Risk stratification with cervical length and fetal fibronectin in women with threatened preterm labor before 34weeks and not delivering within 7days

Frederik J. R. Hermans*, Merel M. C. Bruijn, Jolande Y. Vis, Femke F. Wilms, Martijn A. Oudijk, Martina M. Porath, Hubertina C. J. Scheepers, Kitty W. M. Bloemenkamp, Caroline J. Bax, Jerome M. J. Cornette, Bas W. A. Nij Bijvanck, Maureen T. M. Franssen, Frank P. H. A. Vandenbussche, Marjolein Kok, William A. Grobman, Joris A. M. Van Der Post, Patrick M. M. Bossuyt, Brent C. Opmeer, Ben Willem J. Mol, Ewoud SchuitGert-Jan Van Baaren

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Objective To stratify the risk of spontaneous preterm delivery using cervical length (CL) and fetal fibronectin (fFN) in women with threatened preterm labor who remained pregnant after 7days. DesignProspective observational study. SettingNationwide cohort of women with threatened preterm labor from the Netherlands. PopulationWomen with threatened preterm labor between 24 and 34weeks with a valid CL and fFN measurement and remaining pregnant 7days after admission. MethodsKaplan-Meier and Cox proportional hazards models were used to estimate cumulative percentages and hazard ratios (HR) for spontaneous delivery. Main outcome measuresSpontaneous delivery between 7 and 14days after initial presentation and spontaneous preterm delivery before 34weeks. ResultsThe risk of delivery between 7 and 14days was significantly increased for women with a CL
Original languageEnglish
Pages (from-to)715-721
JournalActa Obstetricia et Gynecologica Scandinavica
Issue number7
Publication statusPublished - Jul 2015


  • Threatened preterm labor
  • fetal fibronectin
  • cervical length
  • pregnancy complications
  • risk
  • prediction
  • spontaneous preterm delivery

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