Risk of adverse pregnancy outcomes in women with periodontal disease and the effectiveness of interventions in decreasing this risk: protocol for systematic overview of systematic reviews

Sizzle Vanterpool, Kathleen Tomsin, Leticia Reyes, Luc Zimmermann, Boris Kramer, Jasper Been*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Background: Periodontal disease is an inflammatory disease of the tissues supporting the teeth. Women who have periodontal disease while pregnant may be at risk of adverse pregnancy outcomes. Although the association between periodontal disease and adverse pregnancy outcomes has been addressed in a considerable number of systematic reviews and meta-analyses, there are important differences in the conclusions of these reviews. Systematic reviews assessing the effectivity of various therapeutic interventions to treat periodontal disease during pregnancy to try and reduce adverse pregnancy outcomes have also arrived at different conclusions. We aim to provide a systematic overview of systematic reviews comparing the frequency of adverse pregnancy outcomes between women with and without periodontal disease and/or evaluating the effect of preventive and therapeutic interventions for periodontal disease before or during pregnancy on adverse pregnancy outcomes.

Methods: We will include systematic reviews reporting on studies comparing adverse pregnancy outcomes: (i) between women with or without periodontal disease before (

Original languageEnglish
Article number16
Number of pages6
JournalSystematic Reviews
Publication statusPublished - 2016


  • Periodontal disease
  • Periodontitis
  • Pregnancy
  • Adverse pregnancy outcome
  • Preterm birth
  • Perinatal mortality
  • Maternal mortality
  • Treatment
  • Systematic review
  • Overview

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