RISK OF FRACTURE IN PATIENTS WITH CHARCOT-MARIE-TOOTH DISEASE

S. Pouwels, A. de Boer, H.G. Leufkens, W.E.J. Weber, C. Cooper, F. de Vries

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Introduction: In this study we evaluated fracture risk in patients with Charcot-Marie-Tooth (CMT) disease. Methods: We conducted a retrospective cohort study using the UK Clinical Practice Research Datalink (1987-2012). Each patient with CMT disease was matched with up to 6 patients without a history of CMT disease. The outcome measure was fractures. Results: The risk of non-osteoporotic fracture was statistically significantly increased [adjusted hazard ratio (AHR) 1.47, 95% confidence interval (CI) 1.01-2.14], whereas risk of any and osteoporotic fracture did not reach statistical significance compared with control patients [AHR 1.31 (95% CI 0.98-1.74) and AHR 1.10 (95% CI 0.69-1.74), respectively]. Conclusions: CMT patients have a 1.5-fold increased risk for non-osteoporotic fracture. Studies with larger numbers of CMT patients and with additional data on CMT subtype, bone mineral density, and functional status should be performed to confirm a true association between CMT and an increased risk of fracture. Muscle Nerve50: 919-924, 2014
Original languageEnglish
Pages (from-to)919-924
JournalMuscle & Nerve
Volume50
Issue number6
DOIs
Publication statusPublished - 1 Jan 2014

Cite this