S100B Protein maternal and fetal bloodstreams gradient in healthy and small for gestational age pregnancies

Andrea Sannia, Luc J. I. Zimmermann, Antonio W. D. Gavilanes, Hans J. S. Vles, Laura D. Serpero, Rosanna Frulio, Fabrizio Michetti, Diego Gazzolo*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Web of Science)


Background: Brain S100B assessment in maternal blood has been proposed as a useful tool for early perinatal brain damage detection. Among potential confounding factors the possibility of a protein gradient between maternal and fetal bloodstreams under pathophysiological conditions is consistent. The present study investigates in healthy and small gestational age fetuses (SGA) whether S100B concentrations differ among fetal and maternal bloodstreams. Methods: We conducted a case-control study in 160 pregnancies (SGA: n = 80; healthy: n = 80), in which standard monitoring parameters were recorded. S100B was assessed in arterial cord and in maternal blood samples at birth. Eighty non pregnant women (NP), matched for age at sampling, served as controls (1 SGA vs. 1 healthy vs. 1 NP). Results: Fetal S100B in SGA and healthy groups was significantly higher (P0.05) were observed between groups. No differences (P>0.05) in fetal S100B have been found between the studied groups. Maternal S100B of SGA and healthy groups was significantly higher (P0.05) were observed between SGA and control groups. Conclusion: The present study shows that S100B is pregnancy-dependent with the presence of a protein's gradient between fetal and maternal bloodstreams. The present data suggests that non-invasive fetal brain monitoring is becoming possible in opening a new cue on further investigations on S100B fetal/maternal gradient changes under pathological conditions.
Original languageEnglish
Pages (from-to)1337-1340
JournalClinica Chimica Acta
Issue number15-16
Publication statusPublished - 15 Jul 2011


  • S100B protein
  • Small for gestational age
  • Prematurity
  • Pregnancy
  • Brain

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