RISK OF FRACTURE IN PATIENTS WITH CHARCOT-MARIE-TOOTH DISEASE

S. Pouwels; A. de Boer; H.G. Leufkens; W.E.J. Weber; C. Cooper; F. de Vries

doi:10.1002/mus.24240

RISK OF FRACTURE IN PATIENTS WITH CHARCOT-MARIE-TOOTH DISEASE

S. Pouwels
, A. de Boer
, H.G. Leufkens
, W.E.J. Weber
, C. Cooper
, F. de Vries^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Introduction: In this study we evaluated fracture risk in patients with Charcot-Marie-Tooth (CMT) disease. Methods: We conducted a retrospective cohort study using the UK Clinical Practice Research Datalink (1987-2012). Each patient with CMT disease was matched with up to 6 patients without a history of CMT disease. The outcome measure was fractures. Results: The risk of non-osteoporotic fracture was statistically significantly increased [adjusted hazard ratio (AHR) 1.47, 95% confidence interval (CI) 1.01-2.14], whereas risk of any and osteoporotic fracture did not reach statistical significance compared with control patients [AHR 1.31 (95% CI 0.98-1.74) and AHR 1.10 (95% CI 0.69-1.74), respectively]. Conclusions: CMT patients have a 1.5-fold increased risk for non-osteoporotic fracture. Studies with larger numbers of CMT patients and with additional data on CMT subtype, bone mineral density, and functional status should be performed to confirm a true association between CMT and an increased risk of fracture. Muscle Nerve50: 919-924, 2014

Original language	English
Pages (from-to)	919-924
Journal	Muscle & Nerve
Volume	50
Issue number	6
DOIs	https://doi.org/10.1002/mus.24240
Publication status	Published - 1 Jan 2014

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@article{5869ee81eb81443596c2bdee348c297b,

title = "RISK OF FRACTURE IN PATIENTS WITH CHARCOT-MARIE-TOOTH DISEASE",

abstract = "Introduction: In this study we evaluated fracture risk in patients with Charcot-Marie-Tooth (CMT) disease. Methods: We conducted a retrospective cohort study using the UK Clinical Practice Research Datalink (1987-2012). Each patient with CMT disease was matched with up to 6 patients without a history of CMT disease. The outcome measure was fractures. Results: The risk of non-osteoporotic fracture was statistically significantly increased [adjusted hazard ratio (AHR) 1.47, 95\% confidence interval (CI) 1.01-2.14], whereas risk of any and osteoporotic fracture did not reach statistical significance compared with control patients [AHR 1.31 (95\% CI 0.98-1.74) and AHR 1.10 (95\% CI 0.69-1.74), respectively]. Conclusions: CMT patients have a 1.5-fold increased risk for non-osteoporotic fracture. Studies with larger numbers of CMT patients and with additional data on CMT subtype, bone mineral density, and functional status should be performed to confirm a true association between CMT and an increased risk of fracture. Muscle Nerve50: 919-924, 2014",

author = "S. Pouwels and \{de Boer\}, A. and H.G. Leufkens and W.E.J. Weber and C. Cooper and \{de Vries\}, F.",

year = "2014",

month = jan,

day = "1",

doi = "10.1002/mus.24240",

language = "English",

volume = "50",

pages = "919--924",

journal = "Muscle \& Nerve",

issn = "0148-639X",

publisher = "John Wiley \& Sons Inc.",

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}

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T1 - RISK OF FRACTURE IN PATIENTS WITH CHARCOT-MARIE-TOOTH DISEASE

AU - Pouwels, S.

AU - de Boer, A.

AU - Leufkens, H.G.

AU - Weber, W.E.J.

AU - Cooper, C.

AU - de Vries, F.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Introduction: In this study we evaluated fracture risk in patients with Charcot-Marie-Tooth (CMT) disease. Methods: We conducted a retrospective cohort study using the UK Clinical Practice Research Datalink (1987-2012). Each patient with CMT disease was matched with up to 6 patients without a history of CMT disease. The outcome measure was fractures. Results: The risk of non-osteoporotic fracture was statistically significantly increased [adjusted hazard ratio (AHR) 1.47, 95% confidence interval (CI) 1.01-2.14], whereas risk of any and osteoporotic fracture did not reach statistical significance compared with control patients [AHR 1.31 (95% CI 0.98-1.74) and AHR 1.10 (95% CI 0.69-1.74), respectively]. Conclusions: CMT patients have a 1.5-fold increased risk for non-osteoporotic fracture. Studies with larger numbers of CMT patients and with additional data on CMT subtype, bone mineral density, and functional status should be performed to confirm a true association between CMT and an increased risk of fracture. Muscle Nerve50: 919-924, 2014

AB - Introduction: In this study we evaluated fracture risk in patients with Charcot-Marie-Tooth (CMT) disease. Methods: We conducted a retrospective cohort study using the UK Clinical Practice Research Datalink (1987-2012). Each patient with CMT disease was matched with up to 6 patients without a history of CMT disease. The outcome measure was fractures. Results: The risk of non-osteoporotic fracture was statistically significantly increased [adjusted hazard ratio (AHR) 1.47, 95% confidence interval (CI) 1.01-2.14], whereas risk of any and osteoporotic fracture did not reach statistical significance compared with control patients [AHR 1.31 (95% CI 0.98-1.74) and AHR 1.10 (95% CI 0.69-1.74), respectively]. Conclusions: CMT patients have a 1.5-fold increased risk for non-osteoporotic fracture. Studies with larger numbers of CMT patients and with additional data on CMT subtype, bone mineral density, and functional status should be performed to confirm a true association between CMT and an increased risk of fracture. Muscle Nerve50: 919-924, 2014

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DO - 10.1002/mus.24240

M3 - Article

C2 - 24634316

SN - 0148-639X

VL - 50

SP - 919

EP - 924

JO - Muscle & Nerve

JF - Muscle & Nerve

IS - 6

ER -

RISK OF FRACTURE IN PATIENTS WITH CHARCOT-MARIE-TOOTH DISEASE

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