Role of Vitamin K-Dependent Factors Protein S and GAS6 and TAM Receptors in SARS-CoV-2 Infection and COVID-19-Associated Immunothrombosis

A. Tutusaus, M. Mari, J.T. Ortiz-Perez, G.A.F. Nicolaes, A. Morales*, P.G. de Frutos*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

The vitamin K-dependent factors protein S (PROS1) and growth-arrest-specific gene 6 (GAS6) and their tyrosine kinase receptors TYRO3, AXL, and MERTK, the TAM subfamily of receptor tyrosine kinases (RTK), are key regulators of inflammation and vascular response to damage. TAM signaling, which has largely studied in the immune system and in cancer, has been involved in coagulation-related pathologies. Because of these established biological functions, the GAS6-PROS1/TAM system is postulated to play an important role in SARS-CoV-2 infection and progression complications. The participation of the TAM system in vascular function and pathology has been previously reported. However, in the context of COVID-19, the role of TAMs could provide new clues in virus-host interplay with important consequences in the way that we understand this pathology. From the viral mimicry used by SARS-CoV-2 to infect cells, to the immunothrombosis that is associated with respiratory failure in COVID-19 patients, TAM signaling seems to be involved at different stages of the disease. TAM targeting is becoming an interesting biomedical strategy, which is useful for COVID-19 treatment now, but also for other viral and inflammatory diseases in the future.
Original languageEnglish
Article number2186
Number of pages15
JournalCells
Volume9
Issue number10
DOIs
Publication statusPublished - 1 Oct 2020

Keywords

  • activation
  • apoptotic cells
  • axl
  • coagulation
  • dendritic cells
  • endothelium
  • gas6
  • gene 6
  • growth
  • immune response
  • mer
  • mertk
  • negative regulator
  • tyro-3 family receptors
  • tyrosine kinase axl
  • viral infection
  • viral-infection
  • TYROSINE KINASE AXL
  • ACTIVATION
  • APOPTOTIC CELLS
  • GROWTH
  • DENDRITIC CELLS
  • TYRO-3 FAMILY RECEPTORS
  • MERTK
  • VIRAL-INFECTION
  • NEGATIVE REGULATOR
  • GENE 6
  • AXL
  • MER
  • GAS6

Fingerprint

Dive into the research topics of 'Role of Vitamin K-Dependent Factors Protein S and GAS6 and TAM Receptors in SARS-CoV-2 Infection and COVID-19-Associated Immunothrombosis'. Together they form a unique fingerprint.

Cite this