Safety and Efficacy of the Addition of Lapatinib to Perioperative Chemotherapy for Resectable HER2-Positive Gastroesophageal Adenocarcinoma: A Randomized Phase 2 Clinical Trial

Elizabeth C. Smyth; Samuel Rowley; Fay H. Cafferty; William Allum; Heike I. Grabsch; Sally Stenning; Andrew Wotherspoon; Derek Alderson; Tom Crosby; Was Mansoor; Justin S. Waters; Helen Neville-Webbe; Suzanne Darby; Jo Dent; Matthew Seymour; Joyce Thompson; Sharmila Sothi; Jane Blazeby; Ruth E. Langley; David Cunningham

doi:10.1001/jamaoncol.2019.1179

Safety and Efficacy of the Addition of Lapatinib to Perioperative Chemotherapy for Resectable HER2-Positive Gastroesophageal Adenocarcinoma: A Randomized Phase 2 Clinical Trial

Elizabeth C. Smyth, Samuel Rowley, Fay H. Cafferty, William Allum, Heike I. Grabsch, Sally Stenning, Andrew Wotherspoon, Derek Alderson, Tom Crosby, Was Mansoor, Justin S. Waters, Helen Neville-Webbe, Suzanne Darby, Jo Dent, Matthew Seymour, Joyce Thompson, Sharmila Sothi, Jane Blazeby, Ruth E. Langley, David Cunningham^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	1181-1187
Number of pages	7
Journal	JAMA Oncology
Volume	5
Issue number	8
DOIs	https://doi.org/10.1001/jamaoncol.2019.1179
Publication status	Published - Aug 2019

Keywords

GASTRIC-CANCER
HER2
ESOPHAGEAL

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10.1001/jamaoncol.2019.1179

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Smyth, E. C., Rowley, S., Cafferty, F. H., Allum, W., Grabsch, H. I., Stenning, S., Wotherspoon, A., Alderson, D., Crosby, T., Mansoor, W., Waters, J. S., Neville-Webbe, H., Darby, S., Dent, J., Seymour, M., Thompson, J., Sothi, S., Blazeby, J., Langley, R. E., & Cunningham, D. (2019). Safety and Efficacy of the Addition of Lapatinib to Perioperative Chemotherapy for Resectable HER2-Positive Gastroesophageal Adenocarcinoma: A Randomized Phase 2 Clinical Trial. JAMA Oncology, 5(8), 1181-1187. https://doi.org/10.1001/jamaoncol.2019.1179

Smyth, Elizabeth C. ; Rowley, Samuel ; Cafferty, Fay H. ; Allum, William ; Grabsch, Heike I. ; Stenning, Sally ; Wotherspoon, Andrew ; Alderson, Derek ; Crosby, Tom ; Mansoor, Was ; Waters, Justin S. ; Neville-Webbe, Helen ; Darby, Suzanne ; Dent, Jo ; Seymour, Matthew ; Thompson, Joyce ; Sothi, Sharmila ; Blazeby, Jane ; Langley, Ruth E. ; Cunningham, David. / Safety and Efficacy of the Addition of Lapatinib to Perioperative Chemotherapy for Resectable HER2-Positive Gastroesophageal Adenocarcinoma : A Randomized Phase 2 Clinical Trial. In: JAMA Oncology. 2019 ; Vol. 5, No. 8. pp. 1181-1187.

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title = "Safety and Efficacy of the Addition of Lapatinib to Perioperative Chemotherapy for Resectable HER2-Positive Gastroesophageal Adenocarcinoma: A Randomized Phase 2 Clinical Trial",

keywords = "GASTRIC-CANCER, HER2, ESOPHAGEAL",

author = "Smyth, {Elizabeth C.} and Samuel Rowley and Cafferty, {Fay H.} and William Allum and Grabsch, {Heike I.} and Sally Stenning and Andrew Wotherspoon and Derek Alderson and Tom Crosby and Was Mansoor and Waters, {Justin S.} and Helen Neville-Webbe and Suzanne Darby and Jo Dent and Matthew Seymour and Joyce Thompson and Sharmila Sothi and Jane Blazeby and Langley, {Ruth E.} and David Cunningham",

year = "2019",

month = aug,

doi = "10.1001/jamaoncol.2019.1179",

language = "English",

volume = "5",

pages = "1181--1187",

journal = "JAMA Oncology",

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Smyth, EC, Rowley, S, Cafferty, FH, Allum, W, Grabsch, HI, Stenning, S, Wotherspoon, A, Alderson, D, Crosby, T, Mansoor, W, Waters, JS, Neville-Webbe, H, Darby, S, Dent, J, Seymour, M, Thompson, J, Sothi, S, Blazeby, J, Langley, RE & Cunningham, D 2019, 'Safety and Efficacy of the Addition of Lapatinib to Perioperative Chemotherapy for Resectable HER2-Positive Gastroesophageal Adenocarcinoma: A Randomized Phase 2 Clinical Trial', JAMA Oncology, vol. 5, no. 8, pp. 1181-1187. https://doi.org/10.1001/jamaoncol.2019.1179

Safety and Efficacy of the Addition of Lapatinib to Perioperative Chemotherapy for Resectable HER2-Positive Gastroesophageal Adenocarcinoma : A Randomized Phase 2 Clinical Trial. / Smyth, Elizabeth C.; Rowley, Samuel; Cafferty, Fay H.; Allum, William; Grabsch, Heike I.; Stenning, Sally; Wotherspoon, Andrew; Alderson, Derek; Crosby, Tom; Mansoor, Was; Waters, Justin S.; Neville-Webbe, Helen; Darby, Suzanne; Dent, Jo; Seymour, Matthew; Thompson, Joyce; Sothi, Sharmila; Blazeby, Jane; Langley, Ruth E.; Cunningham, David.

In: JAMA Oncology, Vol. 5, No. 8, 08.2019, p. 1181-1187.

Research output: Contribution to journal › Article › Academic › peer-review

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T2 - A Randomized Phase 2 Clinical Trial

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AU - Rowley, Samuel

AU - Cafferty, Fay H.

AU - Allum, William

AU - Grabsch, Heike I.

AU - Stenning, Sally

AU - Wotherspoon, Andrew

AU - Alderson, Derek

AU - Crosby, Tom

AU - Mansoor, Was

AU - Waters, Justin S.

AU - Neville-Webbe, Helen

AU - Darby, Suzanne

AU - Dent, Jo

AU - Seymour, Matthew

AU - Thompson, Joyce

AU - Sothi, Sharmila

AU - Blazeby, Jane

AU - Langley, Ruth E.

AU - Cunningham, David

PY - 2019/8

Y1 - 2019/8

KW - GASTRIC-CANCER

KW - HER2

KW - ESOPHAGEAL

U2 - 10.1001/jamaoncol.2019.1179

DO - 10.1001/jamaoncol.2019.1179

M3 - Article

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SP - 1181

EP - 1187

JO - JAMA Oncology

JF - JAMA Oncology

SN - 2374-2437

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ER -