Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion

Amanda Santiago; Ligia Mendes Soares; Melissa Schepers; Humberto Milani; Tim Vanmierlo; Jos Prickaerts; Rubia M. de Oliveira

doi:10.1016/j.neuropharm.2018.06.019

Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion

Amanda Santiago, Ligia Mendes Soares, Melissa Schepers, Humberto Milani, Tim Vanmierlo, Jos Prickaerts, Rubia M. de Oliveira^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

23 Citations (Web of Science)

9 Downloads (Pure)

Original language	English
Pages (from-to)	360-370
Number of pages	11
Journal	Neuropharmacology
Volume	138
DOIs	https://doi.org/10.1016/j.neuropharm.2018.06.019
Publication status	Published - 1 Aug 2018

Keywords

Phosphodiesterase inhibitor
Roflumilast
Chronic cerebral hypoperfusion
Memory
CAROTID-ARTERY MODEL
COGNITIVE IMPAIRMENT
INHIBITOR ROLIPRAM
MOUSE MODEL
PHOSPHODIESTERASE-4 INHIBITORS
ALZHEIMERS-DISEASE
HYPERTENSIVE-RATS
NEURONAL DAMAGE
INDUCED DEFECTS
PDE4 INHIBITOR

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10.1016/j.neuropharm.2018.06.019

Full TextFinal published version, 3.23 MBLicence: Taverne

Cite this

@article{8dac943f18454660bbe1c3502df28ee1,

title = "Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion",

keywords = "Phosphodiesterase inhibitor, Roflumilast, Chronic cerebral hypoperfusion, Memory, CAROTID-ARTERY MODEL, COGNITIVE IMPAIRMENT, INHIBITOR ROLIPRAM, MOUSE MODEL, PHOSPHODIESTERASE-4 INHIBITORS, ALZHEIMERS-DISEASE, HYPERTENSIVE-RATS, NEURONAL DAMAGE, INDUCED DEFECTS, PDE4 INHIBITOR",

author = "Amanda Santiago and Soares, {Ligia Mendes} and Melissa Schepers and Humberto Milani and Tim Vanmierlo and Jos Prickaerts and {de Oliveira}, {Rubia M.}",

year = "2018",

month = aug,

day = "1",

doi = "10.1016/j.neuropharm.2018.06.019",

language = "English",

volume = "138",

pages = "360--370",

journal = "Neuropharmacology",

issn = "0028-3908",

publisher = "Elsevier Science",

}

Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion. / Santiago, Amanda; Soares, Ligia Mendes; Schepers, Melissa; Milani, Humberto; Vanmierlo, Tim ; Prickaerts, Jos; de Oliveira, Rubia M.

In: Neuropharmacology, Vol. 138, 01.08.2018, p. 360-370.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion

AU - Santiago, Amanda

AU - Soares, Ligia Mendes

AU - Schepers, Melissa

AU - Milani, Humberto

AU - Vanmierlo, Tim

AU - Prickaerts, Jos

AU - de Oliveira, Rubia M.

PY - 2018/8/1

Y1 - 2018/8/1

KW - Phosphodiesterase inhibitor

KW - Roflumilast

KW - Chronic cerebral hypoperfusion

KW - Memory

KW - CAROTID-ARTERY MODEL

KW - COGNITIVE IMPAIRMENT

KW - INHIBITOR ROLIPRAM

KW - MOUSE MODEL

KW - PHOSPHODIESTERASE-4 INHIBITORS

KW - ALZHEIMERS-DISEASE

KW - HYPERTENSIVE-RATS

KW - NEURONAL DAMAGE

KW - INDUCED DEFECTS

KW - PDE4 INHIBITOR

U2 - 10.1016/j.neuropharm.2018.06.019

DO - 10.1016/j.neuropharm.2018.06.019

M3 - Article

C2 - 29933009

VL - 138

SP - 360

EP - 370

JO - Neuropharmacology

JF - Neuropharmacology

SN - 0028-3908

ER -