Role of weekday variation on glucose, insulin, and triglyceride: A cross-sectional analysis from The Maastricht Study

Kim Katrine Bjerring Clemmensen, Annemarie Koster, Johannes T H Nielen, Pieter C Dagnelie, Coen D A Stehouwer, Hans Bosma, Anke Wesselius, Kristine Færch, Simone J P M Eussen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


CONTEXT: The timing of sleep, physical activity and dietary intake shows variation over the week, with different timings in the weekend compared to the weekdays, which may potentially lead to impaired glucose and lipid regulation on Mondays compared to other weekdays.

OBJECTIVE: The aim of the study was to investigate differences in glucose metabolism and fasting triglyceride concentrations on Mondays compared to the rest of the week.

DESIGN, SETTING AND PARTICIPANTS: This cross-sectional study is based on data from The Maastricht Study, including 6067 participants without known diabetes and 1568 previously diagnosed with type 2 diabetes.

MAIN OUTCOME MEASURES: Confounder-adjusted linear regression analysis was applied to study the associations of day of the week of examination with glucose and insulin responses to an oral glucose tolerance test (OGTT) and fasting triglyceride concentrations.

RESULTS: In fully confounder-adjusted models, mean (95% CI) concentrations of fasting glucose, insulin, and triglycerides were slightly higher on Mondays compared with the other weekdays (glucose: 1% (0;2); insulin: 9% (1;18); triglycerides: 5% (2;8)). Interaction analyses revealed that the association of weekday with insulin was only pronounced in men (18% (3;35), but not in women (1% (-8;10)), whereas the associations with glucose and triglycerides were only apparent for individuals with known type 2 diabetes (glucose: 4% (0;7); triglycerides: 14% (6;23) compared to the background population (glucose: 0% (0;1); triglycerides: 3% (0;6)).

DISCUSSION: Being examined on a Monday was associated with higher fasting insulin concentrations among men but not women.

Original languageEnglish
Pages (from-to)E3145-E3151
Number of pages7
JournalJournal of Clinical Endocrinology & Metabolism
Issue number8
Early online date16 May 2022
Publication statusPublished - 14 Jul 2022


  • DIET
  • metabolism
  • oral glucose tolerance test
  • triglyceride
  • weekday

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