Risk stratification with cervical length and fetal fibronectin in women with threatened preterm labor before 34weeks and not delivering within 7days

Frederik J. R. Hermans; Merel M. C. Bruijn; Jolande Y. Vis; Femke F. Wilms; Martijn A. Oudijk; Martina M. Porath; Hubertina C. J. Scheepers; Kitty W. M. Bloemenkamp; Caroline J. Bax; Jerome M. J. Cornette; Bas W. A. Nij Bijvanck; Maureen T. M. Franssen; Frank P. H. A. Vandenbussche; Marjolein Kok; William A. Grobman; Joris A. M. Van Der Post; Patrick M. M. Bossuyt; Brent C. Opmeer; Ben Willem J. Mol; Ewoud Schuit; Gert-Jan Van Baaren

doi:10.1111/aogs.12643

Risk stratification with cervical length and fetal fibronectin in women with threatened preterm labor before 34weeks and not delivering within 7days

Frederik J. R. Hermans^*, Merel M. C. Bruijn, Jolande Y. Vis, Femke F. Wilms, Martijn A. Oudijk, Martina M. Porath, Hubertina C. J. Scheepers, Kitty W. M. Bloemenkamp, Caroline J. Bax, Jerome M. J. Cornette, Bas W. A. Nij Bijvanck, Maureen T. M. Franssen, Frank P. H. A. Vandenbussche, Marjolein Kok, William A. Grobman, Joris A. M. Van Der Post, Patrick M. M. Bossuyt, Brent C. Opmeer, Ben Willem J. Mol, Ewoud SchuitGert-Jan Van Baaren

^*Corresponding author for this work

GROW - Reproductive and Perinatal Medicine

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objective To stratify the risk of spontaneous preterm delivery using cervical length (CL) and fetal fibronectin (fFN) in women with threatened preterm labor who remained pregnant after 7days. DesignProspective observational study. SettingNationwide cohort of women with threatened preterm labor from the Netherlands. PopulationWomen with threatened preterm labor between 24 and 34weeks with a valid CL and fFN measurement and remaining pregnant 7days after admission. MethodsKaplan-Meier and Cox proportional hazards models were used to estimate cumulative percentages and hazard ratios (HR) for spontaneous delivery. Main outcome measuresSpontaneous delivery between 7 and 14days after initial presentation and spontaneous preterm delivery before 34weeks. ResultsThe risk of delivery between 7 and 14days was significantly increased for women with a CL

Original language	English
Pages (from-to)	715-721
Journal	Acta Obstetricia et Gynecologica Scandinavica
Volume	94
Issue number	7
DOIs	https://doi.org/10.1111/aogs.12643
Publication status	Published - Jul 2015

Keywords

Threatened preterm labor
fetal fibronectin
cervical length
pregnancy complications
risk
prediction
spontaneous preterm delivery

Access to Document

10.1111/aogs.12643

Cite this

Hermans, F. J. R., Bruijn, M. M. C., Vis, J. Y., Wilms, F. F., Oudijk, M. A., Porath, M. M., Scheepers, H. C. J., Bloemenkamp, K. W. M., Bax, C. J., Cornette, J. M. J., Bijvanck, B. W. A. N., Franssen, M. T. M., Vandenbussche, F. P. H. A., Kok, M., Grobman, W. A., Van Der Post, J. A. M., Bossuyt, P. M. M., Opmeer, B. C., Mol, B. W. J., ... Van Baaren, G.-J. (2015). Risk stratification with cervical length and fetal fibronectin in women with threatened preterm labor before 34weeks and not delivering within 7days. Acta Obstetricia et Gynecologica Scandinavica, 94(7), 715-721. https://doi.org/10.1111/aogs.12643

@article{69869e318b7e4fe8b3d3c71a5c4cc351,

title = "Risk stratification with cervical length and fetal fibronectin in women with threatened preterm labor before 34weeks and not delivering within 7days",

abstract = "Objective To stratify the risk of spontaneous preterm delivery using cervical length (CL) and fetal fibronectin (fFN) in women with threatened preterm labor who remained pregnant after 7days. DesignProspective observational study. SettingNationwide cohort of women with threatened preterm labor from the Netherlands. PopulationWomen with threatened preterm labor between 24 and 34weeks with a valid CL and fFN measurement and remaining pregnant 7days after admission. MethodsKaplan-Meier and Cox proportional hazards models were used to estimate cumulative percentages and hazard ratios (HR) for spontaneous delivery. Main outcome measuresSpontaneous delivery between 7 and 14days after initial presentation and spontaneous preterm delivery before 34weeks. ResultsThe risk of delivery between 7 and 14days was significantly increased for women with a CL",

keywords = "Threatened preterm labor, fetal fibronectin, cervical length, pregnancy complications, risk, prediction, spontaneous preterm delivery",

author = "Hermans, {Frederik J. R.} and Bruijn, {Merel M. C.} and Vis, {Jolande Y.} and Wilms, {Femke F.} and Oudijk, {Martijn A.} and Porath, {Martina M.} and Scheepers, {Hubertina C. J.} and Bloemenkamp, {Kitty W. M.} and Bax, {Caroline J.} and Cornette, {Jerome M. J.} and Bijvanck, {Bas W. A. Nij} and Franssen, {Maureen T. M.} and Vandenbussche, {Frank P. H. A.} and Marjolein Kok and Grobman, {William A.} and {Van Der Post}, {Joris A. M.} and Bossuyt, {Patrick M. M.} and Opmeer, {Brent C.} and Mol, {Ben Willem J.} and Ewoud Schuit and {Van Baaren}, Gert-Jan",

year = "2015",

month = jul,

doi = "10.1111/aogs.12643",

language = "English",

volume = "94",

pages = "715--721",

journal = "Acta Obstetricia et Gynecologica Scandinavica",

issn = "0001-6349",

publisher = "Wiley",

number = "7",

}

Hermans, FJR, Bruijn, MMC, Vis, JY, Wilms, FF, Oudijk, MA, Porath, MM, Scheepers, HCJ, Bloemenkamp, KWM, Bax, CJ, Cornette, JMJ, Bijvanck, BWAN, Franssen, MTM, Vandenbussche, FPHA, Kok, M, Grobman, WA, Van Der Post, JAM, Bossuyt, PMM, Opmeer, BC, Mol, BWJ, Schuit, E & Van Baaren, G-J 2015, 'Risk stratification with cervical length and fetal fibronectin in women with threatened preterm labor before 34weeks and not delivering within 7days', Acta Obstetricia et Gynecologica Scandinavica, vol. 94, no. 7, pp. 715-721. https://doi.org/10.1111/aogs.12643

Risk stratification with cervical length and fetal fibronectin in women with threatened preterm labor before 34weeks and not delivering within 7days. / Hermans, Frederik J. R.; Bruijn, Merel M. C.; Vis, Jolande Y. et al.
In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 94, No. 7, 07.2015, p. 715-721.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Risk stratification with cervical length and fetal fibronectin in women with threatened preterm labor before 34weeks and not delivering within 7days

AU - Hermans, Frederik J. R.

AU - Bruijn, Merel M. C.

AU - Vis, Jolande Y.

AU - Wilms, Femke F.

AU - Oudijk, Martijn A.

AU - Porath, Martina M.

AU - Scheepers, Hubertina C. J.

AU - Bloemenkamp, Kitty W. M.

AU - Bax, Caroline J.

AU - Cornette, Jerome M. J.

AU - Bijvanck, Bas W. A. Nij

AU - Franssen, Maureen T. M.

AU - Vandenbussche, Frank P. H. A.

AU - Kok, Marjolein

AU - Grobman, William A.

AU - Van Der Post, Joris A. M.

AU - Bossuyt, Patrick M. M.

AU - Opmeer, Brent C.

AU - Mol, Ben Willem J.

AU - Schuit, Ewoud

AU - Van Baaren, Gert-Jan

PY - 2015/7

Y1 - 2015/7

N2 - Objective To stratify the risk of spontaneous preterm delivery using cervical length (CL) and fetal fibronectin (fFN) in women with threatened preterm labor who remained pregnant after 7days. DesignProspective observational study. SettingNationwide cohort of women with threatened preterm labor from the Netherlands. PopulationWomen with threatened preterm labor between 24 and 34weeks with a valid CL and fFN measurement and remaining pregnant 7days after admission. MethodsKaplan-Meier and Cox proportional hazards models were used to estimate cumulative percentages and hazard ratios (HR) for spontaneous delivery. Main outcome measuresSpontaneous delivery between 7 and 14days after initial presentation and spontaneous preterm delivery before 34weeks. ResultsThe risk of delivery between 7 and 14days was significantly increased for women with a CL

AB - Objective To stratify the risk of spontaneous preterm delivery using cervical length (CL) and fetal fibronectin (fFN) in women with threatened preterm labor who remained pregnant after 7days. DesignProspective observational study. SettingNationwide cohort of women with threatened preterm labor from the Netherlands. PopulationWomen with threatened preterm labor between 24 and 34weeks with a valid CL and fFN measurement and remaining pregnant 7days after admission. MethodsKaplan-Meier and Cox proportional hazards models were used to estimate cumulative percentages and hazard ratios (HR) for spontaneous delivery. Main outcome measuresSpontaneous delivery between 7 and 14days after initial presentation and spontaneous preterm delivery before 34weeks. ResultsThe risk of delivery between 7 and 14days was significantly increased for women with a CL

KW - Threatened preterm labor

KW - fetal fibronectin

KW - cervical length

KW - pregnancy complications

KW - risk

KW - prediction

KW - spontaneous preterm delivery

U2 - 10.1111/aogs.12643

DO - 10.1111/aogs.12643

M3 - Article

C2 - 25845495

SN - 0001-6349

VL - 94

SP - 715

EP - 721

JO - Acta Obstetricia et Gynecologica Scandinavica

JF - Acta Obstetricia et Gynecologica Scandinavica

IS - 7

ER -