S53P4 bioactive glass

D.J. Hulsen; N.A. van Gestel; J.A. Geurts; J.J. Arts

doi:10.1016/B978-0-08-100205-6.00004-5

S53P4 bioactive glass

D.J. Hulsen, N.A. van Gestel, J.A. Geurts, J.J. Arts

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic

Abstract

Bioactive glasses (BAGs) are synthetic bone graft substitutes that have been investigated by various orthopedic research groups in the past decades. These bone-bonding, osteoconductive materials can be used for various clinical applications. S53P4 is a specific composition of BAG, which is the main topic of this chapter, with the focus on granular S53P4. First, the working mechanism of S53P4 BAG is explained extensively on the basis of surface reactions, the bond to bone, osteostimulation, and bone proliferation around the material. S53P4 BAG has an antibacterial effect that is unique among bone graft materials, which makes the material useful in (suspected) septic bone defects. This antibacterial effect is discussed in detail. Additionally, its degradation and effect on angiogenesis are addressed. The chapter concludes with the current clinical applications of the material that are known in the literature.

Original language	English
Title of host publication	Management of Periprosthetic Joint Infections (PJIs)
Editors	J.J. Chris Arts, Jan Geurts
Publisher	Woodhead Publishing
Pages	69-80
Edition	1
ISBN (Electronic)	9780081002421
ISBN (Print)	9780081002056
DOIs	https://doi.org/10.1016/B978-0-08-100205-6.00004-5
Publication status	Published - 2016

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10.1016/B978-0-08-100205-6.00004-5

https://www.elsevier.com/books/management-of-periprosthetic-joint-infections-pjis/arts/978-0-08-100205-6

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title = "S53P4 bioactive glass",

abstract = "Bioactive glasses (BAGs) are synthetic bone graft substitutes that have been investigated by various orthopedic research groups in the past decades. These bone-bonding, osteoconductive materials can be used for various clinical applications. S53P4 is a specific composition of BAG, which is the main topic of this chapter, with the focus on granular S53P4. First, the working mechanism of S53P4 BAG is explained extensively on the basis of surface reactions, the bond to bone, osteostimulation, and bone proliferation around the material. S53P4 BAG has an antibacterial effect that is unique among bone graft materials, which makes the material useful in (suspected) septic bone defects. This antibacterial effect is discussed in detail. Additionally, its degradation and effect on angiogenesis are addressed. The chapter concludes with the current clinical applications of the material that are known in the literature.",

author = "D.J. Hulsen and {van Gestel}, N.A. and J.A. Geurts and J.J. Arts",

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language = "English",

isbn = "9780081002056",

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TY - CHAP

T1 - S53P4 bioactive glass

AU - Hulsen, D.J.

AU - van Gestel, N.A.

AU - Geurts, J.A.

AU - Arts, J.J.

PY - 2016

Y1 - 2016

N2 - Bioactive glasses (BAGs) are synthetic bone graft substitutes that have been investigated by various orthopedic research groups in the past decades. These bone-bonding, osteoconductive materials can be used for various clinical applications. S53P4 is a specific composition of BAG, which is the main topic of this chapter, with the focus on granular S53P4. First, the working mechanism of S53P4 BAG is explained extensively on the basis of surface reactions, the bond to bone, osteostimulation, and bone proliferation around the material. S53P4 BAG has an antibacterial effect that is unique among bone graft materials, which makes the material useful in (suspected) septic bone defects. This antibacterial effect is discussed in detail. Additionally, its degradation and effect on angiogenesis are addressed. The chapter concludes with the current clinical applications of the material that are known in the literature.

AB - Bioactive glasses (BAGs) are synthetic bone graft substitutes that have been investigated by various orthopedic research groups in the past decades. These bone-bonding, osteoconductive materials can be used for various clinical applications. S53P4 is a specific composition of BAG, which is the main topic of this chapter, with the focus on granular S53P4. First, the working mechanism of S53P4 BAG is explained extensively on the basis of surface reactions, the bond to bone, osteostimulation, and bone proliferation around the material. S53P4 BAG has an antibacterial effect that is unique among bone graft materials, which makes the material useful in (suspected) septic bone defects. This antibacterial effect is discussed in detail. Additionally, its degradation and effect on angiogenesis are addressed. The chapter concludes with the current clinical applications of the material that are known in the literature.

U2 - 10.1016/B978-0-08-100205-6.00004-5

DO - 10.1016/B978-0-08-100205-6.00004-5

M3 - Chapter

SN - 9780081002056

SP - 69

EP - 80

BT - Management of Periprosthetic Joint Infections (PJIs)

A2 - Arts, J.J. Chris

A2 - Geurts, Jan

PB - Woodhead Publishing

ER -

S53P4 bioactive glass

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