Risks of Opioids in ST-Elevation Myocardial Infarction: A Review

Anne Henrieke Tavenier; Renicus Suffridus Hermanides; Jan Paul Ottervanger; Peter Gerrit Johannes Ter Horst; Elvin Kedhi; Adriaan W. J. van't Hof

doi:10.1007/s40264-018-0710-y

Risks of Opioids in ST-Elevation Myocardial Infarction: A Review

Anne Henrieke Tavenier^*, Renicus Suffridus Hermanides, Jan Paul Ottervanger, Peter Gerrit Johannes Ter Horst, Elvin Kedhi, Adriaan W. J. van't Hof

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Although opioids are recommended and frequently used in the acute phase of ST-elevation myocardial infarction (STEMI), their use is accompanied by serious side effects. In particular, gastrointestinal adverse effects may disturb absorption of essential oral medication like platelet inhibitors. This may cause suboptimal platelet inhibition and increased risk of acute stent thrombosis. Some clinical studies have already demonstrated these negative results. Alternative strategies to optimize platelet inhibition and pain relief in STEMI are being investigated. Clinicians should become more aware of the potential side effects of opioids in STEMI.

Original language	English
Pages (from-to)	1303-1308
Number of pages	6
Journal	Drug Safety
Volume	41
Issue number	12
DOIs	https://doi.org/10.1007/s40264-018-0710-y
Publication status	Published - 1 Dec 2018

Keywords

PERCUTANEOUS CORONARY INTERVENTION
PLATELET INHIBITION
MORPHINE USE
SEGMENT ELEVATION
TABLETS
PAIN
ACETAMINOPHEN
REMIFENTANIL
AGGREGATION
ASSOCIATION

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title = "Risks of Opioids in ST-Elevation Myocardial Infarction: A Review",

abstract = "Although opioids are recommended and frequently used in the acute phase of ST-elevation myocardial infarction (STEMI), their use is accompanied by serious side effects. In particular, gastrointestinal adverse effects may disturb absorption of essential oral medication like platelet inhibitors. This may cause suboptimal platelet inhibition and increased risk of acute stent thrombosis. Some clinical studies have already demonstrated these negative results. Alternative strategies to optimize platelet inhibition and pain relief in STEMI are being investigated. Clinicians should become more aware of the potential side effects of opioids in STEMI.",

keywords = "PERCUTANEOUS CORONARY INTERVENTION, PLATELET INHIBITION, MORPHINE USE, SEGMENT ELEVATION, TABLETS, PAIN, ACETAMINOPHEN, REMIFENTANIL, AGGREGATION, ASSOCIATION",

author = "Tavenier, {Anne Henrieke} and Hermanides, {Renicus Suffridus} and Ottervanger, {Jan Paul} and {Ter Horst}, {Peter Gerrit Johannes} and Elvin Kedhi and {van't Hof}, {Adriaan W. J.}",

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month = dec,

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doi = "10.1007/s40264-018-0710-y",

language = "English",

volume = "41",

pages = "1303--1308",

journal = "Drug Safety",

issn = "0114-5916",

publisher = "Adis International Ltd",

number = "12",

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TY - JOUR

T1 - Risks of Opioids in ST-Elevation Myocardial Infarction

T2 - A Review

AU - Tavenier, Anne Henrieke

AU - Hermanides, Renicus Suffridus

AU - Ottervanger, Jan Paul

AU - Ter Horst, Peter Gerrit Johannes

AU - Kedhi, Elvin

AU - van't Hof, Adriaan W. J.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Although opioids are recommended and frequently used in the acute phase of ST-elevation myocardial infarction (STEMI), their use is accompanied by serious side effects. In particular, gastrointestinal adverse effects may disturb absorption of essential oral medication like platelet inhibitors. This may cause suboptimal platelet inhibition and increased risk of acute stent thrombosis. Some clinical studies have already demonstrated these negative results. Alternative strategies to optimize platelet inhibition and pain relief in STEMI are being investigated. Clinicians should become more aware of the potential side effects of opioids in STEMI.

AB - Although opioids are recommended and frequently used in the acute phase of ST-elevation myocardial infarction (STEMI), their use is accompanied by serious side effects. In particular, gastrointestinal adverse effects may disturb absorption of essential oral medication like platelet inhibitors. This may cause suboptimal platelet inhibition and increased risk of acute stent thrombosis. Some clinical studies have already demonstrated these negative results. Alternative strategies to optimize platelet inhibition and pain relief in STEMI are being investigated. Clinicians should become more aware of the potential side effects of opioids in STEMI.

KW - PERCUTANEOUS CORONARY INTERVENTION

KW - PLATELET INHIBITION

KW - MORPHINE USE

KW - SEGMENT ELEVATION

KW - TABLETS

KW - PAIN

KW - ACETAMINOPHEN

KW - REMIFENTANIL

KW - AGGREGATION

KW - ASSOCIATION

U2 - 10.1007/s40264-018-0710-y

DO - 10.1007/s40264-018-0710-y

M3 - (Systematic) Review article

SN - 0114-5916

VL - 41

SP - 1303

EP - 1308

JO - Drug Safety

JF - Drug Safety

IS - 12

ER -

Risks of Opioids in ST-Elevation Myocardial Infarction: A Review

Abstract

Keywords

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