Safety and T Cell Modulating Effects of High Dose Vitamin D-3 Supplementation in Multiple Sclerosis

Joost Smolders; Evelyn Peelen; Marielle Thewissen; Jan Willem Cohen Tervaert; Paul Menheere; Raymond Hupperts; Jan Damoiseaux

doi:10.1371/journal.pone.0015235

Safety and T Cell Modulating Effects of High Dose Vitamin D-3 Supplementation in Multiple Sclerosis

Joost Smolders^*, Evelyn Peelen, Marielle Thewissen, Jan Willem Cohen Tervaert, Paul Menheere, Raymond Hupperts, Jan Damoiseaux

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

A poor vitamin D status has been associated with a high disease activity of multiple sclerosis (MS). Recently, we described associations between vitamin D status and peripheral T cell characteristics in relapsing remitting MS (RRMS) patients. In the present study, we studied the effects of high dose vitamin D-3 supplementation on safety and T cell related outcome measures. Methodology/Principal Findings: Fifteen RRMS patients were supplemented with 20 000 IU/d vitamin D-3 for 12 weeks. Vitamin D and calcium metabolism were carefully monitored, and T cell characteristics were studied by flowcytometry. All patients finished the protocol without side-effects, hypercalcaemia, or hypercalciuria. The median vitamin D status increased from 50 nmol/L (31-175) at week 0 to 380 nmol/L (151-535) at week 12 (P

Original language	English
Journal	PLOS ONE
Volume	5
Issue number	12
DOIs	https://doi.org/10.1371/journal.pone.0015235
Publication status	Published - 13 Dec 2010

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10.1371/journal.pone.0015235Licence: CC BY

Cite this

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title = "Safety and T Cell Modulating Effects of High Dose Vitamin D-3 Supplementation in Multiple Sclerosis",

abstract = "A poor vitamin D status has been associated with a high disease activity of multiple sclerosis (MS). Recently, we described associations between vitamin D status and peripheral T cell characteristics in relapsing remitting MS (RRMS) patients. In the present study, we studied the effects of high dose vitamin D-3 supplementation on safety and T cell related outcome measures. Methodology/Principal Findings: Fifteen RRMS patients were supplemented with 20 000 IU/d vitamin D-3 for 12 weeks. Vitamin D and calcium metabolism were carefully monitored, and T cell characteristics were studied by flowcytometry. All patients finished the protocol without side-effects, hypercalcaemia, or hypercalciuria. The median vitamin D status increased from 50 nmol/L (31-175) at week 0 to 380 nmol/L (151-535) at week 12 (P",

author = "Joost Smolders and Evelyn Peelen and Marielle Thewissen and Tervaert, {Jan Willem Cohen} and Paul Menheere and Raymond Hupperts and Jan Damoiseaux",

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T1 - Safety and T Cell Modulating Effects of High Dose Vitamin D-3 Supplementation in Multiple Sclerosis

AU - Smolders, Joost

AU - Peelen, Evelyn

AU - Thewissen, Marielle

AU - Tervaert, Jan Willem Cohen

AU - Menheere, Paul

AU - Hupperts, Raymond

AU - Damoiseaux, Jan

PY - 2010/12/13

Y1 - 2010/12/13

N2 - A poor vitamin D status has been associated with a high disease activity of multiple sclerosis (MS). Recently, we described associations between vitamin D status and peripheral T cell characteristics in relapsing remitting MS (RRMS) patients. In the present study, we studied the effects of high dose vitamin D-3 supplementation on safety and T cell related outcome measures. Methodology/Principal Findings: Fifteen RRMS patients were supplemented with 20 000 IU/d vitamin D-3 for 12 weeks. Vitamin D and calcium metabolism were carefully monitored, and T cell characteristics were studied by flowcytometry. All patients finished the protocol without side-effects, hypercalcaemia, or hypercalciuria. The median vitamin D status increased from 50 nmol/L (31-175) at week 0 to 380 nmol/L (151-535) at week 12 (P

AB - A poor vitamin D status has been associated with a high disease activity of multiple sclerosis (MS). Recently, we described associations between vitamin D status and peripheral T cell characteristics in relapsing remitting MS (RRMS) patients. In the present study, we studied the effects of high dose vitamin D-3 supplementation on safety and T cell related outcome measures. Methodology/Principal Findings: Fifteen RRMS patients were supplemented with 20 000 IU/d vitamin D-3 for 12 weeks. Vitamin D and calcium metabolism were carefully monitored, and T cell characteristics were studied by flowcytometry. All patients finished the protocol without side-effects, hypercalcaemia, or hypercalciuria. The median vitamin D status increased from 50 nmol/L (31-175) at week 0 to 380 nmol/L (151-535) at week 12 (P

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