S100B protein, cerebral ultrasound and magnetic resonance imaging patterns in brain injured preterm infants

G. Gasparroni, A. Graziosi, I. Bersani, M. Caulo, B. Moataza, H. Aboulgar, H. Mufeed, I. Iskander, M. Kornacka, D. Gruzfeld, A. Dotta, I. Savarese, N. Chukhlantseva, L.G. Tina, F. Nigro, G. Livolti, F. Galvano, C. Di Battista, E. D'Adamo, A.P. PrimaveraG. Lapergola, M. Conte, R. Salomone, M. Perrotta, D. Panichi, G. Levantini, M. Catenaro, C. Strozzi, A. Maconi, G. Centini, F. Chiarelli, F. D'Antonio, D.A.W. Gavilanes, D. Gazzolo*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Objectives: The early detection of preterm infants (PI) at risk for intraventricular hemorrhage (IVH) and neurological sequelae still constitutes an unsolved issue. We aimed at validating the role of S100B protein in the early diagnosis and prognosis of IVH in PI by means of cerebral ultrasound (CUS) and magnetic resonance imaging (MRI) today considered standard of care procedures.Methods: We conducted an observational case-control study in 216 PI of whom 36 with IVH and 180 controls. Standard clinical, laboratory, radiological monitoring procedures and S100B urine measurement were performed at four time-points (first void, 24, 48, 96 h) after birth. Cerebral MRI was performed at 40-42 weeks of corrected gestational age.Results: Elevated (p<0.001, for all) S100B levels were observed in the IVH group at all monitoring time-point particularly at first void when standard monitoring procedures were still silent or unavailable. S100B measured at first void correlated (p<0.001) with the grade of hemorrhage by means of CUS and with the site and extension of neurological lesion (p<0.001, for all) as assessed by MRI.Conclusions: The present results showing a correlation among S100B and CUS and MRI offer additional support to the inclusion of the protein in clinical daily management of cases at risk for IVH and adverse neurological outcome. The findings open the way to further investigations in PI aimed at validating new neurobiomarkers by means of S100B.
Original languageEnglish
Pages (from-to)1527-1534
Number of pages8
JournalClinical Chemistry and Laboratory Medicine
Issue number9
Publication statusPublished - 1 Aug 2021


  • cerebral ultrasound
  • intraventricular hemorrhage
  • magnetic resonance imaging
  • preterm infants
  • S100B
  • TERM

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