Salivary flow measurements in a clinical setting: the Dutch consensus statement

Zainab Assy; Derk Hendrik Jan Jager; Henk S. Brand; Antoon J.M. Ligtenberg; Casper P. Bots; Konstantina Delli; Willemijn E. Schulte; Justin Pijpe; Jamie Alberga; Frank K.J. Leusink; Hanneke van Verseveld; Chryssa E. Papagianni; Raymond Pieters; Hanan Al Habobe; Liesbeth Haverkort; Víctor I. Madariaga; Doke J.M. Buurman; Nynke E. Skorpil; Bart van den Bergh; Wouter Kalk; Arjan Vissink; Floris J. Bikker; Marja L. Laine

doi:10.1007/s00784-026-07033-0

Salivary flow measurements in a clinical setting: the Dutch consensus statement

Zainab Assy^*
, Derk Hendrik Jan Jager
, Henk S. Brand
, Antoon J.M. Ligtenberg
, Casper P. Bots
, Konstantina Delli
, Willemijn E. Schulte
, Justin Pijpe
, Jamie Alberga
, Frank K.J. Leusink
, Hanneke van Verseveld
, Chryssa E. Papagianni
, Raymond Pieters
, Hanan Al Habobe
, Liesbeth Haverkort
, Víctor I. Madariaga
, Doke J.M. Buurman
, Nynke E. Skorpil
, Bart van den Bergh
, Wouter Kalk

Arjan Vissink, Floris J. Bikker, Marja L. Laine

^*Corresponding author for this work

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

Abstract

Uniform measurement of the salivary flow rate is crucial in diagnosing hyposalivation and hypersalivation. However, there is considerable variation in the methods used to assess salivary flow rates. This variation of collection methods makes it difficult to compare data and to set well-established threshold values for hypo- and hypersalivation. Therefore, there is a need for standardised methods to measure the salivary flow rates in a clinical setting. This study describes the Dutch consensus statement for measuring unstimulated and stimulated salivary flow rates in a clinical setting. This may help in the development of an international standardised protocol for the assessment of salivary flow rates in clinical settings.

Original language	English
Article number	377
Number of pages	11
Journal	Clinical Oral Investigations
Volume	30
Issue number	9
DOIs	https://doi.org/10.1007/s00784-026-07033-0
Publication status	Published - 1 Sept 2026

Keywords

Hypersalivation
Hyposalivation
Saliva
Saliva collection
Salivary flow rate
Salivation

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10.1007/s00784-026-07033-0

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Assy, Z., Jager, D. H. J., Brand, H. S., Ligtenberg, A. J. M., Bots, C. P., Delli, K., Schulte, W. E., Pijpe, J., Alberga, J., Leusink, F. K. J., van Verseveld, H., Papagianni, C. E., Pieters, R., Habobe, H. A., Haverkort, L., Madariaga, V. I., Buurman, D. J. M., Skorpil, N. E., van den Bergh, B., ... Laine, M. L. (2026). Salivary flow measurements in a clinical setting: the Dutch consensus statement. Clinical Oral Investigations, 30(9), Article 377. https://doi.org/10.1007/s00784-026-07033-0

@article{1e168ddb483247bf932837b2bce81f6a,

title = "Salivary flow measurements in a clinical setting: the Dutch consensus statement",

abstract = "Uniform measurement of the salivary flow rate is crucial in diagnosing hyposalivation and hypersalivation. However, there is considerable variation in the methods used to assess salivary flow rates. This variation of collection methods makes it difficult to compare data and to set well-established threshold values for hypo- and hypersalivation. Therefore, there is a need for standardised methods to measure the salivary flow rates in a clinical setting. This study describes the Dutch consensus statement for measuring unstimulated and stimulated salivary flow rates in a clinical setting. This may help in the development of an international standardised protocol for the assessment of salivary flow rates in clinical settings.",

keywords = "Hypersalivation, Hyposalivation, Saliva, Saliva collection, Salivary flow rate, Salivation",

author = "Zainab Assy and Jager, \{Derk Hendrik Jan\} and Brand, \{Henk S.\} and Ligtenberg, \{Antoon J.M.\} and Bots, \{Casper P.\} and Konstantina Delli and Schulte, \{Willemijn E.\} and Justin Pijpe and Jamie Alberga and Leusink, \{Frank K.J.\} and \{van Verseveld\}, Hanneke and Papagianni, \{Chryssa E.\} and Raymond Pieters and Habobe, \{Hanan Al\} and Liesbeth Haverkort and Madariaga, \{V{\'i}ctor I.\} and Buurman, \{Doke J.M.\} and Skorpil, \{Nynke E.\} and \{van den Bergh\}, Bart and Wouter Kalk and Arjan Vissink and Bikker, \{Floris J.\} and Laine, \{Marja L.\}",

note = "Funding Information: F.J. Bikker, M.L. Laine, V. I. Madariaga and A. Vissink are financially supported by a research grant from Health-Holland, Top Sector Life Sciences \& Health (R/011124.03.02). A. Vissink is a member of the European Reference Network ReCONNET. Funding Information: F.J. Bikker, M.L. Laine, V. I. Madariaga, and A. Vissink are financially supported by a research grant from Health-Holland, Top Sector Life Sciences \& Health (R/011124.03.02). A. Vissink is a member of the European Reference Network ReCONNET. Publisher Copyright: {\textcopyright} The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2026.",

year = "2026",

month = sep,

day = "1",

doi = "10.1007/s00784-026-07033-0",

language = "English",

volume = "30",

journal = "Clinical Oral Investigations",

issn = "1432-6981",

publisher = "Springer Verlag",

number = "9",

}

Assy, Z, Jager, DHJ, Brand, HS, Ligtenberg, AJM, Bots, CP, Delli, K, Schulte, WE, Pijpe, J, Alberga, J, Leusink, FKJ, van Verseveld, H, Papagianni, CE, Pieters, R, Habobe, HA, Haverkort, L, Madariaga, VI, Buurman, DJM, Skorpil, NE, van den Bergh, B, Kalk, W, Vissink, A, Bikker, FJ & Laine, ML 2026, 'Salivary flow measurements in a clinical setting: the Dutch consensus statement', Clinical Oral Investigations, vol. 30, no. 9, 377. https://doi.org/10.1007/s00784-026-07033-0

TY - JOUR

T1 - Salivary flow measurements in a clinical setting

T2 - the Dutch consensus statement

AU - Assy, Zainab

AU - Jager, Derk Hendrik Jan

AU - Brand, Henk S.

AU - Ligtenberg, Antoon J.M.

AU - Bots, Casper P.

AU - Delli, Konstantina

AU - Schulte, Willemijn E.

AU - Pijpe, Justin

AU - Alberga, Jamie

AU - Leusink, Frank K.J.

AU - van Verseveld, Hanneke

AU - Papagianni, Chryssa E.

AU - Pieters, Raymond

AU - Habobe, Hanan Al

AU - Haverkort, Liesbeth

AU - Madariaga, Víctor I.

AU - Buurman, Doke J.M.

AU - Skorpil, Nynke E.

AU - van den Bergh, Bart

AU - Kalk, Wouter

AU - Vissink, Arjan

AU - Bikker, Floris J.

AU - Laine, Marja L.

N1 - Funding Information: F.J. Bikker, M.L. Laine, V. I. Madariaga and A. Vissink are financially supported by a research grant from Health-Holland, Top Sector Life Sciences & Health (R/011124.03.02). A. Vissink is a member of the European Reference Network ReCONNET. Funding Information: F.J. Bikker, M.L. Laine, V. I. Madariaga, and A. Vissink are financially supported by a research grant from Health-Holland, Top Sector Life Sciences & Health (R/011124.03.02). A. Vissink is a member of the European Reference Network ReCONNET. Publisher Copyright: © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2026.

PY - 2026/9/1

Y1 - 2026/9/1

N2 - Uniform measurement of the salivary flow rate is crucial in diagnosing hyposalivation and hypersalivation. However, there is considerable variation in the methods used to assess salivary flow rates. This variation of collection methods makes it difficult to compare data and to set well-established threshold values for hypo- and hypersalivation. Therefore, there is a need for standardised methods to measure the salivary flow rates in a clinical setting. This study describes the Dutch consensus statement for measuring unstimulated and stimulated salivary flow rates in a clinical setting. This may help in the development of an international standardised protocol for the assessment of salivary flow rates in clinical settings.

AB - Uniform measurement of the salivary flow rate is crucial in diagnosing hyposalivation and hypersalivation. However, there is considerable variation in the methods used to assess salivary flow rates. This variation of collection methods makes it difficult to compare data and to set well-established threshold values for hypo- and hypersalivation. Therefore, there is a need for standardised methods to measure the salivary flow rates in a clinical setting. This study describes the Dutch consensus statement for measuring unstimulated and stimulated salivary flow rates in a clinical setting. This may help in the development of an international standardised protocol for the assessment of salivary flow rates in clinical settings.

KW - Hypersalivation

KW - Hyposalivation

KW - Saliva

KW - Saliva collection

KW - Salivary flow rate

KW - Salivation

U2 - 10.1007/s00784-026-07033-0

DO - 10.1007/s00784-026-07033-0

M3 - Comment/Letter to the editor

SN - 1432-6981

VL - 30

JO - Clinical Oral Investigations

JF - Clinical Oral Investigations

IS - 9

M1 - 377

ER -

Salivary flow measurements in a clinical setting: the Dutch consensus statement

Abstract

Keywords

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