Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology

Thomas M. Gorter; Dirk J. van Veldhuisen; Johann Bauersachs; Barry A. Borlaug; Jelena Celutkiene; Andrew J. S. Coats; Marisa G. Crespo-Leiro; Marco Guazzi; Veli-Pekka Harjola; Stephane Heymans; Loreena Hill; Mitja Lainscak; Carolyn S. P. Lam; Lars H. Lund; Alexander R. Lyon; Alexandre Mebazaa; Christian Mueller; Walter J. Paulus; Burkert Pieske; Massimo F. Piepoli; Frank Ruschitzka; Frans H. Rutten; Petar M. Seferovic; Scott D. Solomon; Sanjiv J. Shah; Filippos Triposkiadis; Rolf Wachter; Carsten Tschope; Rudolf A. de Boer

doi:10.1002/ejhf.1029

Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology

Thomas M. Gorter, Dirk J. van Veldhuisen, Johann Bauersachs, Barry A. Borlaug, Jelena Celutkiene, Andrew J. S. Coats, Marisa G. Crespo-Leiro, Marco Guazzi, Veli-Pekka Harjola, Stephane Heymans, Loreena Hill, Mitja Lainscak, Carolyn S. P. Lam, Lars H. Lund, Alexander R. Lyon, Alexandre Mebazaa, Christian Mueller, Walter J. Paulus, Burkert Pieske, Massimo F. PiepoliFrank Ruschitzka, Frans H. Rutten, Petar M. Seferovic, Scott D. Solomon, Sanjiv J. Shah, Filippos Triposkiadis, Rolf Wachter, Carsten Tschope, Rudolf A. de Boer^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

There is an unmet need for effective treatment strategies to reduce morbidity and mortality in patients with heart failure with preserved ejection fraction (HFpEF). Until recently, attention in patients with HFpEF was almost exclusively focused on the left side. However, it is now increasingly recognized that right heart dysfunction is common and contributes importantly to poor prognosis in HFpEF. More insights into the development of right heart dysfunction in HFpEF may aid to our knowledge about this complex disease and may eventually lead to better treatments to improve outcomes in these patients. In this position paper from the Heart Failure Association of the European Society of Cardiology, the Committee on Heart Failure with Preserved Ejection Fraction reviews the prevalence, diagnosis, and pathophysiology of right heart dysfunction and failure in patients with HFpEF. Finally, potential treatment strategies, important knowledge gaps and future directions regarding the right side in HFpEF are discussed.

Original language	English
Pages (from-to)	16-37
Number of pages	22
Journal	European journal of heart failure
Volume	20
Issue number	1
DOIs	https://doi.org/10.1002/ejhf.1029
Publication status	Published - 1 Jan 2018

Keywords

Heart failure
Right ventricular function
Pulmonary hypertension
Biomarkers
Heart failure with preserved ejection fraction
RIGHT-VENTRICULAR FUNCTION
PULMONARY ARTERIAL-HYPERTENSION
RANDOMIZED CONTROLLED-TRIAL
CARDIAC MAGNETIC-RESONANCE
CHRONIC KIDNEY-DISEASE
EXERCISE CAPACITY
ATRIAL-FIBRILLATION
PHOSPHODIESTERASE-5 INHIBITION
DIASTOLIC DYSFUNCTION
INVASIVE HEMODYNAMICS

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Gorter, T. M., van Veldhuisen, D. J., Bauersachs, J., Borlaug, B. A., Celutkiene, J., Coats, A. J. S., Crespo-Leiro, M. G., Guazzi, M., Harjola, V.-P., Heymans, S., Hill, L., Lainscak, M., Lam, C. S. P., Lund, L. H., Lyon, A. R., Mebazaa, A., Mueller, C., Paulus, W. J., Pieske, B., ... de Boer, R. A. (2018). Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology. European journal of heart failure, 20(1), 16-37. https://doi.org/10.1002/ejhf.1029

@article{514b5a16583b41a89313ebb4587bfbcf,

title = "Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology",

abstract = "There is an unmet need for effective treatment strategies to reduce morbidity and mortality in patients with heart failure with preserved ejection fraction (HFpEF). Until recently, attention in patients with HFpEF was almost exclusively focused on the left side. However, it is now increasingly recognized that right heart dysfunction is common and contributes importantly to poor prognosis in HFpEF. More insights into the development of right heart dysfunction in HFpEF may aid to our knowledge about this complex disease and may eventually lead to better treatments to improve outcomes in these patients. In this position paper from the Heart Failure Association of the European Society of Cardiology, the Committee on Heart Failure with Preserved Ejection Fraction reviews the prevalence, diagnosis, and pathophysiology of right heart dysfunction and failure in patients with HFpEF. Finally, potential treatment strategies, important knowledge gaps and future directions regarding the right side in HFpEF are discussed.",

keywords = "Heart failure, Right ventricular function, Pulmonary hypertension, Biomarkers, Heart failure with preserved ejection fraction, RIGHT-VENTRICULAR FUNCTION, PULMONARY ARTERIAL-HYPERTENSION, RANDOMIZED CONTROLLED-TRIAL, CARDIAC MAGNETIC-RESONANCE, CHRONIC KIDNEY-DISEASE, EXERCISE CAPACITY, ATRIAL-FIBRILLATION, PHOSPHODIESTERASE-5 INHIBITION, DIASTOLIC DYSFUNCTION, INVASIVE HEMODYNAMICS",

author = "Gorter, {Thomas M.} and {van Veldhuisen}, {Dirk J.} and Johann Bauersachs and Borlaug, {Barry A.} and Jelena Celutkiene and Coats, {Andrew J. S.} and Crespo-Leiro, {Marisa G.} and Marco Guazzi and Veli-Pekka Harjola and Stephane Heymans and Loreena Hill and Mitja Lainscak and Lam, {Carolyn S. P.} and Lund, {Lars H.} and Lyon, {Alexander R.} and Alexandre Mebazaa and Christian Mueller and Paulus, {Walter J.} and Burkert Pieske and Piepoli, {Massimo F.} and Frank Ruschitzka and Rutten, {Frans H.} and Seferovic, {Petar M.} and Solomon, {Scott D.} and Shah, {Sanjiv J.} and Filippos Triposkiadis and Rolf Wachter and Carsten Tschope and {de Boer}, {Rudolf A.}",

year = "2018",

month = jan,

day = "1",

doi = "10.1002/ejhf.1029",

language = "English",

volume = "20",

pages = "16--37",

journal = "European journal of heart failure",

issn = "1388-9842",

publisher = "John Wiley & Sons Inc.",

number = "1",

}

Gorter, TM, van Veldhuisen, DJ, Bauersachs, J, Borlaug, BA, Celutkiene, J, Coats, AJS, Crespo-Leiro, MG, Guazzi, M, Harjola, V-P, Heymans, S, Hill, L, Lainscak, M, Lam, CSP, Lund, LH, Lyon, AR, Mebazaa, A, Mueller, C, Paulus, WJ, Pieske, B, Piepoli, MF, Ruschitzka, F, Rutten, FH, Seferovic, PM, Solomon, SD, Shah, SJ, Triposkiadis, F, Wachter, R, Tschope, C & de Boer, RA 2018, 'Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology', European journal of heart failure, vol. 20, no. 1, pp. 16-37. https://doi.org/10.1002/ejhf.1029

Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology. / Gorter, Thomas M.; van Veldhuisen, Dirk J.; Bauersachs, Johann et al.
In: European journal of heart failure, Vol. 20, No. 1, 01.01.2018, p. 16-37.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology

AU - Gorter, Thomas M.

AU - van Veldhuisen, Dirk J.

AU - Bauersachs, Johann

AU - Borlaug, Barry A.

AU - Celutkiene, Jelena

AU - Coats, Andrew J. S.

AU - Crespo-Leiro, Marisa G.

AU - Guazzi, Marco

AU - Harjola, Veli-Pekka

AU - Heymans, Stephane

AU - Hill, Loreena

AU - Lainscak, Mitja

AU - Lam, Carolyn S. P.

AU - Lund, Lars H.

AU - Lyon, Alexander R.

AU - Mebazaa, Alexandre

AU - Mueller, Christian

AU - Paulus, Walter J.

AU - Pieske, Burkert

AU - Piepoli, Massimo F.

AU - Ruschitzka, Frank

AU - Rutten, Frans H.

AU - Seferovic, Petar M.

AU - Solomon, Scott D.

AU - Shah, Sanjiv J.

AU - Triposkiadis, Filippos

AU - Wachter, Rolf

AU - Tschope, Carsten

AU - de Boer, Rudolf A.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - There is an unmet need for effective treatment strategies to reduce morbidity and mortality in patients with heart failure with preserved ejection fraction (HFpEF). Until recently, attention in patients with HFpEF was almost exclusively focused on the left side. However, it is now increasingly recognized that right heart dysfunction is common and contributes importantly to poor prognosis in HFpEF. More insights into the development of right heart dysfunction in HFpEF may aid to our knowledge about this complex disease and may eventually lead to better treatments to improve outcomes in these patients. In this position paper from the Heart Failure Association of the European Society of Cardiology, the Committee on Heart Failure with Preserved Ejection Fraction reviews the prevalence, diagnosis, and pathophysiology of right heart dysfunction and failure in patients with HFpEF. Finally, potential treatment strategies, important knowledge gaps and future directions regarding the right side in HFpEF are discussed.

AB - There is an unmet need for effective treatment strategies to reduce morbidity and mortality in patients with heart failure with preserved ejection fraction (HFpEF). Until recently, attention in patients with HFpEF was almost exclusively focused on the left side. However, it is now increasingly recognized that right heart dysfunction is common and contributes importantly to poor prognosis in HFpEF. More insights into the development of right heart dysfunction in HFpEF may aid to our knowledge about this complex disease and may eventually lead to better treatments to improve outcomes in these patients. In this position paper from the Heart Failure Association of the European Society of Cardiology, the Committee on Heart Failure with Preserved Ejection Fraction reviews the prevalence, diagnosis, and pathophysiology of right heart dysfunction and failure in patients with HFpEF. Finally, potential treatment strategies, important knowledge gaps and future directions regarding the right side in HFpEF are discussed.

KW - Heart failure

KW - Right ventricular function

KW - Pulmonary hypertension

KW - Biomarkers

KW - Heart failure with preserved ejection fraction

KW - RIGHT-VENTRICULAR FUNCTION

KW - PULMONARY ARTERIAL-HYPERTENSION

KW - RANDOMIZED CONTROLLED-TRIAL

KW - CARDIAC MAGNETIC-RESONANCE

KW - CHRONIC KIDNEY-DISEASE

KW - EXERCISE CAPACITY

KW - ATRIAL-FIBRILLATION

KW - PHOSPHODIESTERASE-5 INHIBITION

KW - DIASTOLIC DYSFUNCTION

KW - INVASIVE HEMODYNAMICS

U2 - 10.1002/ejhf.1029

DO - 10.1002/ejhf.1029

M3 - Article

SN - 1388-9842

VL - 20

SP - 16

EP - 37

JO - European journal of heart failure

JF - European journal of heart failure

IS - 1

ER -

Gorter TM, van Veldhuisen DJ, Bauersachs J, Borlaug BA, Celutkiene J, Coats AJS et al. Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology. European journal of heart failure. 2018 Jan 1;20(1):16-37. doi: 10.1002/ejhf.1029