Sarcopenia in Advanced COPD Affects Cardiometabolic Risk Reduction by Short-Term High-intensity Pulmonary Rehabilitation

Narca Cebron Lipovec, Annemie M. W. J. Schols, Bram van den Borst, Rosanne J. H. C. G. Beijers, Tatjana Kosten, Daniel Omersa, Mitja Lainscak*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Objectives: Sarcopenia is common in chronic obstructive pulmonary disease (COPD) and may contribute to increased cardiometabolic risk. Interventions to reduce cardiometabolic risk in advanced COPD have been scarcely studied. We have investigated the cardiometabolic effect of a short-term high-intensity rehabilitation program in sarcopenic and nonsarcopenic patients with advanced COPD. Design: Prospective observational study. Setting: Inpatient 4-week short-term high-intensity pulmonary rehabilitation program at the University Clinic Golnik, Slovenia. Participants: 112 stable COPD patients (66 +/- 8 years, 85% GOLD III/IV, 66% men). Measurements: Blood biomarkers were assessed at baseline and after rehabilitation. Sarcopenia was assessed at baseline (skeletal muscle index
Original languageEnglish
Pages (from-to)814-820
JournalJournal of the American Medical Directors Association
Issue number9
Publication statusPublished - 1 Sept 2016


  • COPD
  • sarcopenia
  • cardiometabolic risk
  • pulmonary rehabilitation

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