TY - JOUR
T1 - Risk of Colon Cancer and Coffee, Tea, and Sugar-Sweetened Soft Drink Intake: Pooled Analysis of Prospective Cohort Studies
AU - Zhang, Xuehong
AU - Albanes, Demetrius
AU - Beeson, W. Lawrence
AU - van den Brandt, Piet A.
AU - Buring, Julie E.
AU - Flood, Andrew
AU - Freudenheim, Jo L.
AU - Giovannucci, Edward L.
AU - Goldbohm, R. Alexandra (Sandra)
AU - Jaceldo-Siegl, Karen
AU - Jacobs, Eric J.
AU - Krogh, Vittorio
AU - Larsson, Susanna C.
AU - Marshall, James R.
AU - McCullough, Marjorie L.
AU - Miller, Anthony B.
AU - Robien, Kim
AU - Rohan, Thomas E.
AU - Schatzkin, Arthur
AU - Sieri, Sabina
AU - Spiegelman, Donna
AU - Virtamo, Jarmo
AU - Wolk, Alicja
AU - Willett, Walter C.
AU - Zhang, Shumin M.
AU - Smith-Warner, Stephanie A.
PY - 2010/6/2
Y1 - 2010/6/2
N2 - The relationships between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk remain unresolved. We investigated prospectively the association between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk in a pooled analysis of primary data from 13 cohort studies. Among 731 441 participants followed for up to 6-20 years, 5604 incident colon cancer case patients were identified. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models and then pooled using a random-effects model. All statistical tests were two-sided. Compared with nonconsumers, the pooled multivariable relative risks were 1.07 (95% CI = 0.89 to 1.30, P-trend = .68) for coffee consumption greater than 1400 g/d (about six 8-oz cups) and 1.28 (95% CI = 1.02 to 1.61, P-trend = .01) for tea consumption greater than 900 g/d (about four 8-oz cups). For sugar-sweetened carbonated soft drink consumption, the pooled multivariable relative risk comparing consumption greater than 550 g/d (about 18 oz) to nonconsumers was 0.94 (95% CI = 0.66 to 1.32, P-trend = .91). No statistically significant between-studies heterogeneity was observed for the highest category of each beverage consumed (P > .20). The observed associations did not differ by sex, smoking status, alcohol consumption, body mass index, physical activity, or tumor site (P > .05). Drinking coffee or sugar-sweetened carbonated soft drinks was not associated with colon cancer risk. However, a modest positive association with higher tea consumption is possible and requires further study.
AB - The relationships between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk remain unresolved. We investigated prospectively the association between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk in a pooled analysis of primary data from 13 cohort studies. Among 731 441 participants followed for up to 6-20 years, 5604 incident colon cancer case patients were identified. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models and then pooled using a random-effects model. All statistical tests were two-sided. Compared with nonconsumers, the pooled multivariable relative risks were 1.07 (95% CI = 0.89 to 1.30, P-trend = .68) for coffee consumption greater than 1400 g/d (about six 8-oz cups) and 1.28 (95% CI = 1.02 to 1.61, P-trend = .01) for tea consumption greater than 900 g/d (about four 8-oz cups). For sugar-sweetened carbonated soft drink consumption, the pooled multivariable relative risk comparing consumption greater than 550 g/d (about 18 oz) to nonconsumers was 0.94 (95% CI = 0.66 to 1.32, P-trend = .91). No statistically significant between-studies heterogeneity was observed for the highest category of each beverage consumed (P > .20). The observed associations did not differ by sex, smoking status, alcohol consumption, body mass index, physical activity, or tumor site (P > .05). Drinking coffee or sugar-sweetened carbonated soft drinks was not associated with colon cancer risk. However, a modest positive association with higher tea consumption is possible and requires further study.
U2 - 10.1093/jnci/djq107
DO - 10.1093/jnci/djq107
M3 - Article
C2 - 20453203
SN - 0027-8874
VL - 102
SP - 771
EP - 783
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 11
ER -