Safety and efficacy of transarterial embolization of hepatocellular adenomas

B. van Rosmaleni*, A. J. Klompenhouwer, J. Jaap de Graeff, M. P. D. Haring, V. E. de Meijer, L. Rifai, S. Dokmak, A. Rawashdeh, M. Abu Hilal, M. C. de Jong, C. H. C. Dejong, M. Doukas, R. A. de Man, J. N. M. IJzermans, O. M. van Delden, J. Verheij, T. M. van Gulikl, Dutch Benign Liver Tumour Group

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Web of Science)

Abstract

Background Hepatocellular adenoma (HCA) larger than 5 cm in diameter has an increased risk of haemorrhage and malignant transformation, and is considered an indication for resection. As an alternative to resection, transarterial embolization (TAE) may play a role in prevention of complications of HCA, but its safety and efficacy are largely unknown. The aim of this study was to assess outcomes and postembolization effects of selective TAE in the management of HCA. Methods This retrospective, multicentre cohort study included patients aged at least 18 years, diagnosed with HCA and treated with TAE. Patient characteristics, 30-day complications, tumour size before and after TAE, symptoms before and after TAE, and need for secondary interventions were analysed. Results Overall, 59 patients with a median age of 33.5 years were included from six centres; 57 of the 59 patients were women. Median tumour size at time of TAE was 76 mm. Six of 59 patients (10 per cent) had a major complication (cyst formation or sepsis), which could be resolved with minimal therapy, but prolonged hospital stay. Thirty-four patients (58 per cent) were symptomatic at presentation. There were no significant differences in symptoms before TAE and symptoms evaluated in the short term (within 3 months) after TAE (P = 0 center dot 134). First follow-up imaging was performed a median of 5 center dot 5 months after TAE and showed a reduction in size to a median of 48 mm (P <0 center dot 001). Conclusion TAE is safe, can lead to adequate size reduction of HCA and, offers an alternative to resection in selected patients.

Original languageEnglish
Pages (from-to)1362-1371
Number of pages10
JournalBritish Journal of Surgery
Volume106
Issue number10
Early online date17 Jul 2019
DOIs
Publication statusPublished - Sep 2019

Keywords

  • FOCAL NODULAR HYPERPLASIA
  • BENIGN HEPATIC-TUMORS
  • LIVER-CELL ADENOMA
  • RISK-FACTORS
  • MOLECULAR CLASSIFICATION
  • RADIOFREQUENCY ABLATION
  • DIFFERENTIAL-DIAGNOSIS
  • MANAGEMENT
  • EPIDEMIOLOGY

Cite this