Rsk2 Knockout Affects Emotional Behavior in the IntelliCage

Matthias Fischer*, Victoria Cabello, Sandy Popp, Sven Krackow, Leif Hommers, Juergen Deckert, Klaus-Peter Lesch, Angelika G. Schmitt-Boehrer

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Web of Science)

Abstract

Ribosomal s6 kinase 2 is a growth factor activated serine/threonine kinase and member of the ERK signaling pathway. Mutations in the Rsk2 gene cause Coffin-Lowry syndrome, a rare syndromic form of intellectual disability. The Rsk2 KO mouse model was shown to have learning and memory defects. We focused on the investigation of the emotional behavioral phenotype of Rsk2 KO mice mainly in the IntelliCage. They exhibited an anti-depressive, sucrose reward seeking phenotype and showed reduced anxiety. Spontaneous activity was increased in some conventional tests. However, KO mice did not show defects in place learning, working memory and motor impulsivity. In addition, we found changes of the monoaminergic system in HPLC and qRT-PCR experiments. Taken together, RSK2 not only plays a role in cognitive processes but also in emotional and reward-related behaviors.

Original languageEnglish
Pages (from-to)434-448
Number of pages15
JournalBehavior Genetics
Volume47
Issue number4
DOIs
Publication statusPublished - Jul 2017

Keywords

  • Ribosomal S6 kinase 2
  • Rsk2
  • Coffin-Lowry syndrome
  • IntelliCage
  • Mouse
  • COFFIN-LOWRY-SYNDROME
  • COGNITIVE FUNCTION
  • PROTEIN-KINASES
  • MRSK2-KO MOUSE
  • GENE RSK2
  • MEMORY
  • DROSOPHILA
  • MODEL
  • EXPRESSION
  • STRESS

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