S100B protein, cerebral ultrasound and magnetic resonance imaging patterns in brain injured preterm infants

G. Gasparroni; A. Graziosi; I. Bersani; M. Caulo; B. Moataza; H. Aboulgar; H. Mufeed; I. Iskander; M. Kornacka; D. Gruzfeld; A. Dotta; I. Savarese; N. Chukhlantseva; L.G. Tina; F. Nigro; G. Livolti; F. Galvano; C. Di Battista; E. D'Adamo; A.P. Primavera; G. Lapergola; M. Conte; R. Salomone; M. Perrotta; D. Panichi; G. Levantini; M. Catenaro; C. Strozzi; A. Maconi; G. Centini; F. Chiarelli; F. D'Antonio; D.A.W. Gavilanes; D. Gazzolo

doi:10.1515/cclm-2021-0278

S100B protein, cerebral ultrasound and magnetic resonance imaging patterns in brain injured preterm infants

G. Gasparroni, A. Graziosi, I. Bersani, M. Caulo, B. Moataza, H. Aboulgar, H. Mufeed, I. Iskander, M. Kornacka, D. Gruzfeld, A. Dotta, I. Savarese, N. Chukhlantseva, L.G. Tina, F. Nigro, G. Livolti, F. Galvano, C. Di Battista, E. D'Adamo, A.P. PrimaveraG. Lapergola, M. Conte, R. Salomone, M. Perrotta, D. Panichi, G. Levantini, M. Catenaro, C. Strozzi, A. Maconi, G. Centini, F. Chiarelli, F. D'Antonio, D.A.W. Gavilanes, D. Gazzolo^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objectives: The early detection of preterm infants (PI) at risk for intraventricular hemorrhage (IVH) and neurological sequelae still constitutes an unsolved issue. We aimed at validating the role of S100B protein in the early diagnosis and prognosis of IVH in PI by means of cerebral ultrasound (CUS) and magnetic resonance imaging (MRI) today considered standard of care procedures.Methods: We conducted an observational case-control study in 216 PI of whom 36 with IVH and 180 controls. Standard clinical, laboratory, radiological monitoring procedures and S100B urine measurement were performed at four time-points (first void, 24, 48, 96 h) after birth. Cerebral MRI was performed at 40-42 weeks of corrected gestational age.Results: Elevated (p<0.001, for all) S100B levels were observed in the IVH group at all monitoring time-point particularly at first void when standard monitoring procedures were still silent or unavailable. S100B measured at first void correlated (p<0.001) with the grade of hemorrhage by means of CUS and with the site and extension of neurological lesion (p<0.001, for all) as assessed by MRI.Conclusions: The present results showing a correlation among S100B and CUS and MRI offer additional support to the inclusion of the protein in clinical daily management of cases at risk for IVH and adverse neurological outcome. The findings open the way to further investigations in PI aimed at validating new neurobiomarkers by means of S100B.

Original language	English
Pages (from-to)	1527-1534
Number of pages	8
Journal	Clinical Chemistry and Laboratory Medicine
Volume	59
Issue number	9
DOIs	https://doi.org/10.1515/cclm-2021-0278
Publication status	Published - 1 Aug 2021

Keywords

cerebral ultrasound
intraventricular hemorrhage
magnetic resonance imaging
preterm infants
S100B
INTRAVENTRICULAR HEMORRHAGE
S100-BETA PROTEIN
GESTATIONAL-AGE
BIRTH
TERM

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10.1515/cclm-2021-0278

Cite this

Gasparroni, G., Graziosi, A., Bersani, I., Caulo, M., Moataza, B., Aboulgar, H., Mufeed, H., Iskander, I., Kornacka, M., Gruzfeld, D., Dotta, A., Savarese, I., Chukhlantseva, N., Tina, L. G., Nigro, F., Livolti, G., Galvano, F., Di Battista, C., D'Adamo, E., ... Gazzolo, D. (2021). S100B protein, cerebral ultrasound and magnetic resonance imaging patterns in brain injured preterm infants. Clinical Chemistry and Laboratory Medicine, 59(9), 1527-1534. https://doi.org/10.1515/cclm-2021-0278

@article{bb01058b662449dda9c4fb7b13f91047,

title = "S100B protein, cerebral ultrasound and magnetic resonance imaging patterns in brain injured preterm infants",

abstract = "Objectives: The early detection of preterm infants (PI) at risk for intraventricular hemorrhage (IVH) and neurological sequelae still constitutes an unsolved issue. We aimed at validating the role of S100B protein in the early diagnosis and prognosis of IVH in PI by means of cerebral ultrasound (CUS) and magnetic resonance imaging (MRI) today considered standard of care procedures.Methods: We conducted an observational case-control study in 216 PI of whom 36 with IVH and 180 controls. Standard clinical, laboratory, radiological monitoring procedures and S100B urine measurement were performed at four time-points (first void, 24, 48, 96 h) after birth. Cerebral MRI was performed at 40-42 weeks of corrected gestational age.Results: Elevated (p<0.001, for all) S100B levels were observed in the IVH group at all monitoring time-point particularly at first void when standard monitoring procedures were still silent or unavailable. S100B measured at first void correlated (p<0.001) with the grade of hemorrhage by means of CUS and with the site and extension of neurological lesion (p<0.001, for all) as assessed by MRI.Conclusions: The present results showing a correlation among S100B and CUS and MRI offer additional support to the inclusion of the protein in clinical daily management of cases at risk for IVH and adverse neurological outcome. The findings open the way to further investigations in PI aimed at validating new neurobiomarkers by means of S100B.",

keywords = "cerebral ultrasound, intraventricular hemorrhage, magnetic resonance imaging, preterm infants, S100B, INTRAVENTRICULAR HEMORRHAGE, S100-BETA PROTEIN, GESTATIONAL-AGE, BIRTH, TERM",

author = "G. Gasparroni and A. Graziosi and I. Bersani and M. Caulo and B. Moataza and H. Aboulgar and H. Mufeed and I. Iskander and M. Kornacka and D. Gruzfeld and A. Dotta and I. Savarese and N. Chukhlantseva and L.G. Tina and F. Nigro and G. Livolti and F. Galvano and {Di Battista}, C. and E. D'Adamo and A.P. Primavera and G. Lapergola and M. Conte and R. Salomone and M. Perrotta and D. Panichi and G. Levantini and M. Catenaro and C. Strozzi and A. Maconi and G. Centini and F. Chiarelli and F. D'Antonio and D.A.W. Gavilanes and D. Gazzolo",

year = "2021",

month = aug,

day = "1",

doi = "10.1515/cclm-2021-0278",

language = "English",

volume = "59",

pages = "1527--1534",

journal = "Clinical Chemistry and Laboratory Medicine",

issn = "1434-6621",

publisher = "Walter de Gruyter GmbH",

number = "9",

}

Gasparroni, G, Graziosi, A, Bersani, I, Caulo, M, Moataza, B, Aboulgar, H, Mufeed, H, Iskander, I, Kornacka, M, Gruzfeld, D, Dotta, A, Savarese, I, Chukhlantseva, N, Tina, LG, Nigro, F, Livolti, G, Galvano, F, Di Battista, C, D'Adamo, E, Primavera, AP, Lapergola, G, Conte, M, Salomone, R, Perrotta, M, Panichi, D, Levantini, G, Catenaro, M, Strozzi, C, Maconi, A, Centini, G, Chiarelli, F, D'Antonio, F, Gavilanes, DAW & Gazzolo, D 2021, 'S100B protein, cerebral ultrasound and magnetic resonance imaging patterns in brain injured preterm infants', Clinical Chemistry and Laboratory Medicine, vol. 59, no. 9, pp. 1527-1534. https://doi.org/10.1515/cclm-2021-0278

TY - JOUR

T1 - S100B protein, cerebral ultrasound and magnetic resonance imaging patterns in brain injured preterm infants

AU - Gasparroni, G.

AU - Graziosi, A.

AU - Bersani, I.

AU - Caulo, M.

AU - Moataza, B.

AU - Aboulgar, H.

AU - Mufeed, H.

AU - Iskander, I.

AU - Kornacka, M.

AU - Gruzfeld, D.

AU - Dotta, A.

AU - Savarese, I.

AU - Chukhlantseva, N.

AU - Tina, L.G.

AU - Nigro, F.

AU - Livolti, G.

AU - Galvano, F.

AU - Di Battista, C.

AU - D'Adamo, E.

AU - Primavera, A.P.

AU - Lapergola, G.

AU - Conte, M.

AU - Salomone, R.

AU - Perrotta, M.

AU - Panichi, D.

AU - Levantini, G.

AU - Catenaro, M.

AU - Strozzi, C.

AU - Maconi, A.

AU - Centini, G.

AU - Chiarelli, F.

AU - D'Antonio, F.

AU - Gavilanes, D.A.W.

AU - Gazzolo, D.

PY - 2021/8/1

Y1 - 2021/8/1

N2 - Objectives: The early detection of preterm infants (PI) at risk for intraventricular hemorrhage (IVH) and neurological sequelae still constitutes an unsolved issue. We aimed at validating the role of S100B protein in the early diagnosis and prognosis of IVH in PI by means of cerebral ultrasound (CUS) and magnetic resonance imaging (MRI) today considered standard of care procedures.Methods: We conducted an observational case-control study in 216 PI of whom 36 with IVH and 180 controls. Standard clinical, laboratory, radiological monitoring procedures and S100B urine measurement were performed at four time-points (first void, 24, 48, 96 h) after birth. Cerebral MRI was performed at 40-42 weeks of corrected gestational age.Results: Elevated (p<0.001, for all) S100B levels were observed in the IVH group at all monitoring time-point particularly at first void when standard monitoring procedures were still silent or unavailable. S100B measured at first void correlated (p<0.001) with the grade of hemorrhage by means of CUS and with the site and extension of neurological lesion (p<0.001, for all) as assessed by MRI.Conclusions: The present results showing a correlation among S100B and CUS and MRI offer additional support to the inclusion of the protein in clinical daily management of cases at risk for IVH and adverse neurological outcome. The findings open the way to further investigations in PI aimed at validating new neurobiomarkers by means of S100B.

AB - Objectives: The early detection of preterm infants (PI) at risk for intraventricular hemorrhage (IVH) and neurological sequelae still constitutes an unsolved issue. We aimed at validating the role of S100B protein in the early diagnosis and prognosis of IVH in PI by means of cerebral ultrasound (CUS) and magnetic resonance imaging (MRI) today considered standard of care procedures.Methods: We conducted an observational case-control study in 216 PI of whom 36 with IVH and 180 controls. Standard clinical, laboratory, radiological monitoring procedures and S100B urine measurement were performed at four time-points (first void, 24, 48, 96 h) after birth. Cerebral MRI was performed at 40-42 weeks of corrected gestational age.Results: Elevated (p<0.001, for all) S100B levels were observed in the IVH group at all monitoring time-point particularly at first void when standard monitoring procedures were still silent or unavailable. S100B measured at first void correlated (p<0.001) with the grade of hemorrhage by means of CUS and with the site and extension of neurological lesion (p<0.001, for all) as assessed by MRI.Conclusions: The present results showing a correlation among S100B and CUS and MRI offer additional support to the inclusion of the protein in clinical daily management of cases at risk for IVH and adverse neurological outcome. The findings open the way to further investigations in PI aimed at validating new neurobiomarkers by means of S100B.

KW - cerebral ultrasound

KW - intraventricular hemorrhage

KW - magnetic resonance imaging

KW - preterm infants

KW - S100B

KW - INTRAVENTRICULAR HEMORRHAGE

KW - S100-BETA PROTEIN

KW - GESTATIONAL-AGE

KW - BIRTH

KW - TERM

U2 - 10.1515/cclm-2021-0278

DO - 10.1515/cclm-2021-0278

M3 - Article

C2 - 34008376

SN - 1434-6621

VL - 59

SP - 1527

EP - 1534

JO - Clinical Chemistry and Laboratory Medicine

JF - Clinical Chemistry and Laboratory Medicine

IS - 9

ER -