Safety and T Cell Modulating Effects of High Dose Vitamin D-3 Supplementation in Multiple Sclerosis

Joost Smolders*, Evelyn Peelen, Marielle Thewissen, Jan Willem Cohen Tervaert, Paul Menheere, Raymond Hupperts, Jan Damoiseaux

*Corresponding author for this work

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A poor vitamin D status has been associated with a high disease activity of multiple sclerosis (MS). Recently, we described associations between vitamin D status and peripheral T cell characteristics in relapsing remitting MS (RRMS) patients. In the present study, we studied the effects of high dose vitamin D-3 supplementation on safety and T cell related outcome measures. Methodology/Principal Findings: Fifteen RRMS patients were supplemented with 20 000 IU/d vitamin D-3 for 12 weeks. Vitamin D and calcium metabolism were carefully monitored, and T cell characteristics were studied by flowcytometry. All patients finished the protocol without side-effects, hypercalcaemia, or hypercalciuria. The median vitamin D status increased from 50 nmol/L (31-175) at week 0 to 380 nmol/L (151-535) at week 12 (P
Original languageEnglish
Issue number12
Publication statusPublished - 13 Dec 2010

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