Safety and efficacy of pharmacological inhibition of ketohexokinase in hereditary fructose intolerance

Evi Jc Koene; Amée M Buziau; David Cassiman; Timothy M Cox; Judith Bons; Jean L J M Scheijen; Casper G Schalkwijk; Steven Jr Meex; Aditi R Saxena; William P Esler; Vera B Schrauwen-Hinderling; Patrick Schrauwen; Martijn Cgj Brouwers

doi:10.1172/JCI187376

Safety and efficacy of pharmacological inhibition of ketohexokinase in hereditary fructose intolerance

Evi Jc Koene, Amée M Buziau, David Cassiman, Timothy M Cox, Judith Bons, Jean L J M Scheijen, Casper G Schalkwijk, Steven Jr Meex, Aditi R Saxena, William P Esler, Vera B Schrauwen-Hinderling, Patrick Schrauwen, Martijn Cgj Brouwers

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Article number	e187376
Journal	Journal of Clinical Investigation
Volume	135
Issue number	6
Early online date	11 Feb 2025
DOIs	https://doi.org/10.1172/JCI187376
Publication status	Published - 17 Mar 2025

Keywords

Carbohydrate metabolism
Clinical trials
Drug therapy
Endocrinology
Genetic diseases
Metabolism

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10.1172/JCI187376Licence: CC BY

Cite this

Koene, E. J., Buziau, A. M., Cassiman, D., Cox, T. M., Bons, J., Scheijen, J. L. J. M., Schalkwijk, C. G., Meex, S. J., Saxena, A. R., Esler, W. P., Schrauwen-Hinderling, V. B., Schrauwen, P., & Brouwers, M. C. (2025). Safety and efficacy of pharmacological inhibition of ketohexokinase in hereditary fructose intolerance. Journal of Clinical Investigation, 135(6), Article e187376. https://doi.org/10.1172/JCI187376

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Koene, EJ , Buziau, AM, Cassiman, D, Cox, TM, Bons, J , Scheijen, JLJM , Schalkwijk, CG , Meex, SJ, Saxena, AR, Esler, WP, Schrauwen-Hinderling, VB, Schrauwen, P & Brouwers, MC 2025, 'Safety and efficacy of pharmacological inhibition of ketohexokinase in hereditary fructose intolerance', Journal of Clinical Investigation, vol. 135, no. 6, e187376. https://doi.org/10.1172/JCI187376

TY - JOUR

T1 - Safety and efficacy of pharmacological inhibition of ketohexokinase in hereditary fructose intolerance

AU - Koene, Evi Jc

AU - Buziau, Amée M

AU - Cassiman, David

AU - Cox, Timothy M

AU - Bons, Judith

AU - Scheijen, Jean L J M

AU - Schalkwijk, Casper G

AU - Meex, Steven Jr

AU - Saxena, Aditi R

AU - Esler, William P

AU - Schrauwen-Hinderling, Vera B

AU - Schrauwen, Patrick

AU - Brouwers, Martijn Cgj

PY - 2025/3/17

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KW - Carbohydrate metabolism

KW - Clinical trials

KW - Drug therapy

KW - Endocrinology

KW - Genetic diseases

KW - Metabolism

U2 - 10.1172/JCI187376

DO - 10.1172/JCI187376

M3 - Article

SN - 0021-9738

VL - 135

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

IS - 6

M1 - e187376

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