Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion

Amanda Santiago, Ligia Mendes Soares, Melissa Schepers, Humberto Milani, Tim Vanmierlo, Jos Prickaerts, Rubia M. de Oliveira

Research output: Contribution to journal › Article › Academic › peer-review

Original languageEnglish
Pages (from-to)360-370
Number of pages11
JournalNeuropharmacology
Volume138
DOIs
Publication statusPublished - 1 Aug 2018

Keywords

  • Phosphodiesterase inhibitor
  • Roflumilast
  • Chronic cerebral hypoperfusion
  • Memory
  • CAROTID-ARTERY MODEL
  • COGNITIVE IMPAIRMENT
  • INHIBITOR ROLIPRAM
  • MOUSE MODEL
  • PHOSPHODIESTERASE-4 INHIBITORS
  • ALZHEIMERS-DISEASE
  • HYPERTENSIVE-RATS
  • NEURONAL DAMAGE
  • INDUCED DEFECTS
  • PDE4 INHIBITOR

Cite this

Santiago, Amanda ; Soares, Ligia Mendes ; Schepers, Melissa ; Milani, Humberto ; Vanmierlo, Tim ; Prickaerts, Jos ; de Oliveira, Rubia M. / Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion. In: Neuropharmacology. 2018 ; Vol. 138. pp. 360-370.
@article{8dac943f18454660bbe1c3502df28ee1,
title = "Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion",
keywords = "Phosphodiesterase inhibitor, Roflumilast, Chronic cerebral hypoperfusion, Memory, CAROTID-ARTERY MODEL, COGNITIVE IMPAIRMENT, INHIBITOR ROLIPRAM, MOUSE MODEL, PHOSPHODIESTERASE-4 INHIBITORS, ALZHEIMERS-DISEASE, HYPERTENSIVE-RATS, NEURONAL DAMAGE, INDUCED DEFECTS, PDE4 INHIBITOR",
author = "Amanda Santiago and Soares, {Ligia Mendes} and Melissa Schepers and Humberto Milani and Tim Vanmierlo and Jos Prickaerts and {de Oliveira}, {Rubia M.}",
year = "2018",
month = "8",
day = "1",
doi = "10.1016/j.neuropharm.2018.06.019",
language = "English",
volume = "138",
pages = "360--370",
journal = "Neuropharmacology",
issn = "0028-3908",
publisher = "Elsevier Science",

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Santiago, A, Soares, LM, Schepers, M, Milani, H, Vanmierlo, T, Prickaerts, J & de Oliveira, RM 2018, 'Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion', Neuropharmacology, vol. 138, pp. 360-370. https://doi.org/10.1016/j.neuropharm.2018.06.019

Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion. / Santiago, Amanda; Soares, Ligia Mendes; Schepers, Melissa; Milani, Humberto; Vanmierlo, Tim; Prickaerts, Jos; de Oliveira, Rubia M.

In: Neuropharmacology, Vol. 138, 01.08.2018, p. 360-370.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion

AU - Santiago, Amanda

AU - Soares, Ligia Mendes

AU - Schepers, Melissa

AU - Milani, Humberto

AU - Vanmierlo, Tim

AU - Prickaerts, Jos

AU - de Oliveira, Rubia M.

PY - 2018/8/1

Y1 - 2018/8/1

KW - Phosphodiesterase inhibitor

KW - Roflumilast

KW - Chronic cerebral hypoperfusion

KW - Memory

KW - CAROTID-ARTERY MODEL

KW - COGNITIVE IMPAIRMENT

KW - INHIBITOR ROLIPRAM

KW - MOUSE MODEL

KW - PHOSPHODIESTERASE-4 INHIBITORS

KW - ALZHEIMERS-DISEASE

KW - HYPERTENSIVE-RATS

KW - NEURONAL DAMAGE

KW - INDUCED DEFECTS

KW - PDE4 INHIBITOR

U2 - 10.1016/j.neuropharm.2018.06.019

DO - 10.1016/j.neuropharm.2018.06.019

M3 - Article

VL - 138

SP - 360

EP - 370

JO - Neuropharmacology

JF - Neuropharmacology

SN - 0028-3908

ER -

Santiago A, Soares LM, Schepers M, Milani H, Vanmierlo T, Prickaerts J et al. Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion. Neuropharmacology. 2018 Aug 1;138:360-370. https://doi.org/10.1016/j.neuropharm.2018.06.019

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