers, {E. J. T.} and Vrancken-Peeters, {M. T. F. D.} and M. Bessems and Klaase, {J. M.} and S. Muller and Francken, {A. B.} and {Van Dalen}, T. and Koopal, {S. A.} and Vissers, {Y. L. J.} and Smidt, {M. L.} and Merkus, {J. W. S.} and Contant, {C. M. E.} and Veldman, {P. H.} and Linthorst-Niers, {E. M. H.} and {van der Sijp}, {J. R.} and Guicherit, {O. R.} and Koppert, {L. B.} and Bosch, {A. M.} and Strobbe, {L. J. A.} and Schlooz-Vries, {M. S.} and Arntz, {I. E.} and {van Essen}, {J. A.} and {de Waard}, {J. W. D.} and Vrouenraets, {B. C.} and {van Ooijen}, B. and {Sentinel Node And Recurrent Breast Cancer (SNARB) Research Group} and Marjolein Smidt",

note = "Publisher Copyright: {\textcopyright} 2019, The Author(s).",

year = "2019",

month = jun,

doi = "10.1007/s10549-019-05205-z",

language = "English",

volume = "175",

pages = "419--428",

journal = "Breast Cancer Research and Treatment",

issn = "0167-6806",

publisher = "Springer",

number = "2",

}

Poodt, IGM, Schipper, R-J, de Greef, BTA, Vugts, G, Maaskant-Braat, AJG, Jansen, FH, Wyndaele, DNJ, Voogd, AC, Nieuwenhuijzen, GAP, Roumen, RMH, Luiten, EJT, Rutgers, EJT, Vrancken-Peeters, MTFD, Bessems, M, Klaase, JM, Muller, S, Francken, AB, Van Dalen, T, Koopal, SA, Vissers, YLJ, Smidt, ML, Merkus, JWS, Contant, CME, Veldman, PH, Linthorst-Niers, EMH, van der Sijp, JR, Guicherit, OR, Koppert, LB, Bosch, AM, Strobbe, LJA, Schlooz-Vries, MS, Arntz, IE, van Essen, JA, de Waard, JWD, Vrouenraets, BC, van Ooijen, B, Sentinel Node And Recurrent Breast Cancer (SNARB) Research Group & Smidt, M 2019, 'Screening for distant metastases in patients with ipsilateral breast tumor recurrence: the impact of different imaging modalities on distant recurrence-free interval', Breast Cancer Research and Treatment, vol. 175, no. 2, pp. 419-428. https://doi.org/10.1007/s10549-019-05205-z

Screening for distant metastases in patients with ipsilateral breast tumor recurrence: the impact of different imaging modalities on distant recurrence-free interval. / Poodt, Ingrid G. M.; Schipper, Robert-Jan; de Greef, Bianca T. A. et al.
In: Breast Cancer Research and Treatment, Vol. 175, No. 2, 06.2019, p. 419-428.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Screening for distant metastases in patients with ipsilateral breast tumor recurrence

T2 - the impact of different imaging modalities on distant recurrence-free interval

AU - Poodt, Ingrid G. M.

AU - Schipper, Robert-Jan

AU - de Greef, Bianca T. A.

AU - Vugts, Guusje

AU - Maaskant-Braat, Adriana J. G.

AU - Jansen, Frits H.

AU - Wyndaele, Dirk N. J.

AU - Voogd, Adri C.

AU - Nieuwenhuijzen, Grard A. P.

AU - Roumen, R. M. H.

AU - Luiten, E. J. T.

AU - Rutgers, E. J. T.

AU - Vrancken-Peeters, M. T. F. D.

AU - Bessems, M.

AU - Klaase, J. M.

AU - Muller, S.

AU - Francken, A. B.

AU - Van Dalen, T.

AU - Koopal, S. A.

AU - Vissers, Y. L. J.

AU - Smidt, M. L.

AU - Merkus, J. W. S.

AU - Contant, C. M. E.

AU - Veldman, P. H.

AU - Linthorst-Niers, E. M. H.

AU - van der Sijp, J. R.

AU - Guicherit, O. R.

AU - Koppert, L. B.

AU - Bosch, A. M.

AU - Strobbe, L. J. A.

AU - Schlooz-Vries, M. S.

AU - Arntz, I. E.

AU - van Essen, J. A.

AU - de Waard, J. W. D.

AU - Vrouenraets, B. C.

AU - van Ooijen, B.

AU - Sentinel Node And Recurrent Breast Cancer (SNARB) Research Group

AU - Smidt, Marjolein

PY - 2019/6

Y1 - 2019/6

N2 - PurposeIn patients with ipsilateral breast tumor recurrence (IBTR), the detection of distant disease determines whether the intention of the treatment is curative or palliative. Therefore, adequate preoperative staging is imperative for optimal treatment planning. The aim of this study is to evaluate the impact of conventional imaging techniques, including chest X-ray and/or CT thorax-(abdomen), liver ultrasonography(US), and skeletal scintigraphy, on the distant recurrence-free interval (DRFI) in patients with IBTR, and to compare conventional imaging with F-18-FDG PET-CT or no imaging at all.MethodsThis study was exclusively based on the information available at time of diagnoses of IBTR. To adjust for differences in baseline characteristics between the three imaging groups, a propensity score (PS) weighted method was used.ResultsOf the 495 patients included in the study, 229 (46.3%) were staged with conventional imaging, 89 patients (19.8%) were staged with F-18-FDG PET-CT, and in 168 of the patients (33.9%) no imaging was used (N=168). After a follow-up of approximately 5 years, 14.5% of all patients developed a distant recurrence as first event after IBTR. After adjusting for the PS weights, the Cox regression analyses showed that the different staging methods had no significant impact on the DRFI.ConclusionsThis study showed a wide variation in the use of imaging modalities for staging IBTR patients in the Netherlands. After using PS weighting, no statistically significant impact of the different imaging modalities on DRFI was shown. Based on these results, it is not possible to recommend staging for distant metastases using F-18-FDG PET-CT over conventional imaging techniques.

AB - PurposeIn patients with ipsilateral breast tumor recurrence (IBTR), the detection of distant disease determines whether the intention of the treatment is curative or palliative. Therefore, adequate preoperative staging is imperative for optimal treatment planning. The aim of this study is to evaluate the impact of conventional imaging techniques, including chest X-ray and/or CT thorax-(abdomen), liver ultrasonography(US), and skeletal scintigraphy, on the distant recurrence-free interval (DRFI) in patients with IBTR, and to compare conventional imaging with F-18-FDG PET-CT or no imaging at all.MethodsThis study was exclusively based on the information available at time of diagnoses of IBTR. To adjust for differences in baseline characteristics between the three imaging groups, a propensity score (PS) weighted method was used.ResultsOf the 495 patients included in the study, 229 (46.3%) were staged with conventional imaging, 89 patients (19.8%) were staged with F-18-FDG PET-CT, and in 168 of the patients (33.9%) no imaging was used (N=168). After a follow-up of approximately 5 years, 14.5% of all patients developed a distant recurrence as first event after IBTR. After adjusting for the PS weights, the Cox regression analyses showed that the different staging methods had no significant impact on the DRFI.ConclusionsThis study showed a wide variation in the use of imaging modalities for staging IBTR patients in the Netherlands. After using PS weighting, no statistically significant impact of the different imaging modalities on DRFI was shown. Based on these results, it is not possible to recommend staging for distant metastases using F-18-FDG PET-CT over conventional imaging techniques.

KW - Breast cancer

KW - Ipsilateral breast tumor recurrence

KW - Preoperative screening

KW - Conventional imaging

KW - F-18-FDG PET-CT

KW - Distant metastasis

KW - Propensity score weight

KW - POSITRON-EMISSION-TOMOGRAPHY

KW - SURGICAL ADJUVANT BREAST

KW - PROPENSITY SCORE

KW - FDG-PET

KW - LOCOREGIONAL RECURRENCES

KW - COMPUTED-TOMOGRAPHY

KW - CANCER PATIENTS

KW - SENTINEL NODE

KW - PROGNOSIS

KW - ACCURACY

U2 - 10.1007/s10549-019-05205-z

DO - 10.1007/s10549-019-05205-z

M3 - Article

C2 - 30955183

SN - 0167-6806

VL - 175

SP - 419

EP - 428

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

IS - 2

ER -

Screening for distant metastases in patients with ipsilateral breast tumor recurrence: the impact of different imaging modalities on distant recurrence-free interval

Abstract

Keywords

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